Results 91 to 100 of about 62,075 (266)

Learning with Patient Campaigners About a German Drug Scandal

Berichte zur Wissenschaftsgeschichte, EarlyView.
The West German drug Duogynon was internationally marketed as a “hormone pregnancy test” (HPT) between the 1950s and 1980s. In the late 1960s it came under suspicion for inducing miscarriage, spina bifida, and a spectrum of birth defects similar to those caused by the sedative thalidomide.
Jesse Olszynko‐Gryn, Anja Suter, Edmund Bolger, Birgit Nemec   +3 more
wiley   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Marine silicon for biomedical sustainability

BMEMat, EarlyView.
Schematic illustrating marine silicon for biomedical engineering. Abstract Despite momentous divergence from oceanic origin, human beings and marine organisms exhibit elemental homology through silicon utilization. Notably, silicon serves as a critical constituent in multiple biomedical processes.
Yahui Han, Zhibo Yang, Wei Xia, Chengtie Wu   +3 more
wiley   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Carcinogenesis Associated with Toxin Nephropathy: Proposed Mediation by Phosphate Toxicity

Cells
Although cancer is often considered a genetic disease, genotoxic damage to nuclear DNA caused by carcinogens is not always sufficient to stimulate cancer cell growth, suggesting that other etiological factors are involved.
Ronald B. Brown, John G. Mielke
doaj   +1 more source

Sustainability Assessment of Circular Strategies in the Agri‐Food Industry: The Case of Olive Mills' By‐Product Valorization

Business Strategy and the Environment, EarlyView.
ABSTRACT This study integrates multidimensional sustainability indicators into a unified assessment approach to evaluate circular strategies in agri‐food industry businesses. This methodological approach is applied to empirically examine the case of the olive oil industry's by‐product valorization.
David Polonio, Rubén Granado‐Díaz, José A. Gómez‐Limón, Anastasio J. Villanueva   +3 more
wiley   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Oxophilicity‐Driven Potential Window Engineering Enables Scalable and Low‐Emission Paired Electrosynthesis on Asymmetric CuOx@Ag Platform

Carbon and Hydrogen, EarlyView.
An asymmetric CuOx@Ag electrocatalyst platform enables paired electrochemical valorization of glycerol and 4‐nitrophenol, while effectively decoupling both half‐reactions from OER and HER. Ag‐mediated surface engineering expands the potential window and boosts reaction selectivity, achieving > 90% Faradaic efficiencies at both electrodes.
Xulai Gong, Linjie Zhao, Yongde Long, Hongwu Chen, Jiaxin Bai, Lei Chao, Xinyou Han, Baoguang Mao, Xianwei Liu, Yuanqing Shen, Wei Liu, Bowen Liu, Husitu Lin, Yang Song, Chuangang Hu   +14 more
wiley   +1 more source

Synthesizing polyethersulphone membranes with hybrid iron/nickel nanoparticles for dyes removal: An efficient biogenesis approach

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract Industrial wastewater contamination by azo dyes poses a significant environmental challenge. This study reports the green synthesis of bimetallic iron/nickel (Fe/Ni) nanoparticles using moringa leaf extract, which acted as both a reducing and capping agent, and their incorporation into polyethersulphone (PES) membranes to produce eco‐friendly ...
Qusay A. Almajras, Ahmed K. Hassan, Dahiru Lawal, Mohammed Awad, Raed A. Al‐Juboori, Muhammad Irfan, Muhammad Rafiq, Qusay F. Alsalhy   +7 more
wiley   +1 more source

Experimental methods in chemical engineering: Atomic absorption spectrometry—AAS

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract Elements absorb electromagnetic radiation (light) of a specific wavelength in proportion to the number of atoms in its path. As the atoms absorb this light energy, electrons rise from the ground state to an excited state. In atomic absorption spectrometry (AAS), high temperatures produce clouds of atoms from the sample (atomization) and ...
Emily Cintia Tossi de A. Costa, Jildimara de Jesus Santana, Viviane de Oliveira Campos, Felipe Fernandes Barbosa, Gregory S. Patience   +4 more
wiley   +1 more source