Results 21 to 30 of about 184,100 (261)

Adamantane carboxylic acids demonstrate mitochondrial toxicity consistent with oil sands-derived naphthenic acids

Environmental Advances, 2021
Naphthenic acids (NAs) are thought to be a primary cause of toxicity of oil sands process-affected water (OSPW). The purpose of this study was to determine if commercially available adamantane carboxylic acids act by mitrochondrial mechanisms similar to ...
Kate I. Rundle, Mahmoud S. Sharaf, Don Stevens, Collins Kamunde, Michael R. van den Heuvel   +4 more
doaj   +1 more source

Heterocycles [h]-Fused Onto 4-Oxoquinoline-3-Carboxylic Acid, Part VIII [1]. Convenient Synthesis and Antimicrobial Properties of Substituted Hexahydro[1,4]diazepino[2,3-h]quinoline-9-carboxylic acid and Its Tetrahydroquino[7,8-b]benzodiazepine Analog

Molecules, 2008
[1,4]Diazepino[2,3-h]quinolone carboxylic acid 3 and its benzo-homolog tetrahydroquino[7,8-b]benzodiazepine-3-carboxylic acid 5 were prepared via PPAcatalyzed thermal lactamization of the respective 8-amino-7-substituted-1,4-dihydroquinoline-3-carboxylic
Yusuf M. Al-Hiari, Rana Abu-Dahab, Mustafa M. El-Abadelah   +2 more
doaj   +1 more source

Lipoxygenase and Its Relationship with Ethylene During Ripening of Genetically Modified Tomato (Solanum lycopersicum)

Food Technology and Biotechnology, 2020
Research background. TomloxB is the main isoform of lipoxygenase associated with ripening and senescence of fruits. On the other hand, ethylene, a gaseous hormone, is essential for the regulation of ripening in climacteric fruits like tomatoes.
Arturo Alberto Velázquez- López, Javier De La Cruz-Medina, Hugo Sergio García, Gilber Vela-Gutiérrez, Cristóbal Torres-Palacios, Elizabeth León-García   +5 more
doaj   +1 more source

Diamondoids are not forever: microbial biotransformation of diamondoid carboxylic acids

Microbial Biotechnology, 2020
Summary Oil sands process‐affected waters (OSPW) contain persistent, toxic naphthenic acids (NAs), including the abundant yet little‐studied diamondoid carboxylic acids.
Benjamin D. Folwell, Terry J. McGenity, Corinne Whitby   +2 more
doaj   +1 more source

Crystal structure of [1,1′:3′,1′′-terphenyl]-2′,3,3′′-tricarboxylic acid

Acta Crystallographica Section E: Crystallographic Communications, 2015
The asymmetric unit of the title compound, C21H14O6, comprises two symmetrically independent molecules that form a locally centrosymmetric hydrogen-bonded dimer, with the planes of the corresponding carboxylic acid groups rotated by 15.8 (1) and 17.5 (1)°
Daniel A. Decato, Orion B. Berryman
doaj   +1 more source

Crystal structure of zymonic acid and a redetermination of its precursor, pyruvic acid

Acta Crystallographica Section E: Crystallographic Communications, 2019
The structure of zymonic acid (systematic name: 4-hydroxy-2-methyl-5-oxo-2,5-dihydrofuran-2-carboxylic acid), C6H6O5, which had previously eluded crystallographic determination, is presented here for the first time.
Dominik Heger, Alexis J. Eugene, Sean R. Parkin, Marcelo I. Guzman   +3 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Valorization of Lignin by Partial Wet Oxidation Using Sustainable Heteropoly Acid Catalysts

Molecules, 2017
The production of carboxylic acids by partial wet oxidation of alkali lignin at elevated temperatures and pressures was studied experimentally. Two different heteropoly acids, phosphotungstic acid (H3PW12O40) and phosphomolybdic acid (H3PMo12O40), were ...
Abayneh Getachew Demesa, Arto Laari, Mika Sillanpää, Tuomas Koiranen   +3 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Visible Light–Induced Decarboxylative Radical Addition of Heteroaromatic Carboxylic Acids to Alkenes at Room Temperature in Two‐Molecule Photoredox System

ChemistryOpen
The photoinduced decarboxylative radical addition of aryl carboxylic acids, including heteroaromatic carboxylic acids, to electron‐deficient alkenes is achieved in a two‐molecule photoredox system using a combination of biphenyl (BP) and 9,10 ...
Daisuke Suzuki, Ryoga Hashimoto, Toshiki Furutani, Mugen Yamawaki, Hirotsugu Suzuki, Yasuharu Yoshimi   +5 more
doaj   +1 more source