Results 101 to 110 of about 172,865 (359)

TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux

Advanced Science, EarlyView.
TRIM38, an E3 ubiquitin ligase, suppresses breast cancer progression by inhibiting proliferation, migration, and invasion. Downregulated in breast tumor, its loss correlates with poor prognosis. Mechanistically, TRIM38 mediates K63‐linked ubiquitination of SQSTM1/p62 at K420, disrupting SQSTM1‐LC3 interaction and blocking autophagic flux.
Shan Jiang, Lijuan Wang, Dianwen Han, Peng Su, Bing Chen, Wenjing Zhao, Tong Chen, Ning Zhang, Xiaolong Wang, Yiran Liang, Yaming Li, Chen Li, Xi Chen, Dan Luo, Qifeng Yang   +14 more
wiley   +1 more source

TRAFFIC - RELATED CONCENTRATIONS OF BTEX, FORMALDEHYDE AND ACETALDEHYDE IN TEHRAN; CONCENTRATIONS AND SPATIAL VARIABILITY

Journal of Air Pollution and Health, 2018
Introduction: Traffic and mobile sources are possibly responsible to the most of the ambient volatile organic compounds (VOCs) in urban areas.
Mostafa Hadei, Abbas Shahsavani, Majid Kermani, Baharan Emam, Maryam Yarahmadi, Reza Bakhtiari   +5 more
doaj  

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

Advanced Science, EarlyView.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng, Jia‐Jia Liang, Yun‐Feng Zhan, Wei‐Xun Wu, Wan‐Li Xu, Xiao‐Kun Zhang, Li‐Jun Cai, Fu‐Quan Jiang   +7 more
wiley   +1 more source

Unrecognized risks of nickel-related respiratory cancer among Canadian electrolysis workers

Scandinavian Journal of Work, Environment & Health, 2012
OBJECTIVES: Nickel compounds, inclusive of water-soluble salts, have been classified as human carcinogens by the International Agency for Research on Cancer (IARC).
Tom K Grimsrud, Aage Andersen
doaj   +1 more source

Monte Carlo Simulation in Environmental Risk Assessment--Science, Policy and Legal Issues [PDF]

, 1998
Dr. Poulter notes that agencies should anticipate judicial requirements for justification of Monte Carlo simulations and, meanwhile, should consider, e.g., whether their use will make risk assessment policy choices more opaque or ...
Poulter, Susan R.
core   +1 more source

Carcinogen-induced impairment of enzymes for replicative fidelity of DNA and the initiation of tumours [PDF]

, 2003
Leon P. Bignold
openalex   +1 more source

Coupling Nitrogenous Organic Wastewater Treatment and Biorefinery via N‐Cycling Bacterium

Advanced Science, EarlyView.
The vast reservoir of nitrogenous organic pollutants in industrial wastewaters can serve as untapped carbon‐nitrogen resources. This study employs the newly discovered Paracoccus sp. ZQW‐1 as a versatile chassis to simultaneously achieve N‐methylpyrrolidone (NMP) wastewater depuration and polyhydroxybutyrate (PHB) synthesis.
Ziqian Wang, Chunyu Du, Guanyu Zheng, Dahu Ding   +3 more
wiley   +1 more source

Mitigation of arsenic toxicity in rice grain through soil-water-plant continuum

Plant, Soil and Environment
Increased levels of the non-essential hazardous metalloid arsenic (As) in rice grains pose a threat to human health and the sustainability of the rice industry. In several counties, the average As contamination in polished rice has been detected to range
Okram Ricky Devi, Bibek Laishram, Abhijit Debnath, Gangadhara Doggalli, Nayanjyoti Ojha, Smita Agrawal, Kahkashan Perveen, Najat A. Bukhari, Kalyan Pathak, Samiron Dutta   +9 more
doaj   +1 more source

APC-β-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis. [PDF]

, 2020
Sporadic colorectal cancer initiates with mutations in APC or its degradation target β-catenin, producing TCF-dependent nuclear transcription driving tumorigenesis. The intestinal epithelial receptor, GUCY2C, with its canonical paracrine hormone guanylin,
Bashir, Babar, Blomain, Erik S, Caparosa, Ellen, Pattison, Amanda M, Rappaport, Jeffrey A, Snook, Adam E, Stem, Jonathan, Waldman, Scott A   +7 more
core   +1 more source

RETRACTED ARTICLE: Computer electromagnetic radiation carcinogenic doses based on Monte Carlo algorithm [PDF]

, 2018
Haoli Hou, Junhua Wang, Yi Xu, Zhijian Fang, Zhongyu Dai   +4 more
openalex   +1 more source