Results 121 to 130 of about 1,077,378 (364)

Discrimination of Membrane Antigen Affinity by B cells Requires Dominance of Kinetic Proofreading over Serial Triggering [PDF]

arXiv, 2010
B cells receptor (BCR) signaling in response to membrane-bound antigen increases with antigen affinity, a process known as affinity discrimination. We use computational modeling to show that B cell affinity discrimination requires that kinetic proofreading predominate over serial engagement.
arxiv  

A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors

Clinical Cancer Research, 2016
Purpose: CEA TCB is a novel IgG-based T-cell bispecific (TCB) antibody for the treatment of CEA-expressing solid tumors currently in phase I clinical trials (NCT02324257). Its format incorporates bivalent binding to CEA, a head-to-tail fusion of CEA- and
M. Bacac, T. Fauti, J. Sam, S. Colombetti, Tina Weinzierl, D. Ouaret, W. Bodmer, Steffi Lehmann, T. Hofer, R. Hosse, E. Moessner, O. Ast, P. Bruenker, Sandra Grau-Richards, Teilo H. Schaller, Annette Seidl, C. Gerdes, M. Perro, V. Nicolini, N. Steinhoff, S. Dudal, S. Neumann, Thomas von Hirschheydt, Christiane Jaeger, J. Saro, V. Karanikas, C. Klein, P. Umaña   +27 more
semanticscholar   +1 more source

Ubiquitous Nuclear Factors Bind Specifically to a 5′-Region Conserved in Carcinoembryonic Antigen-Related Genes [PDF]

, 1992
We recently cloned members of the murine carcinoembryonic antigen (CEA) gene family, some of which are differentially expressed during placental development.
Rudert, Fritz, Thompson, John A., Zimmermann, Wolfgang   +2 more
core   +1 more source

A computational study of the statistical mechanics of antibody-antigen conformations [PDF]

arXiv, 2004
We describe the representation of the chemical affinity between the antigen-combining site of the immunoglobulin molecule and the antigen molecule as the probability of the two molecules existing in a bound state. Our model is based on the identification of shape attractors in the configuration space for the joint antibody / antigen combining site ...
arxiv  

Updated management of malignant biliary tract tumors: an illustrative review [PDF]

, 2016
The management of malignant biliary tumors (MBTs) is complex and requires a multidisciplinary approach. Guidelines and methods of staging for biliary tumors have recently been released by main international societies, altering the clinical and radiologic
Cannavale, Alessandro, Catalano, Carlo, Fanelli, Fabrizio, Fiocca, Fausto, Gazzetti, Marianna, Maher, Ben, Santoni, Mariangela   +6 more
core   +1 more source

A General Theory for Direct Quantitative Analysis of Antigen [PDF]

arXiv, 2011
A theory for direct quantitative analysis of an antigen is proposed. It is based on a potential homogenous immunoreaction system. It establishes an equation to describe the concentration change of the antigen and antibody complex. A maximum point is found in the concentration profile of the complex which can be used to calculate the concentration of ...
arxiv  

Personalized Risk Assessment in Never, Light, and Heavy Smokers in a prospective cohort in Taiwan. [PDF]

, 2016
The objective of this study was to develop markedly improved risk prediction models for lung cancer using a prospective cohort of 395,875 participants in Taiwan.
Chow, Wong-Ho, Cunningham, Sonia, Gu, Jian, Huang, Maosheng, Huff, Chad, Lippman, Scott M, Pu, Xia, Roth, Jack A, Tsai, MinKwang, Tsao, Chwen Keng, Wen, Chi Pang, Wen, Christopher, Wu, Shuanbei, Wu, Xifeng, Ye, Yuanqing   +14 more
core   +1 more source

Occult mucin-producing urothelial-type adenocarcinoma of the prostate with elevated serum levels of carcinoembryonic antigen and carbohydrate antigen 19-9: Report of an autopsy-proven case

Urology Case Reports, 2019
Mucin-producing urothelial-type adenocarcinoma of the prostate (MPUAP) is a rare, aggressive neoplasm thought to originate from the prostatic urethral urothelium.
Keisuke Nonaka, Yoko Matsuda, Mototsune Kakizaki, Shoichiro Takakuma, Tomoyasu Matsubara, Shigeo Murayama, Toshiyuki Ishiwata, Masashi Kameyama, Kazuto Ogura, Sumiko Kobayashi, Tomio Arai   +10 more
doaj  

Three timepoint perioperative CEA levels are a prognostic factor for recurrence after adjuvant chemotherapy in patients with Stage II and III colorectal cancer

Annals of Gastroenterological Surgery, EarlyView.
This study aimed to investigate the relationship between the three timepoint perioperative CEA (ttpCEA) calculated at three timepoints and recurrence during the perioperative period in Stage II and III colorectal cancer (CRC) patients. A total of 538 patients were included for the training data and 329 patients for validation data, and 5‐y time‐to ...
Shodai Mizuno, Kohei Shigeta, Ryosuke Hara, Kyoko Sakamoto, Jumpei Nakadai, Hideo Baba, Hiroto Kikuchi, Yoko Adachi, Takehiro Shimada, Hirofumi Suzumura, Kiyoaki Sugiura, Shimpei Matsui, Ryo Seishima, Koji Okabayashi, Yuko Kitagawa   +14 more
wiley   +1 more source

The use of quantum dots to amplify antigen detection [PDF]

arXiv, 2017
Proposal to develop an Improved immunological assay employing primary IgG antibodies and secondary IgM antibodies labeled with quantum dots to amplify antigen detection.
arxiv