Results 31 to 40 of about 15,347 (200)
Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Nongenetic Regulators. [PDF]
Drug Metab Dispos, 2020 Carboxylesterase (CES) 1 is the most abundant drug-metabolizing enzyme in human livers, comprising approximately 1% of the entire liver proteome. CES1 is responsible for 80%-95% of total hydrolytic activity in the liver and plays a crucial role in the metabolism of a wide range of drugs (especially ester-prodrugs), pesticides, environmental pollutants,
Her L, Zhu HJ.
europepmc +6 more sources
The COVID‐19 Medicine Remdesivir Is Therapeutically Activated by Carboxylesterase‐1, and Excessive Hydrolysis Increases Cytotoxicity [PDF]
Hepatology Communications, 2021 Yue Shen, William Eades, Bingfang Yan
doaj +2 more sources
BiomoleculesOnly a few halophilic archaea producing carboxylesterases have been reported. The limited research on biocatalytic characteristics of archaeal esterases is primarily due to their very low production in native organisms.
Nestor David Ortega-de la Rosa +4 more
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Functional Study of Carboxylesterase 1 Protein Isoforms. [PDF]
Proteomics, 2019 Abstract Carboxylesterase 1 (CES1) is a primary human hepatic hydrolase involved in hydrolytic biotransformation of numerous medications. Considerable interindividual variability in CES1 expression and activity has been consistently reported. Four isoforms of the CES1 protein are produced by alternative splicing (AS).
Wang X, Shi J, Zhu HJ.
europepmc +4 more sources
In vitro inhibition of carboxylesterase 1 by Kava (Piper methysticum) Kavalactones. [PDF]
Chem Biol Interact, 2022 Kava refers to the extracts from the rhizome of the plant Piper methysticum which is of particular significance to various indigenous cultures in the South Pacific region. Kavalactones are the active constituents of kava products and are associated with sedative and anxiolytic effects.
Melchert PW +5 more
europepmc +3 more sources
The Influence of Cannabidiol on the Pharmacokinetics of Methylphenidate in Healthy Subjects
Medical Cannabis and Cannabinoids, 2022 Introduction: Cannabidiol (CBD) is a widely utilized nonpsychoactive cannabinoid available as an over-the-counter supplement, a component of medical cannabis, and a prescriptive treatment of childhood epilepsies.
John S. Markowitz +6 more
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Toxins, 2023 Fumonisins (FBs) are mycotoxins that threaten public health and food safety worldwide. Enzymatic degradation of Fumonisin B1 (FB1) through decarboxylation has attracted much attention, whereas application of FB1 carboxylesterase in detoxification ...
Lixiang Jiang +6 more
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Pharmaceutics, 2021 ProTide technology is a powerful tool for the design of nucleoside/nucleotide analog prodrugs. ProTide prodrug design improves cell permeability and enhances intracellular activation.
Jiapeng Li +3 more
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A Comprehensive Functional Assessment of Carboxylesterase 1 Nonsynonymous Polymorphisms. [PDF]
Drug Metab Dispos, 2017 Carboxylesterase 1 (CES1) is the predominant human hepatic hydrolase responsible for the metabolism of many clinically important medications. CES1 expression and activity vary markedly among individuals; and genetic variation is a major contributing factor to CES1 interindividual variability.
Wang X +5 more
europepmc +4 more sources
Pharmaceutics, 2021 IMMH-010 is an ester prodrug of YPD-29B, a potent programmed cell death ligand 1 (PD-L1) inhibitor. The metabolism of IMMH-010 was investigated and compared in various species.
Yuchen Wang +10 more
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