Results 71 to 80 of about 15,347 (200)

In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites [PDF]

Drug Metabolism and Disposition, 2019
The escalating use of medical cannabis and significant recreational use of cannabis in recent years has led to a higher potential for metabolic interactions between cannabis or one or more of its components and concurrently used medications. Although there have been a significant number of in vitro and in vivo assessments of the effects of cannabis on ...
Yuli, Qian, Xinwen, Wang, John S, Markowitz   +2 more
openaire   +2 more sources

Characterization, sub-cellular localization and expression profiling of the isoprenylcysteine methylesterase gene family in Arabidopsis thaliana

, 2010
Background: Isoprenylcysteine methylesterases (ICME) demethylate prenylated protein in eukaryotic cell. Until now, knowledge about their molecular information, localization and expression pattern is largely unavailable in plant species.
Wang, H.Z., Huizhong Wang, Ping Lan, Li, W.F., Lan, P., Wujun Ma, Wenfeng Li, Ma, W.   +7 more
core   +1 more source

Human carboxylesterase 1 active site structure.

, 2013
Active site of human carboxylesterase 1 covalently inhibited via S221 with cyclosarin (magenta) [8]. The other catalytic residues, in addition to S221, are H468 and E354 (yellow), and are surrounded by hydrophobic residues (grey surface) including V146 ...
Steven L. Lewis (354519), Matthew R. Redinbo (93591), Carol C. Edwards (354521), Tamara C. Otto (350617), Philip M. Potter (23125), Douglas M. Cerasoli (350618), C. Linn Cadieux (354524), John R. Cashman (354526), Lyudmila Tsurkan (354523), Shane A. Kasten (354525), Roberto A. Chica (109101), Stephen L. Mayo (109096), Monika Wierdl (354512), Jonathan S. Edwards (354516), Andrew C. Hemmert (354510)   +14 more
core   +1 more source

Simultaneously Predicting the Pharmacokinetics of CES1-Metabolized Drugs and Their Metabolites Using Physiologically Based Pharmacokinetic Model in Cirrhosis Subjects

Pharmaceutics
Hepatic carboxylesterase 1 (CES1) metabolizes numerous prodrugs into active ingredients or direct-acting drugs into inactive metabolites. We aimed to develop a semi-physiologically based pharmacokinetic (semi-PBPK) model to simultaneously predict the ...
Xin Luo, Zexin Zhang, Ruijing Mu, Guangyu Hu, Li Liu, Xiaodong Liu   +5 more
doaj   +1 more source

Molecular Marker to Identify Two Stingless Bee Species: Tetragonisca angustula and Tetragonisca fiebrigi (Hymenoptera, Meliponinae)

Sociobiology, 2014
Tetragonisca angustula and T. fiebrigi esterases were biochemically characterized by their inhibition pattern and thermostability. Workers of both species were collected from nests at the State University of Maringa. In T.
Ana Lúcia Paz Barateiro Stuchi, Vagner de A. Arnaut de Toledo, Denise Alves Lopes, Liriana Belizário Cantagalli, Maria Claudia Colla Ruvolo-Takasusuki   +4 more
doaj   +1 more source

Environmental Identification of Novel Enzymes for Polyurethane and Polyamide Degradation

Angewandte Chemie International Edition, EarlyView.
Heteroatom‐containing plastics such as polyurethanes and nylons are produced at scale yet remain largely unrecycled. Biocatalysts offer a promising route to depolymerization under mild conditions. Here, we present a screening platform for the discovery of novel polyurethane‐ and nylon‐degrading enzymes from environmental samples and demonstrate ...
Malthe Kjær Bendtsen, Andreas Møllebjerg, Samuel Peña‐Díaz, Rosie Graham, Nicolai Claus Petersen, Bjørk Nolsøe Isaksen, Mathias Carstensen, Martin B. Johansen, Andreas Sommerfeldt, Allan R. Petersen, Iddi Khamisi Chuma, Cecilie Ryberg, Thomas Rea Wittenborn, Virginia Gichuru, Huabing Wang, Carsten Scavenius, Alexander Sandahl, Daniel E. Otzen   +17 more
wiley   +1 more source

Novel Genetic Variants in Carboxylesterase 1 Predict Severe Early-Onset Capecitabine-Related Toxicity

, 2017
An important concern with the anticancer drug capecitabine (Cp), an oral prodrug of 5‐fluorouracil, are dose‐limiting adverse effects, in particular hand‐foot syndrome (HFS) and diarrhea.
Mueller, D, Milesi, S, Hamzic, Seid, D Kummer, S Milesi, CR Largiader, D Mueller, Aebi, S, M Joerger, Kummer, Dominic, Amstutz, Ursula, Largiadèr, Carlo Rodolfo, S Aebi, Joerger, M, S Hamzic, U Amstutz   +15 more
core   +1 more source

Discovery and Redesign of a Family VIII Carboxylesterase with High (S)Selectivity toward Chiral sec-Alcohols

, 2022
Highly enantioselective lipase has been widely utilized in the preparation of versatile enantiopure chiral sec-alcohols through kinetic or dynamic kinetic resolution.
Seongsoon Park (3195249), Areum Park, Seongsoon Park, Areum Park (3195255)   +3 more
core   +1 more source

Treatment of cholinergic‐induced status epilepticus with polytherapy targeting GABA and glutamate receptors

Epilepsia Open, 2023
Despite new antiseizure medications, the development of cholinergic‐induced refractory status epilepticus (RSE) continues to be a therapeutic challenge as pharmacoresistance to benzodiazepines and other antiseizure medications quickly develops.
Jerome Niquet, Donna Nguyen, Marcio deAraujo Furtado, Lucille Lumley   +3 more
doaj   +1 more source

The interplay between molecular architecture, pharmacology, and suspected adverse drug reactions associated with nonsteroidal androgen antagonists in the United Kingdom

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to correlate potential links between the suspected adverse drug reaction (ADR) profile of licensed nonsteroidal androgen receptor antagonists (NSARA) with their unique chemical properties and known off‐target polypharmacology. Methods Physicochemical and polypharmacology data were curated from the Electronic Medicines Compendium ...
Simrit Dhillon, Albert A. Antolin, Alan M. Jones   +2 more
wiley   +1 more source