Results 11 to 20 of about 15,347 (200)

Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism [PDF]

Acta Pharmaceutica Sinica B, 2023
The mammalian carboxylesterase 1 (Ces1/CES1) family comprises several enzymes that hydrolyze many xenobiotic chemicals and endogenous lipids. To investigate the pharmacological and physiological roles of Ces1/CES1, we generated Ces1 cluster knockout ...
Changpei Gan, Jing Wang, Alejandra Martínez-Chávez, Michel Hillebrand, Niels de Vries, Joke Beukers, Els Wagenaar, Yaogeng Wang, Maria C. Lebre, Hilde Rosing, Sjoerd Klarenbeek, Rahmen Bin Ali, Colin Pritchard, Ivo Huijbers, Jos H. Beijnen, Alfred H. Schinkel   +15 more
doaj   +4 more sources

Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1. [PDF]

PLoS ONE, 2015
Human Carboxylesterase 1 (hCES1) is the key liver microsomal enzyme responsible for detoxification and metabolism of a variety of clinical drugs. To analyse the role of the single N-linked glycan on the structure and activity of the enzyme, authentically
Victoria Arena de Souza, David J Scott, Joanne E Nettleship, Nahid Rahman, Michael H Charlton, Martin A Walsh, Raymond J Owens   +6 more
doaj   +6 more sources

Catalytic Hydrolysis Mechanism of Cocaine by Human Carboxylesterase 1: An Orthoester Intermediate Slows Down the Reaction [PDF]

Molecules, 2019
Human carboxylesterase 1 (hCES1) is a major carboxylesterase in the human body and plays important roles in the metabolism of a wide variety of substances, including lipids and drugs, and therefore is attracting more and more attention from areas ...
Maocai Yan, Zhen Zhang, Zhaoming Liu, Chunyan Zhang, Jingchang Zhang, Shuai Fan, Zhaoyong Yang   +6 more
doaj   +3 more sources

Fluorine impairs carboxylesterase 1-mediated hydrolysis of T-2 toxin and increases its chondrocyte toxicity [PDF]

Frontiers in Nutrition, 2022
BackgroundT-2 toxin is recognized as one of the high-risk environmental factors for etiology and pathogenesis of Kashin-Beck disease (KBD). Previous evidence indicates decreased serum fluorine level in KBD patients.
Yumeng Jia, Sirong Shi, Bolun Cheng, Shiqiang Cheng, Li Liu, Peilin Meng, Xuena Yang, Xiaoge Chu, Yan Wen, Feng Zhang, Xiong Guo   +10 more
doaj   +2 more sources

Enhanced triacylglycerol catabolism by carboxylesterase 1 promotes aggressive colorectal carcinoma. [PDF]

J Clin Invest, 2021
The ability to adapt to low-nutrient microenvironments is essential for tumor cell survival and progression in solid cancers, such as colorectal carcinoma (CRC). Signaling by the NF-κB transcription factor pathway associates with advanced disease stages and shorter survival in patients with CRC.
Capece D, D'Andrea D, Begalli F, Goracci L, Tornatore L, Alexander JL, Di Veroli A, Leow SC, Vaiyapuri TS, Ellis JK, Verzella D, Bennett J, Savino L, Ma Y, McKenzie JS, Doria ML, Mason SE, Chng KR, Keun HC, Frost G, Tergaonkar V, Broniowska K, Stunkel W, Takats Z, Kinross JM, Cruciani G, Franzoso G.   +26 more
europepmc   +12 more sources

Discovery of triterpenoids as potent dual inhibitors of pancreatic lipase and human carboxylesterase 1 [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Pancreatic lipase (PL) is a well-known key target for the prevention and treatment of obesity. Human carboxylesterase 1A (hCES1A) has become an important target for the treatment of hyperlipidaemia.
Jing Zhang, Qiu-Sha Pan, Xing-Kai Qian, Xiang-Lu Zhou, Ya-Jie Wang, Rong-Jing He, Le-Tian Wang, Yan-Ran Li, Hong Huo, Cheng-Gong Sun, Lei Sun, Li-Wei Zou, Ling Yang   +12 more
doaj   +2 more sources

Carboxylesterase 1 and Precision Pharmacotherapy [PDF]

, 2021
Carboxylesterase 1 (CES1) is a major phase I drug-metabolizing enzyme, responsible for 80-95% of total hydrolytic activity in human livers. CES1 plays a crucial role in the metabolism of a wide range of drugs, pesticides, environmental pollutants, and endogenous compounds.
Her, Lucy
openaire   +3 more sources

Identification and Expression Profiles of Six Transcripts Encoding Carboxylesterase Protein in Vitis flexuosa Infected with Pathogens

The Plant Pathology Journal, 2016
Plants protect themselves from pathogen attacks via several mechanisms, including hypersensitive cell death. Recognition of pathogen attack by the plant resistance gene triggers expression of carboxylesterase genes associated with hypersensitive response.
Md. Zaherul Islam, Hae Keun Yun
doaj   +2 more sources

Immobilization of active human carboxylesterase 1 in biomimetic silica nanoparticles [PDF]

Biotechnology Progress, 2011
AbstractThe encapsulation of proteins in biomimetic silica has recently been shown to successfully maintain enzymes in their active state. Organophosphate (OP) compounds are used as pesticides as well as potent chemical warfare nerve agents. Because these toxicants are life threatening, we sought to generate biomimetic silicas capable of responding to ...
Jonathan S, Edwards, Amar, Kumbhar, Adam, Roberts, Andrew C, Hemmert, Carol C, Edwards, Philip M, Potter, Matthew R, Redinbo   +6 more
openaire   +4 more sources

Autotransporter domain-dependent enzymatic analysis of a novel extremely thermostable carboxylesterase with high biodegradability towards pyrethroid pesticides

Scientific Reports, 2017
The EstPS1 gene, which encodes a novel carboxylesterase of Pseudomonas synxantha PS1 isolated from oil well-produced water, was cloned and sequenced.
Xianghai Cai, Wei Wang, Lin Lin, Dannong He, Gang Huang, Yaling Shen, Wei Wei, Dongzhi Wei   +7 more
doaj   +2 more sources