Results 161 to 170 of about 22,222 (249)

Crystal Structures of Human Carboxylesterase 1 in Covalent Complexes with the Chemical Warfare Agents Soman and Tabun † , ‡

, 2021
Carol Edwards, Douglas M. Cerasoli, Donald M. Maxwell, Christopher Fleming, Matthew R. Redinbo, Philip Potter, Stephen Kirby   +6 more
openalex   +1 more source

Abnormally high plasma concentrations of M-4, the active metabolite of edoxaban, at the onset of acute kidney injury in a patient receiving rifampin and clarithromycin: a case report

Journal of Pharmaceutical Health Care and Sciences
Background Edoxaban, the only factor Xa inhibitor with active metabolites, is metabolized by carboxylesterase-1 to its main active metabolite, M-4, which is a substrate of organic anion transporting polypeptide 1B1 (OATP1B1) and is excreted in bile and ...
Junichi Nakagawa, Keinosuke Ishido, Norihisa Kimura, Hayato Nagase, Yusuke Wakasa, Satoshi Yokoyama, Kayo Ueno, Kenichi Hakamada, Takenori Niioka   +8 more
doaj   +1 more source

Crystal Structures of Human Carboxylesterase 1 in Covalent Complexes with the Chemical Warfare Agents Soman and Tabun^,

, 2007
Christopher D. Fleming, Carol C. Edwards, Stephen D. Kirby, Donald M. Maxwell, Philip M. Potter, Douglas M. Cerasoli, Matthew R. Redinbo   +6 more
openalex   +2 more sources

Synergistic role of specificity proteins and upstream stimulatory factor 1 in transactivation of the mouse carboxylesterase 2/microsomal acylcarnitine hydrolase gene promoter [PDF]

, 2004
Tomomi Furihata, Masakiyo Hosokawa, Tetsuo Satoh, Kan Chiba   +3 more
openalex   +1 more source

Response to Comments on “Anti-Influenza Prodrug Oseltamivir Is Activated by Carboxylesterase Human Carboxylesterase 1, and the Activation Is Inhibited by Antiplatelet Agent Clopidogrel”

, 2007
Deshi Shi, Jian Yang, Dongfang Yang, Edward L. LeCluyse, Chris Black, You Li, Fatemeh Akhlaghi, Bingfang Yan   +7 more
openalex   +2 more sources

Carboxylesterase 1 directs the metabolic profile of dendritic cells to a reduced inflammatory phenotype [PDF]

Ahmed M I Elfiky, Jessica López Canñizares, Jiarong Li, Andrew Y. F. Li Yim, Arthur J. Verhoeven, Mohammed Ghiboub, Wouter J. de Jonge   +6 more
openalex   +1 more source

Effects of Toxicologically Relevant Xenobiotics and the Lipid-Derived Electrophile 4-Hydroxynonenal on Macrophage Cholesterol Efflux: Silencing Carboxylesterase 1 Has Paradoxical Effects on Cholesterol Uptake and Efflux [PDF]

, 2014
Matthew K. Ross, Abdolsamad Borazjani, Lee C. Mangum, Ran Wang, J. Allen Crow   +4 more
openalex   +1 more source

Conserved ProtonationPattern in the Extended ActiveSite of Human Carboxylesterase 1 and Its Impact on Enzyme Catalysis

Zijian Huang (10776416), Zelin Wu (4593856), Suitian Lai (17980535), Xiabin Chen (428601), Junjun Liu (674159)   +4 more
openalex   +2 more sources

Ester Prodrug NLRP3 Inflammasome Inhibitor NT-0796 is Brain Active due to Activation by Local Expression of Carboxylesterase-1. [PDF]

ACS Chem Neurosci
Digby Z, Diamond C, Wescott H, Smolak P, Thornton P, Lindsay N, Gabel CA, Clarke N, Watt AP.   +8 more
europepmc   +1 more source

An in vitro evaluation of common botanical extracts on carboxylesterase 1 catalytic activity. [PDF]

Drug Metab Dispos
Melchert PW, Zhang Q, Raeuscher JM, Gurley BJ, Markowitz JS.   +4 more
europepmc   +1 more source