Results 91 to 100 of about 2,174 (124)
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Carcinogenicity of sterigmatocystin
Food and Cosmetics Toxicology, 1968Abstract The mycotoxin, sterigmatocystin, was administered to rats in doses of 0·15–2·25 mg/day by gavage or in the diet for 52 wk. Eight rats which received a high dose (1·5–2·25 mg/day) of sterigmatocystin died between wk 5 and 18, while 39 out of the 50 treated rats surviving to wk 42 eventually developed hepatocellular carcinoma. Of these, 31 had
J. J. van der Watt, I.F.H. Purchase
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Dietary Carcinogens and Anti-Carcinogens
Journal of Toxicology: Clinical Toxicology, 1984The scientific understanding of cancer and degenerative disease is being aided by new methodologies which are now used to approach the problem of environmental and occupational carcinogens and anticarcinogens. This paper reviews these powerful new tools and relates them to "natural" mutagens and carcinogens in food.
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Chemico-Biological Interactions, 2021
Current regulatory cancer risk assessment principles and practices assume a linear dose-response relationship-the linear no-threshold (LNT) model-that theoretically estimates cancer risks occurring following low doses of carcinogens by linearly extrapolating downward from experimentally determined risks at high doses.
Nicholas D. Priest +2 more
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Current regulatory cancer risk assessment principles and practices assume a linear dose-response relationship-the linear no-threshold (LNT) model-that theoretically estimates cancer risks occurring following low doses of carcinogens by linearly extrapolating downward from experimentally determined risks at high doses.
Nicholas D. Priest +2 more
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Reviews on Environmental Health, 1979
The study of bracken carcinogenicity affords an interesting example of the close alliance, with mutual benefit, between the work of veterinarians in the field and experimental research. On the one hand was the condition found in many parts of the world of bovine enzootic haematuria with uncertain aetiology and, on the other, the investigations ...
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The study of bracken carcinogenicity affords an interesting example of the close alliance, with mutual benefit, between the work of veterinarians in the field and experimental research. On the one hand was the condition found in many parts of the world of bovine enzootic haematuria with uncertain aetiology and, on the other, the investigations ...
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Carcinogens and Anticarcinogens
1986There is the potential for major progress in the prevention of cancer in the next 5 or 10 years. In the short term, progress in the prevention of cancer depends on a better understanding of some of the risk factors and antirisk factors for the major human cancers.
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Mutagens, Carcinogens, and Anti-Carcinogens
1982Mutagens and carcinogens in the environment represent a potential hazard, and it is important to screen large numbers of compounds and mixtures of compounds to which humans are exposed. However, it is Impractical for both technical and monetary reasons to do the bulk of mutagen screening by using mammals.
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Carcinogenicity and Modification of Carcinogenic Response by Antioxidants
1990Synthetic or naturally occurring antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), propyl gallate sodium L-ascorbate, and α-tocopherol have been widely used as food additives in various processed foods to prevent auto-oxidation of fatty acids.
Masao Hirose +3 more
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Nature, 1962
IT has been shown previously that cobalt metal powder suspended in fowl serum and injected intramuscularly into rats is a potent and rapid carcinogen. This metal produces mainly rhabdomyosarcomata1–3. Zinc and tungsten metal powders injected in the same way produce no tumours.
J. T. Dingle +3 more
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IT has been shown previously that cobalt metal powder suspended in fowl serum and injected intramuscularly into rats is a potent and rapid carcinogen. This metal produces mainly rhabdomyosarcomata1–3. Zinc and tungsten metal powders injected in the same way produce no tumours.
J. T. Dingle +3 more
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Environmental Research, 1979
Abstract Lindane is highly carcinogenic in rats and mice. Lindane induced benign and malignant neoplasms at all sites in male and female rats. Benign and malignant neoplasms of the endocrine organs were also increased. Carcinomas of the adrenal and pituitary were increased markedly in male and female rats.
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Abstract Lindane is highly carcinogenic in rats and mice. Lindane induced benign and malignant neoplasms at all sites in male and female rats. Benign and malignant neoplasms of the endocrine organs were also increased. Carcinomas of the adrenal and pituitary were increased markedly in male and female rats.
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Nature, 1954 THE effects of various metals on living cells in tissue culture are being investigated in this Laboratory, and a non-lethal disturbance of normal mitosis produced in chick fibroblasts by cobalt (as chloride) has already been reported1. This effect, which is characterized by the persistence of the nucleoli in mitotic cells throughout prophase into meta-,
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