Results 91 to 100 of about 238,323 (340)

POLE Deficiency Exacerbates Diesel Engine Exhaust‐Induced Genomic Instability and Malignant Transformation of Bronchial Epithelial Cells

Advanced Science, EarlyView.
This study establishes a diesel engine exhaust (DEE)‐induced malignant transformation model in bronchial epithelial cells. Whole genome sequencing（WGS） and RNA‐seq reveal DEE‐induced mutational signatures and gene expression profiles. Mechanistically, DEEaffect polymerase epsilon (POLE) and mismatch repair, driving genomic instability and promoting ...
Pimei Zhang, Zhaoxu Wu, Qiang Ju, Nuo Xu, Xian Chen, Hongguang Chen, Shuaishuai Yang, Jing Ji, Yanjie Zhao   +8 more
wiley   +1 more source

Oral squamous cell carcinoma: Effect of tobacco and alcohol on cancer location

Tobacco Induced Diseases
Introduction The underlying factors of oral squamous cell cancers (OSCC) have been elucidated, but studies have focused little on etiological differences in affected oral cavity sites.
Riikka Eloranta, Suvi-Tuuli Vilén, Arvi Keinänen, Tuula Salo, Ahmed Qannam, Ibrahim O. Bello, Johanna Snäll   +6 more
doaj   +1 more source

Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention.

Chemical Research in Toxicology, 2010
Tobacco carcinogen and toxicant biomarkers are metabolites or protein or DNA adducts of specific compounds in tobacco products. Highly reliable analytical methods, based mainly on mass spectrometry, have been developed and applied in large studies of ...
S. Hecht, Jian-Min Yuan, D. Hatsukami
semanticscholar   +1 more source

Scaffolding Protein ENH Promotes Tumor Angiogenesis and Growth Through Macrophage Recruitment and Polarization

Advanced Science, EarlyView.
In tumor cells, ENH prompts the interaction between YAP and KPNA2. This interaction enables YAP to translocate into the nucleus, where it enhances the transcription of CCL5. Consequently, this up‐regulation of CCL5 drives the infiltration of tumor‐associated macrophages (TAMs) and their polarization toward the M2 phenotype, ultimately facilitating ...
Yueli Shi, Zhiyong Xu, Huan Wang, Bufu Tang, Nueraili Maihemuti, Xinyuan Jiang, Xiuying Chen, Mingshu Xiao, Sujing Jiang, Yun Xu, Peng Xiao, Jiangnan Zhao, Kaiyue Zhang, Mengshu Li, Kai Wang   +14 more
wiley   +1 more source

Blood Lead (Pb) Levels as a Possible Marker of Cancer Risk in a Prospective Cohort of Women with Non-Occupational Exposure

Biomedicines
Background/Objectives: To correlate blood lead (Pb) levels with cancer risk in a prospective cohort of healthy women with non-occupational exposure to lead. We hypothesize that blood Pb levels can predict the risk of cancer in healthy women. Methods: The
Krzysztof Lubiński, Marcin R. Lener, Wojciech Marciniak, Jakub Pawłowski, Julia Sadzikowska, Adam Kiljańczyk, Milena Matuszczak, Piotr Baszuk, Sandra Pietrzak, Róża Derkacz, Marta Bryśkiewicz, Cezary Cybulski, Jacek Gronwald, Tadeusz Dębniak, Tomasz Huzarski, Steven A. Narod, Rodney J. Scott, Jan Lubiński   +17 more
doaj   +1 more source

Cigarette smoking, genetic variants in carcinogen-metabolizing enzymes, and colorectal cancer risk.

American Journal of Epidemiology, 2010
The risk of colorectal cancer associated with smoking is unclear and may be influenced by genetic variation in enzymes that metabolize cigarette carcinogens.
S. Cleary, M. Cotterchio, Ellen J. Q. Shi, S. Gallinger, P. Harper   +4 more
semanticscholar   +1 more source

The State of High‐Resolution Imaging of the Human Inner Ear: A Look Into the Black Box

Advanced Science, Volume 12, Issue 28, July 24, 2025.
High‐resolution imaging of the cochlea is challenged by numerous unique aspects of this organ, where sensorineural cells, crucial for hearing, are too small for conventional modalities like magnetic resonance imaging and computed tomography. This article reviews current imaging techniques, emerging technologies, and innovations aimed at improving ...
Shelley Batts, Nancy Pham, Guillermo Tearney, Konstantina M. Stankovic   +3 more
wiley   +1 more source

Plasma DNMT1 Activity for Assessing Tumor Burden and Predicting Neoadjuvant Therapy Response in Breast Cancer

Advanced Science, EarlyView.
In this work, a detection method is presented for the activity of plasma DNA methyltransferase 1 (DNMT1), namely DNMT1 Identification by Variable Activity (DIVA). DIVA can detect plasma DNMT1 at levels as low as 10−7 U mL−1, also it successfully evaluated tumor burden and predicted the neoadjuvant therapy responses of breast cancer patients.
Yingran Wang, Guozhi Zhang, Zhizhao Zhang, Mengsi Zhang, Jiao Chen, Ke Wang, Lu Liu, Jing Bao, Ming Chen, Xiaowei Qi, Mingxuan Gao   +10 more
wiley   +1 more source

TRAFFIC - RELATED CONCENTRATIONS OF BTEX, FORMALDEHYDE AND ACETALDEHYDE IN TEHRAN; CONCENTRATIONS AND SPATIAL VARIABILITY

Journal of Air Pollution and Health, 2018
Introduction: Traffic and mobile sources are possibly responsible to the most of the ambient volatile organic compounds (VOCs) in urban areas.
Mostafa Hadei, Abbas Shahsavani, Majid Kermani, Baharan Emam, Maryam Yarahmadi, Reza Bakhtiari   +5 more
doaj  

Harnessing the Immunomodulation of UV‐Exposed Keratinocyte Extracellular Vesicles for Inflammatory Disorder Treatment

Advanced Science, EarlyView.
Adopting a paradigm shift that transforms a known health hazard as a potential therapeutic asset, a novel therapeutic strategy is set out to investigate for inflammatory conditions by leveraging immunosuppressive properties of UV‐irradiated keratinocytes.
Lu Liu, Ding Yang, Jingsen Ji, Gengyou Li, Haoting Chen, Yuying Yao, Chenxing Fu, Fangling Liao, Jinzhao Liu, Yaming Zhang, Zechuan Li, Jing Zhang, Huike Ma, Jingxia Zhao, Ying‐Shi Sun, Weisheng Guo, Weiping Wang   +16 more
wiley   +1 more source