BiomoleculesOnly a few halophilic archaea producing carboxylesterases have been reported. The limited research on biocatalytic characteristics of archaeal esterases is primarily due to their very low production in native organisms.
Nestor David Ortega-de la Rosa +4 more
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Increased serum carboxylesterase-1 levels are associated with metabolic dysfunction associated steatotic liver disease and metabolic syndrome in children with obesity. [PDF]
Ital J PediatrWang H +9 more
europepmc +3 more sources
A structural examination of agrochemical processing by human carboxylesterase 1
Journal of Pesticide Science, 2021 Human carboxylesterase 1 (hCE1) is the primary carboxylesterase expressed in the liver. This critical member of the phase I drug metabolism pathway detoxifies a wide-range of endobiotics, xenobiotics, and agrochemicals. To date, more than a dozen X-ray crystal structures have been elucidated of hCE1 in complex with a broad spectrum of ligands ...
Matthew R. Redinbo, Andrew Hemmert
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In vitro inhibition of carboxylesterase 1 by Kava (Piper methysticum) Kavalactones. [PDF]
Chem Biol Interact, 2022 Kava refers to the extracts from the rhizome of the plant Piper methysticum which is of particular significance to various indigenous cultures in the South Pacific region. Kavalactones are the active constituents of kava products and are associated with sedative and anxiolytic effects.
Melchert PW +5 more
europepmc +3 more sources
Global inactivation of carboxylesterase 1 (Ces1/Ces1g) protects against atherosclerosis in Ldlr -/- mice. [PDF]
Sci Rep, 2017 Xu J, Xu Y, Xu Y, Yin L, Zhang Y.
europepmc +3 more sources
Baboon carboxylesterases 1 and 2: sequences, structures and phylogenetic relationships with human and other primate carboxylesterases [PDF]
Journal of Medical Primatology, 2009 AbstractBackground Carboxylesterase (CES) is predominantly responsible for the detoxification of a wide range of drugs and narcotics, and catalyze several reactions in cholesterol and fatty acid metabolism. Studies of the genetic and biochemical properties of primate CES may contribute to an improved understanding of human disease, including ...
Roger S. Holmes +3 more
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The Influence of Cannabidiol on the Pharmacokinetics of Methylphenidate in Healthy Subjects
Medical Cannabis and Cannabinoids, 2022 Introduction: Cannabidiol (CBD) is a widely utilized nonpsychoactive cannabinoid available as an over-the-counter supplement, a component of medical cannabis, and a prescriptive treatment of childhood epilepsies.
John S. Markowitz +6 more
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Toxins, 2023 Fumonisins (FBs) are mycotoxins that threaten public health and food safety worldwide. Enzymatic degradation of Fumonisin B1 (FB1) through decarboxylation has attracted much attention, whereas application of FB1 carboxylesterase in detoxification ...
Lixiang Jiang +6 more
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Enhanced triacylglycerol catabolism by carboxylesterase 1 promotes aggressive colorectal carcinoma. [PDF]
J Clin Invest, 2021 The ability to adapt to low-nutrient microenvironments is essential for tumor cell survival and progression in solid cancers, such as colorectal carcinoma (CRC). Signaling by the NF-κB transcription factor pathway associates with advanced disease stages and shorter survival in patients with CRC.
Capece D +26 more
europepmc +8 more sources
Pharmaceutics, 2021 ProTide technology is a powerful tool for the design of nucleoside/nucleotide analog prodrugs. ProTide prodrug design improves cell permeability and enhances intracellular activation.
Jiapeng Li +3 more
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