Results 31 to 40 of about 63,707 (195)

New Forms of Bovine Carboxypeptidase B and Their Homologous Relationships to Carboxypeptidase A [PDF]

Proceedings of the National Academy of Sciences, 1971
Two new forms of carboxypeptidase B have been isolated from spontaneously activated bovine pancreatic juice. The fully active enzymes contain an internal split at residues 92-93 and 95-96, respectively. Sequenator analysis of the amino terminal segments of the two chains of the enzyme has extended the sequence information by 51 amino acid residues ...
G R, Reeck, K A, Walsh, M A, Hermodson, H, Neurath   +3 more
openaire   +2 more sources

Characterization, Recombinant Production and Structure-Function Analysis of NvCI, A Picomolar Metallocarboxypeptidase Inhibitor from the Marine Snail Nerita versicolor

Marine Drugs, 2019
A very powerful proteinaceous inhibitor of metallocarboxypeptidases has been isolated from the marine snail Nerita versicolor and characterized in depth.
Giovanni Covaleda-Cortés, Martha Hernández, Sebastián Alejandro Trejo, Manuel Mansur, Sergi Rodríguez-Calado, Javier García-Pardo, Julia Lorenzo, Josep Vendrell, María Ángeles Chávez, Maday Alonso-del-Rivero, Francesc Xavier Avilés   +10 more
doaj   +1 more source

In vivo effects of bradykinin B2 receptor agonists with varying susceptibility to peptidases.

Frontiers in Pharmacology, 2016
We reported evidence of bradykinin (BK) regeneration from C-terminal extended BK sequences that behave as peptidase-activated B2 receptor (B2R) agonists.
Mélissa eJean, Lajos eGera, Xavier eCharest-Morin, François eMarceau, Hélène eBachelard   +4 more
doaj   +1 more source

From DCPD to NTCP: The long journey towards identifying a functional hepatitis B virus receptor [PDF]

Clinical and Molecular Hepatology, 2015
Hepatitis B virus (HBV) is the prototype of hepatotropic DNA viruses (hepadnaviruses) infecting a wide range of human and non-human hosts. Previous studies with duck hepatitis B virus (DHBV) identified duck carboxypeptidase D (dCPD) as a host specific ...
Jisu Li, Shuping Tong
doaj   +1 more source

A Preliminary Study of the Activation of Endogenous Pancreatic Exocrine Enzymes during Automated Porcine Islet Isolation

Cell Transplantation, 1999
The activation of endogenous pancreatic enzymes during automated pancreas digestion may be detrimental to islet isolation. In this report we assessed the activation of trypsin, chymotrypsin, elastase, carboxypeptidases A and B, phospholipase A 2 , and ...
S. A. White MD, FRCS, H. Djaballah, D. P. Hughes, D. L. Roberts, H. H. Contractor, S. Pathak, N. J. M. London   +6 more
doaj   +1 more source

Nitrogen Supply and Host-Plant Genotype Modulate the Transcriptomic Profile of Plasmodiophora brassicae

Frontiers in Microbiology, 2021
Nitrogen fertilization can affect the susceptibility of Brassica napus to the telluric pathogen Plasmodiophora brassicae. Our previous works highlighted that the influence of nitrogen can strongly vary regarding plant cultivar/pathogen strain ...
Kévin Gazengel, Yoann Aigu, Christine Lariagon, Mathilde Humeau, Antoine Gravot, Maria J. Manzanares-Dauleux, Stéphanie Daval   +6 more
doaj   +1 more source

Proteomic profiling of sweat in patients with cystic fibrosis provides new insights into epidermal homoeostasis

Skin Health and Disease, 2023
Background A high proportion of patients with Cystic Fibrosis (CF) also present the rare skin disease aquagenic palmoplantar keratoderma. A possible link between this condition and absence of a functional CF Transmembrane conductance Regulator protein in
Matthieu Cornet, Thao Nguyen‐Khoa, Mairead Kelly‐Aubert, Vincent Jung, Frédérique Chedevergne, Muriel Le Bourgeois, Laura Aoust, Kévin Roger, Chiara Ida Guerrera, Isabelle Sermet‐Gaudelus   +9 more
doaj   +1 more source

Identification of Genes and miRNAs Associated with TAFI-Related Thrombosis: An in Silico Study

Biomolecules, 2023
Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) is a carboxypeptidase B-like proenzyme encoded by the CPB2 gene. After thrombin activation, TAFI downregulates fibrinolysis, thus linking the latter with coagulation.
Erasmia Rouka, Sotirios G. Zarogiannis, Chrissi Hatzoglou, Konstantinos I. Gourgoulianis, Foteini Malli   +4 more
doaj   +1 more source

The nature of the ligand's side chain interacting with the S1'-subsite of metallocarboxypeptidase T (from Thermoactinomyces vulgaris) determines the geometry of the tetrahedral transition complex.

PLoS ONE, 2019
The carboxypeptidase T (CPT) from Thermoactinomyces vulgaris has an active site structure and 3D organization similar to pancreatic carboxypeptidases A and B (CPA and CPB), but differs in broader substrate specificity.
Valery Kh Akparov, Vladimir I Timofeev, Galina E Konstantinova, Ilyas G Khaliullin, Inna P Kuranova, Tatiana V Rakitina, Vytas Švedas   +6 more
doaj   +1 more source

Serum-Mediated Cleavage of Bacillus anthracis Protective Antigen Is a Two-Step Process That Involves a Serum Carboxypeptidase

mSphere, 2018
Much of our understanding of the activity of anthrax toxin is based on in vitro systems, which delineate the interaction between Bacillus anthracis toxins and the cell surface.
David L. Goldman, Edward Nieves, Antonio Nakouzi, Johanna Rivera, Ei Ei Phyu, Than Htut Win, Jacqueline M. Achkar, Arturo Casadevall   +7 more
doaj   +1 more source