Results 71 to 80 of about 83,128 (268)
Advanced Science, EarlyView.We identify an antagonistic ubiquitin circuit that controls cellular permissiveness to multiple coronaviruses. The deubiquitinase USP7 stabilizes the epigenetic regulator KDM6A to upregulate viral receptors, while the E3 ligase RNF40 degrades KDM6A by catalyzing K6/K11‐ubiquitin chains of KDM6A for autophagic degradation.
Meng‐Zhuo Huang +9 more
wiley +1 more source
مجلة بغداد للعلومColorectal cancer (CRC) is a disease that begins exclusively in the colon or rectum and is caused by an abnormal proliferation of glandular epithelial cells in the colon. Carbohydrate antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA), calcium (Ca),
Fenik Ahmed Nadir, Zeyan Abdullah Ali
doaj +1 more source
Tumor Biology, 2018 In late-stage metastatic colorectal cancer, difficult treatment decisions should incorporate a thorough evaluation of the patient’s general condition and subject for shared decision making.
Karen-Lise Garm Spindler +8 more
doaj +1 more source
Personalized Risk Assessment in Never, Light, and Heavy Smokers in a prospective cohort in Taiwan. [PDF]
, 2016 The objective of this study was to develop markedly improved risk prediction models for lung cancer using a prospective cohort of 395,875 participants in Taiwan.
Chow, Wong-Ho +14 more
core +1 more source
Advanced Science, EarlyView.This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey +6 more
wiley +1 more source
New biomarkers for the diagnosis of pleural effusion
The Egyptian Journal of Bronchology, 2022 Background Persistent undiagnosed effusion is present in approximately 15% of all causes of exudative effusion. Pleural effusion caused by immunoglobulin G4 (IgG4) is a new type of pleural effusion.
Raafat T. El-Sokkary +3 more
doaj +1 more source
Carcinoembryonic antigen in pancreatitis [PDF]
Cancer, 1973 Serum specimens of 42 patients with pancreatitis (36, alcoholic; 6, nonalcoholic) were analyzed for carcinoembryonic antigen (CEA). Eighteen patients (43%), all with alcoholic etiology, had positive assays. Of the CEA-positive patients, 12 had mild-to-moderate liver disease, and 6 were clinically free of liver disease.
R, Delwiche, N, Zamcheck, N, Marcon
openaire +2 more sources
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Serum carcinoembryonic antigen elevation in benign lung diseases
Scientific Reports, 2021 Carcinoembryonic antigen (CEA) is not only used to aid the diagnosis of lung cancer, but also help monitor recurrence and determine the prognosis of lung cancer as well as evaluate the therapeutic efficacy for lung cancer.
Yi Yang +7 more
doaj +1 more source
Carcinoembryonic Antigen in Faeces [PDF]
BMJ, 1972 Carcinoembryonic antigen (C.E.A.) was detected in the faeces of 5 out of 10 healthy volunteers, 12 out of 18 patients suffering from gastrointestinal cancer (including 10 out of 11 cases of colonic cancer), and 3 out of 13 patients suffering from non-neoplastic disease. It is suggested that C.E.A.
D L, Freed, G, Taylor
openaire +2 more sources