Results 31 to 40 of about 22,222 (249)

A Comprehensive Functional Assessment of Carboxylesterase 1 Nonsynonymous Polymorphisms. [PDF]

Drug Metab Dispos, 2017
Carboxylesterase 1 (CES1) is the predominant human hepatic hydrolase responsible for the metabolism of many clinically important medications. CES1 expression and activity vary markedly among individuals; and genetic variation is a major contributing factor to CES1 interindividual variability.
Wang X, Rida N, Shi J, Wu AH, Bleske BE, Zhu HJ.   +5 more
europepmc   +4 more sources

Correction to "Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Nongenetic Regulators". [PDF]

Drug Metab Dispos, 2020
europepmc   +4 more sources

Metabolism and Interspecies Variation of IMMH-010, a Programmed Cell Death Ligand 1 Inhibitor Prodrug

Pharmaceutics, 2021
IMMH-010 is an ester prodrug of YPD-29B, a potent programmed cell death ligand 1 (PD-L1) inhibitor. The metabolism of IMMH-010 was investigated and compared in various species.
Yuchen Wang, Xiao Liu, Xiaowen Zou, Shuting Wang, Lijun Luo, Yuke Liu, Kai Dong, Xiaoqing Yao, Yan Li, Xiaoguang Chen, Li Sheng   +10 more
doaj   +1 more source

Alcohol inhibits the metabolism of dimethyl fumarate to the active metabolite responsible for decreasing relapse frequency in the treatment of multiple sclerosis

PLoS ONE, 2022
Dimethyl fumarate (DMF) is a first-line prodrug for the treatment of relapsing-remitting multiple sclerosis (RRMS) that is completely metabolized to monomethyl fumarate (MMF), the active metabolite, before reaching the systemic circulation.
Bing Yang, Robert B. Parker, Bernd Meibohm, Zaid H. Temrikar, Ashish Srivastava, S. Casey Laizure   +5 more
doaj   +3 more sources

CARBOXYLESTERASES IN ENANTIOSELECTIVE SYNTHESIS OF ORGANIC COMPOUNDS [PDF]

Biotechnologia Acta, 2013
The classification, structure, and mechanism of catalytic action of carboxylesterase of different origin are presented in the review. The prospects of carboxylesterases application for metabolism and both several drugs and prodrugs activation ...
E. A. Shesterenko, I. I. Romanovska, O. V. Sevastyanov, S. A. Andronat   +3 more
doaj   +1 more source

Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny [PDF]

Drug Metabolism and Disposition, 2016
Human hepatic carboxylesterase 1 and 2 (CES1 and CES2) are important for the disposition of ester- and amide-bond-containing pharmaceuticals and environmental chemicals. CES1 and CES2 ontogeny has not been well characterized, causing difficulty in addressing concerns regarding juvenile sensitivity to adverse outcomes associated with exposure to certain
Ronald N Hines, Pippa M Simpson, D. Gail McCarver   +2 more
openaire   +2 more sources

Application of lactic acid bacteria producing antifungal substance and carboxylesterase on whole crop rice silage with different dry matter [PDF]

Animal Bioscience, 2021
Objective This study was conducted to investigate effects of antifungal substance and carboxylesterase-producing inoculant on fermentation indices and rumen degradation kinetics of whole crop rice (WCR) silage ensiled at different dry matter (DM ...
Seong Shin Lee, Dimas Hand Vidya Paradhipta, Hyuk Jun Lee, Young Ho Joo, Hyeon Tak Noh, Jeong Seok Choi, Keum Bae Ji, Sam Churl Kim   +7 more
doaj   +1 more source

Structural insights into catalytical capability for CPT11 hydrolysis and substrate specificity of a novel marine microbial carboxylesterase, E93

Frontiers in Microbiology, 2023
IntroductionCPT11 (Irinotecan; 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin) is an important camptothecin-based broad-spectrum anticancer prodrug.
Yang Li, Yang Li, Zhen Rong, Zhengyang Li, Henglin Cui, Jixi Li, Xue-Wei Xu   +6 more
doaj   +1 more source

Combined Ensemble Docking and Machine Learning in Identification of Therapeutic Agents with Potential Inhibitory Effect on Human CES1

Molecules, 2019
The human carboxylesterase 1 (CES1), responsible for the biotransformation of many diverse therapeutic agents, may contribute to the occurrence of adverse drug reactions and therapeutic failure through drug interactions.
Eliane Briand, Ragnar Thomsen, Kristian Linnet, Henrik Berg Rasmussen, Søren Brunak, Olivier Taboureau   +5 more
doaj   +1 more source

Pharmacogenomic assessment of carboxylesterases 1 and 2

Genomics, 2004
Human carboxylesterases 1 and 2 (CES1 and CES2) catalyze the hydrolysis of many exogenous compounds. Alterations in carboxylesterase sequences could lead to variability in both the inactivation of drugs and the activation of prodrugs. We resequenced CES1 and CES2 in multiple populations (n = 120) to identify single-nucleotide polymorphisms and ...
Sharon, Marsh, Ming, Xiao, Jinsheng, Yu, Ranjeet, Ahluwalia, Matthew, Minton, Robert R, Freimuth, Pui-Yan, Kwok, Howard L, McLeod   +7 more
openaire   +2 more sources