Results 81 to 90 of about 63,707 (195)

The Cyclic Antimicrobial Peptide C-LR18 Has Enhanced Antibacterial Activity, Improved Stability, and a Longer Half-Life Compared to the Original Peptide

Antibiotics
Background: LR18 is an α₋helical AMP with high antimicrobial activity, low hemolytic activity, and low cytotoxicity. However, the susceptibility to degradation of the peptidase enzyme and a short half-life hinder its application as a therapeutic agent ...
Zhihua Pei, Qiaoxi Song, Jingqi Xu, Shuang Yu, Hongxia Ma   +4 more
doaj   +1 more source

Proteases Shape the Chlamydomonas Secretome: Comparison to Classical Neuropeptide Processing Machinery

Proteomes, 2018
The recent identification of catalytically active peptidylglycine α-amidating monooxygenase (PAM) in Chlamydomonas reinhardtii, a unicellular green alga, suggested the presence of a PAM-like gene and peptidergic signaling in the last eukaryotic ...
Raj Luxmi, Crysten Blaby-Haas, Dhivya Kumar, Navin Rauniyar, Stephen M. King, Richard E. Mains, Betty A. Eipper   +6 more
doaj   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Correction to "C-Terminal Arginine-Selective Cleavage of Peptides as a Method for Mimicking Carboxypeptidase B". [PDF]

Org Lett, 2023
Prosser LC, Talbott JM, Garrity RP, Raj M.   +3 more
europepmc   +1 more source

Signal Amplification in the HPT Axis—Evidence for Its Existence, Location, Significance, and Molecular Mechanisms

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Thyroid hormones (THs) are under negative feedback regulation via the hypothalamic–pituitary‐thyroid (HPT) axis. How this axis operates to keep the circulating THs within a narrow physiological range is not well understood quantitatively. Led by the design principle of robust homeostatic feedback control, here we review and synthesize the ...
Li Jing, Sarahna A. Moyd, Qiang Zhang
wiley   +1 more source

Determination of digestive proteolytic profile in the larvae of Dyspessa palidata (Staudinger) (Lepidoptera: Cossidae)

Journal of Entomological and Acarological Research, 2015
Digestive proteolytic profile was determined in the larvae of Dyspessa palidata (Staudinger), which is the most important pest of Alliaceae in Europe and Iran.
M. Mardani-Talaee, A. Zibaee
doaj   +1 more source

C-Terminal Arginine-Selective Cleavage of Peptides as a Method for Mimicking Carboxypeptidase B. [PDF]

Org Lett, 2023
Prosser LC, Talbott JM, Garrity RP, Raj M.   +3 more
europepmc   +1 more source

Subclass III SnRK2 Kinases Coordinate Starch and Storage Protein Synthesis During Maize Kernel Development

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2279-2299, April 2026.
ABSTRACT Enhancing both starch and protein accumulation is a key strategy for improving maize yield and quality. Achieving this goal requires an in‐depth understanding of the regulatory mechanisms that integrate these pathways. Here, we demonstrate that functionally redundant subclass III SNF1‐related protein kinase 2s (SnRK2s) act as central ...
Yayun Wang, Tiandan Long, Changqing Mao, Shan Feng, Qiang Liao, Yufeng Hu, Junjie Zhang, Hanmei Liu, Yinghong Liu, Xiujun Fan, Lei Gao, Canmei Cun, Binjie Xu, Daqiu Zhao, Jing Wang, Yubi Huang, Yangping Li   +16 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, Volume 600, Issue 5, Page 631-643, March 2026.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Small size apolipoprotein(a) isoforms enhance inflammatory and proteolytic potential of collagen-primed monocytes

Lipids in Health and Disease, 2019
Background Atherosclerosis is an inflammatory process involving activation of monocytes recruited by various chemoattractant factors, among which lipoprotein(a) and its specific apolipoprotein apo(a). Lp(a) contains a specific apolipoprotein apo(a) which
Nadia Sabbah, Stéphane Jaisson, Roselyne Garnotel, Eduardo Anglés-Cano, Philippe Gillery   +4 more
doaj   +1 more source