Results 61 to 70 of about 27,172,362 (207)

Quantitative Analysis Reveals Hitchhiking Drives Polysorbate Hydrolase Persistence Via Host Cell Protein–Antibody Interactions

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Polysorbate‐degrading host cell proteins (HCPs) represent a critical challenge in the manufacturing of monoclonal antibody therapeutics due to their potential to persist during downstream processing. While their enzymatic activity has been characterized, the role of direct HCP‐mAb interactions, particularly those involving polysorbate ...
Melanie Maier, Lukas Griesinger, Matthias Franzreb, Simon Kluters   +3 more
wiley   +1 more source

Bolstering cholesteryl ester hydrolysis in liver: A hepatocyte-targeting gene delivery strategy for potential alleviation of atherosclerosis [PDF]

, 2017
Current atherosclerosis treatment strategies primarily focus on limiting further cholesteryl esters (CE) accumulation by reducing endogenous synthesis of cholesterol in the liver.
Ghosh, Shobha, He, Hongliang, Korzun, William J., Lancina, Michael G., III, Wang, Jing, Yang, Hu   +5 more
core   +2 more sources

Individualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics [PDF]

, 2018
Since its clinical introduction in 1998, the topoisomerase I inhibitor irinotecan has been widely used in the treatment of solid tumors, including colorectal, pancreatic, and lung cancer.
Bins, S. (Sander), Goey, A.K.L. (Andrew K. L.), Man, F.M. (Femke) de, Mathijssen, A.H.J. (Ron), Schaik, R.H.N. (Ron) van   +4 more
core   +6 more sources

Carboxylesterase 1-Mediated Drug–Drug Interactions between Clopidogrel and Simvastatin

Biological & Pharmaceutical Bulletin, 2015
Patients with coronary artery disease often receive concurrent treatment with clopidogrel and a hydroxymethylglutaryl (HMG)-CoA reductase inhibitor medication. Accordingly, potential drug-drug interactions associated with the concomitant use of these agents present an area of concern.
Xinwen, Wang, Hao-Jie, Zhu, John Seth, Markowitz   +2 more
openaire   +3 more sources

ProTides for Antiviral Activity Beyond Liver Cells

Chemistry – A European Journal, EarlyView.
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel, Adrian Humboldt, Heeyoung Kim, Carl J. M. Schölzel, Ralf Bartenschlager, Clemens Richert   +5 more
wiley   +1 more source

A personal 360° view of applications of ‘biomimetic’ molecular recognition

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract Molecular recognition between biological molecules has formed the basis for innumerable applications in biotechnology for the last seven decades or so. Techniques such as affinity chromatography, solid‐phase and aqueous two‐phase extraction, affinity precipitation, biomimetic catalytic systems, biosensors and molecular imprinting all exploit ...
Christopher R Lowe
wiley   +1 more source

Biology, physiology and gene expression of grasshopper Oedaleus asiaticus exposed to diet stress from plant secondary compounds [PDF]

, 2017
This study was supported by the National Natural Science Foundation of China, 31672485, the Earmarked Fund for China Agriculture Research System, CARS-35-07, and the Innovation Project of Chinese Academy of Agricultural Science.We studied the role of ...
Cao, Guangchun, Huang, Xunbing, Ma, Jingchuan, Nong, Xiangqun, Qin, Xinghu, Tu, Xiongbing, Wang, Guangjun, Zhang, Zehua   +7 more
core   +1 more source

Control failure risk, resistance and enzymatic activity of neurotoxic insecticides in Brazilian populations of Leucoptera coffeella (Lepidoptera: Lyonetiidae)

Pest Management Science, EarlyView.
Bioassays of 36 Leucoptera coffeella populations revealed resistance to neurotoxic insecticides, control failures of ≤62.9% and enzyme activity variation, with particularly high GST and low AChE levels. Abstract Background Leucoptera coffeella is a key pest of coffee crops in Brazil, causing significant damage by mining coffee leaves.
Daianna P. Costa, Carlos G. da Cruz, Ryan F. S. e Silva, Liliane E. Visôtto, Jesús E. Gomez, Marisol Giraldo‐Jaramillo, Flávio L. Fernandes   +6 more
wiley   +1 more source

Toxic Phenolic Glycosides From \u3ci\u3ePopulus:\u3c/i\u3e Physiological Adaptations of the Western North American Tiger Swallowtail Butterfly, \u3ci\u3ePapilio Rutulus\u3c/i\u3e (Lepidoptera: Papilionidae) [PDF]

, 2017
The phenolic glycosides tremulacin and salicortin found in quaking aspen, Populus tremuloides, and other members of the Salicaceae, are known to be toxic to larvae of the Eastern tiger swallowtail butterfly, Papilio glaucus, but not to the Canadian tiger
Lindroth, Richard L, Nitao, James K, Scriber, J. Mark   +2 more
core   +2 more sources

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source