Results 111 to 120 of about 15,347 (200)

Investigation Binding Patterns of Human Carboxylesterase I (hCES I) with Broad Substrates by MD Simulations

, 2013
Human carboxylesterase I (hCES 1) plays an important role in the metabolism and activation of prodrugs, such as, the hydrolysis of a variety of drugs of prodrugs featuring an ester, amide or carbamate function. The bindings of the substrates of different
Shen, Hujun, Min, Hanyi, 李国辉, Zhang, Mingbo, Hanyi Min, Chu, Huiying, Li, Guohui   +6 more
core  

An in vitro evaluation of kratom (Mitragyna speciosa) on the catalytic activity of carboxylesterase 1 (CES1). [PDF]

Chem Biol Interact, 2023
Melchert PW, Zhang Q, Mukhopadhyay S, Kanumuri SRR, McCurdy CR, Markowitz JS.   +5 more
europepmc   +1 more source

Asymmetric Construction of a Multi-Pharmacophore-Containing Dispirotriheterocyclic Scaffold and Identification of a Human Carboxylesterase 1 Inhibitor

, 2018
A catalytic asymmetric [3 + 2] cyclization of novel 4-isothiocyanato pyrazolones and isatin-derived ketimines was developed, delivering a wide range of intriguing dispirotriheterocyclic products in high yield with excellent diastereoselectivity and ...
Shiqiang Wei (1477456), Xiaoze Bao (1490524), Xingkai Qian (5249099), Jingping Qu (556366), Baomin Wang (174006), Liwei Zou (1944679), Guangbo Ge (5249102)   +6 more
core   +1 more source

Insights into human carboxylesterase 2 stability and activity in vivo and in vitro [PDF]

, 2012
Dissertation to obtain a Master Degree in BiotechnologyDue to its role in ester containing xenobiotics metabolization, such as the activation of pro-drugs, carboxylesterase 2 (CES2) has become an attractive enzyme, with potential applications in the ...
Ferreira, Pedro Garcia
core  

Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity [PDF]

, 2020
The Wnt family of proteins are secreted signaling proteins that play key roles in regulating cellular functions. Recently, carboxylesterase Notum was shown to act as a negative regulator of Wnt signaling by mediating the removal of an essential ...
Patel, M, Woodward, HL, Frew, S, Jones, EY, Flint, A, Hillier, J, Mahy, W, Bictash, M, Steadman, D, Ruza, RR, Atkinson, BN, Willis, NJ, Vecchia, L, Papatheodorou, D, Monaghan, A, Walter, MW, Costa, A, Fish, PV, Zhao, Y, Svensson, F   +19 more
core  

Cloning, recombinant expression, and characterization of a Rhipicephalus microplus carboxylesterase. [version 1; peer review: 2 approved, 1 not approved]

Gates Open Research
Background The Rhipicephalus microplus carboxylesterase (CBE) is involved in synthetic pyrethroid (SP) hydrolysis and historic evidence suggests that a non-synonymous mutation (Asp374Asn) in CBE is associated with increased resistance towards SP-based ...
Michel Labuschagne
doaj   +1 more source

IL-33 Downregulates Hepatic Carboxylesterase 1 in Acute Liver Injury via Macrophage-derived Exosomal miR-27b-3p. [PDF]

J Clin Transl Hepatol, 2023
Gao P, Li M, Lu J, Xiang D, Wang X, Xu Y, Zu Y, Guan X, Li G, Zhang C.   +9 more
europepmc   +1 more source

In silico analysis of selected nutrition rich fruit of Bunch berry (Lantana camara) constituents as human acetylcholinesterase (hAchE), carbonic anhydrase II (hCA-II) and carboxylesterase 1 (hCES-1) inhibitory agents. [PDF]

Saudi J Biol Sci, 2023
Surya Prakash V, Radhakrishnan N, Vasantha-Srinivasan P, Veeramani C, El Newehy AS, Alsaif MA, Al-Numair KS.   +6 more
europepmc   +1 more source

Inhibition of chicken liver carboxylesterase by activated carbonyls and carbonyl hydrates

, 1996
Identical Kcat values (approximately 40 s-1) are obtained for the chicken liver carboxylesterase catalyzed hydrolysis of phenyl, p-nitrophenyl and o-nitrophenyl benzoates providing support for the involvement of an acyl-enzyme pathway, with the rate ...
King G.J., Bowles M.R., Zerner B., Berndt M.C.   +3 more
core   +1 more source

Carboxylesterase-1 Assisted Targeting of HDAC Inhibitors to Mononuclear Myeloid Cells in Inflammatory Bowel Disease. [PDF]

J Crohns Colitis, 2022
Elfiky AMI, Ghiboub M, Li Yim AYF, Hageman IL, Verhoeff J, de Krijger M, van Hamersveld PHP, Welting O, Admiraal I, Rahman S, Garcia-Vallejo JJ, Wildenberg ME, Tomlinson L, Gregory R, Rioja I, Prinjha RK, Furze RC, Lewis HD, Mander PK, Heinsbroek SEM, Bell MJ, de Jonge WJ.   +21 more
europepmc   +1 more source