Results 41 to 50 of about 15,347 (200)
Correction to "Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Nongenetic Regulators". [PDF]
Drug Metab Dispos, 2020 europepmc +4 more sources
PLoS ONE, 2022 Dimethyl fumarate (DMF) is a first-line prodrug for the treatment of relapsing-remitting multiple sclerosis (RRMS) that is completely metabolized to monomethyl fumarate (MMF), the active metabolite, before reaching the systemic circulation.
Bing Yang +5 more
doaj +3 more sources
Carbon nanomaterial functionalization with pesticide-detoxifying carboxylesterase [PDF]
, 2022 Four carbon materials, spent coffee-ground biochar, carbon black, short CNTs, and nitrogen-doped few-layer graphene (N-graphene) were tested for their functionalization with a commercial carboxylesterase.
Dondero, F +6 more
core +1 more source
CARBOXYLESTERASES IN ENANTIOSELECTIVE SYNTHESIS OF ORGANIC COMPOUNDS [PDF]
Biotechnologia Acta, 2013 The classification, structure, and mechanism of catalytic action of carboxylesterase of different origin are presented in the review. The prospects of carboxylesterases application for metabolism and both several drugs and prodrugs activation ...
E. A. Shesterenko +3 more
doaj +1 more source
Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny [PDF]
Drug Metabolism and Disposition, 2016 Human hepatic carboxylesterase 1 and 2 (CES1 and CES2) are important for the disposition of ester- and amide-bond-containing pharmaceuticals and environmental chemicals. CES1 and CES2 ontogeny has not been well characterized, causing difficulty in addressing concerns regarding juvenile sensitivity to adverse outcomes associated with exposure to certain
Ronald N Hines +2 more
openaire +2 more sources
Human Carboxylesterase 2 in Cocaine Metabolism
, 2021 Increased hydrolysis of cocaine to non-toxic compounds is a promising way to prevent cocaine-induced toxicity. However, the short half-life of cocaine in the blood and the rapid conversion in the body to the hydrolysis-resistant metabolite ...
Alexandra T.P., Carvalho +2 more
core +1 more source
Baboon carboxylesterases 1 and 2: sequences, structures and phylogenetic relationships with human and other primate carboxylesterases [PDF]
Journal of Medical Primatology, 2009 AbstractBackground Carboxylesterase (CES) is predominantly responsible for the detoxification of a wide range of drugs and narcotics, and catalyze several reactions in cholesterol and fatty acid metabolism. Studies of the genetic and biochemical properties of primate CES may contribute to an improved understanding of human disease, including ...
Holmes, Roger S +3 more
openaire +3 more sources
Application of lactic acid bacteria producing antifungal substance and carboxylesterase on whole crop rice silage with different dry matter [PDF]
Animal Bioscience, 2021 Objective This study was conducted to investigate effects of antifungal substance and carboxylesterase-producing inoculant on fermentation indices and rumen degradation kinetics of whole crop rice (WCR) silage ensiled at different dry matter (DM ...
Seong Shin Lee +7 more
doaj +1 more source
, 2021 Reengineered variants of a hyperthermophilic carboxylesterase with improved product yield in the synthesis of poly(ε-caprolactone) and triblock poly(ε-caprolactone)-co-poly(ethylene glycol)Methods: Quantum Mechanics/Molecular Mechanics Molecular ...
Derek J., Quinn +8 more
core +1 more source
Frontiers in Microbiology, 2023 IntroductionCPT11 (Irinotecan; 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin) is an important camptothecin-based broad-spectrum anticancer prodrug.
Yang Li +6 more
doaj +1 more source