Hepatocyte‐Specific Expression of Human Carboxylesterase 1 Attenuates Diet‐Induced Steatohepatitis and Hyperlipidemia in Mice [PDF]
Hepatology Communications, 2020 Rodents have at least five carboxylesterase 1 (Ces1) genes, whereas there is only one CES1 gene in humans, raising the question as to whether human CES1 and mouse Ces1 genes share the same functions.
Yanyong Xu +6 more
doaj +4 more sources
Catalytic Hydrolysis Mechanism of Cocaine by Human Carboxylesterase 1: An Orthoester Intermediate Slows Down the Reaction [PDF]
Molecules, 2019 Human carboxylesterase 1 (hCES1) is a major carboxylesterase in the human body and plays important roles in the metabolism of a wide variety of substances, including lipids and drugs, and therefore is attracting more and more attention from areas ...
Maocai Yan +6 more
doaj +4 more sources
Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels. [PDF]
PLoS ONE, 2014 Metabolic syndrome, characterized by obesity, hyperglycemia, dyslipidemia and hypertension, increases the risks for cardiovascular disease, diabetes and stroke.
Jiesi Xu +6 more
doaj +4 more sources
Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1. [PDF]
PLoS ONE, 2015 Human Carboxylesterase 1 (hCES1) is the key liver microsomal enzyme responsible for detoxification and metabolism of a variety of clinical drugs. To analyse the role of the single N-linked glycan on the structure and activity of the enzyme, authentically
Victoria Arena de Souza +6 more
doaj +4 more sources
Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism [PDF]
Acta Pharmaceutica Sinica B, 2023 The mammalian carboxylesterase 1 (Ces1/CES1) family comprises several enzymes that hydrolyze many xenobiotic chemicals and endogenous lipids. To investigate the pharmacological and physiological roles of Ces1/CES1, we generated Ces1 cluster knockout ...
Changpei Gan +15 more
doaj +2 more sources
Fluorine impairs carboxylesterase 1-mediated hydrolysis of T-2 toxin and increases its chondrocyte toxicity [PDF]
Frontiers in Nutrition, 2022 BackgroundT-2 toxin is recognized as one of the high-risk environmental factors for etiology and pathogenesis of Kashin-Beck disease (KBD). Previous evidence indicates decreased serum fluorine level in KBD patients.
Yumeng Jia +10 more
doaj +2 more sources
Discovery of triterpenoids as potent dual inhibitors of pancreatic lipase and human carboxylesterase 1 [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Pancreatic lipase (PL) is a well-known key target for the prevention and treatment of obesity. Human carboxylesterase 1A (hCES1A) has become an important target for the treatment of hyperlipidaemia.
Jing Zhang +12 more
doaj +2 more sources
Engineering, 2022 Accurately assessing and tracking the progression of liver-specific injury remains a major challenge in the field of biomarker research. Here, we took a retrospective validation approach built on the mutuality between serum and tissue biomarkers to ...
Qiusha Pan +10 more
doaj +2 more sources
An in vitro evaluation of kratom (Mitragyna speciosa) on the catalytic activity of carboxylesterase 1 (CES1). [PDF]
Chem Biol Interact, 2023 Melchert PW +5 more
europepmc +3 more sources
Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers. [PDF]
Clin Transl Sci, 2021 Wang X +6 more
europepmc +3 more sources