Results 71 to 80 of about 22,222 (249)

Functional Analysis of a Carboxylesterase Gene Associated With Isoprocarb and Cyhalothrin Resistance in Rhopalosiphum padi (L.)

Frontiers in Physiology, 2018
Carboxylesterase (CarE) is an important class of detoxification enzymes involved in insecticide resistance. However, the molecular mechanism of CarE-mediated insecticide resistance in Rhopalosiphum padi, a problematic agricultural pest, remains largely ...
Kang Wang, Yanna Huang, Xinyu Li, Maohua Chen   +3 more
doaj   +1 more source

A carboxylesterase, Esterase-6, modulates sensory physiological and behavioral response dynamics to pheromone in Drosophila [PDF]

, 2012
Conclusions: Our study presents evidence that Est-6 plays a role in the physiological and behavioral dynamics of sex pheromone response in Drosophila males and supports a role of Est-6 as an odorant-degrading enzyme (ODE) in male antennae.
Chertemps, Thomas, Dekker, Teun, Durand, Nicolas, Francois, Adrien, Lucas, Philippe, Maibeche-Coisne, Martine, Rosell, Gloria   +6 more
core  

Effects of cocaethylene on dopamine and serotonin synthesis in Long–Evans and Sprague–Dawley brains [PDF]

, 1998
We examined the behavioral and neurochemical effects of cocaethylene treatment in Long–Evans ( LE). and Sprague–Dawley (SD) rats. Cocaethylene-induced behaviors were significantly less in LE rats.
Baumann, Dr. M.H., Horowitz, Dr. J.M., Kristal, Dr. M.B., Torres, Dr. G.   +3 more
core   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Simultaneously Predicting the Pharmacokinetics of CES1-Metabolized Drugs and Their Metabolites Using Physiologically Based Pharmacokinetic Model in Cirrhosis Subjects

Pharmaceutics
Hepatic carboxylesterase 1 (CES1) metabolizes numerous prodrugs into active ingredients or direct-acting drugs into inactive metabolites. We aimed to develop a semi-physiologically based pharmacokinetic (semi-PBPK) model to simultaneously predict the ...
Xin Luo, Zexin Zhang, Ruijing Mu, Guangyu Hu, Li Liu, Xiaodong Liu   +5 more
doaj   +1 more source

Molecular Marker to Identify Two Stingless Bee Species: Tetragonisca angustula and Tetragonisca fiebrigi (Hymenoptera, Meliponinae)

Sociobiology, 2014
Tetragonisca angustula and T. fiebrigi esterases were biochemically characterized by their inhibition pattern and thermostability. Workers of both species were collected from nests at the State University of Maringa. In T.
Ana Lúcia Paz Barateiro Stuchi, Vagner de A. Arnaut de Toledo, Denise Alves Lopes, Liriana Belizário Cantagalli, Maria Claudia Colla Ruvolo-Takasusuki   +4 more
doaj   +1 more source

Malathion Resistance in Larvae of Some Southern Minnesota Populations of the Indianmeal Moth,\u3ci\u3e Plodia Interpunctella\u3c/i\u3e (Lepidoptera: Pyralidae), Infesting Bulk-Stored Shelled Corn [PDF]

, 2017
Larvae of 21 field collected populations of the Indianmeal moth, Plodia interpunctella, infesting stored shelled corn in southern Minnesota were tested for their susceptibility to malathion in the laboratory.
Harein, P. K, Subramanyam, Bh., Sumner, W. A, II   +2 more
core   +1 more source

Structural and biochemical characterisation of Archaeoglobus fulgidus esterase reveals a bound CoA molecule in the vicinity of the active site [PDF]

, 2016
A new carboxyl esterase, AF-Est2, from the hyperthermophilic archaeon Archaeoglobus fulgidus has been cloned, over-expressed in Escherichia coli and biochemically and structurally characterized. The enzyme has high activity towards short- to medium-chain
Finnigan, W, Harmer, NJ, Isupov, MN, Kengen, SWM, Levisson, M, Littlechild, JA, sayer, C, van der Oost, J   +7 more
core   +1 more source

Multisite Promiscuity in the Processing of Endogenous Substrates by Human Carboxylesterase 1 [PDF]

Journal of Molecular Biology, 2006
Human carboxylesterase 1 (hCE1) is a drug- and endobiotic-processing serine hydrolase that exhibits relatively broad substrate specificity. It has been implicated in a variety of endogenous cholesterol metabolism pathways including the following apparently disparate reactions: cholesterol ester hydrolysis (CEH), fatty acyl Coenzyme A hydrolysis (FACoAH)
Sompop, Bencharit, Carol C, Edwards, Christopher L, Morton, Escher L, Howard-Williams, Peter, Kuhn, Philip M, Potter, Matthew R, Redinbo   +6 more
openaire   +2 more sources

Treatment of cholinergic‐induced status epilepticus with polytherapy targeting GABA and glutamate receptors

Epilepsia Open, 2023
Despite new antiseizure medications, the development of cholinergic‐induced refractory status epilepticus (RSE) continues to be a therapeutic challenge as pharmacoresistance to benzodiazepines and other antiseizure medications quickly develops.
Jerome Niquet, Donna Nguyen, Marcio deAraujo Furtado, Lucille Lumley   +3 more
doaj   +1 more source