Results 101 to 110 of about 281,280 (268)

Activation of DNMT1 by Chemically Synthesized Dual‐Monoubiquitinated PAF15 Protein

Advanced Science, EarlyView.
DNA methyltransferase 1 (DNMT1) propagates DNA methylation patterns during replication and is stimulated by dual‐monoubiquitinated PCNA‐associated factor 15 (PAF15Ub2). We chemically synthesized PAF15Ub2 with native isopeptide linkages. Cryo‐EM analysis of DNMT1 bound to the synthetic PAF15Ub2 and hemimethylated DNA revealed an active conformation with
Sae Suzuki, Yuya Takahashi, Amika Kikuchi, Satomi Kori, Fumika Yoshitomi, Hiroshi Murakami, Kyohei Arita, Gosuke Hayashi   +7 more
wiley   +1 more source

Hypermutability in Carcinogenesis

Genetics, 1998
AbstractThe presence of numerous chromosomal changes and point mutations in tumors is well established. At least some of these changes play a role in the development of the tumors. It has been suggested that the number of these genetic changes requires that tumorigenesis involves an increase in mutation rate.
openaire   +2 more sources

Single‐Cell Map of Early Lung Adenocarcinoma Uncovers Invasion‐Associated Tertiary Lymphoid Structures

Advanced Science, EarlyView.
Early thoracic lesions are already heavily infiltrated by immune cells, yet these infiltrates largely consist of bystander T lymphocytes within an immunosuppressive microenvironment. Pathological invasion is strikingly associated with the neogenesis of T/B cell‐rich TLSs that predominantly remain immature.
Pengfei Ma, Chunming He, Mei‐Chun Cai, Jie Wu, Haijiao Lu, Shichao Zhou, Zhenfeng Zhang, Qing Zhang, Yunqing Chen, Jingyu Zang, Kaiyan Ye, Yu Shu, Chee Wai Chua, Hui Li, Yun Fan, Jing Wang, Zhuang Yu, Xinying Xue, Xiaojing Zhao, Guanglei Zhuang, Yujie Fu   +20 more
wiley   +1 more source

Associations of Patient Morphology and Venous Anatomy with Early Changes in Upper-Extremity Venous Blood Flow Following PICC Placement in Patients with Cancer: A Prospective Cohort Study

Vascular Health and Risk Management
Guodong Wang,1,* Yanfen Shen,2,* Yuan Yang,1,* Xinpeng Wang,2 Jing Dong,2 Xiaozheng Wang II,2 Yuanyuan Zheng,2 Jie Chen,2 Chun Wang,3 Xiaofang Meng,2 Feng Liu,2 Jinli Song,2 Jun Dong11Intensive Care Unit, Peking University Cancer ...
Wang G, Shen Y, Yang Y, Wang X, Dong J, Wang II X, Zheng Y, Chen J, Wang C, Meng X, Liu F, Song J, Dong J   +12 more
doaj  

A Celastrol–Platinum(IV) Nanoprodrug Couples Ferroptosis With Caspase‐Independent Pyroptosis to Enhance Anti‐PD‐1 Therapy in Colorectal Cancer

Advanced Science, EarlyView.
CPAN integrates celastrol‐driven oxidative stress with Pt(IV)‐induced DNA damage to couple ferroptosis with caspase‐independent pyroptosis. Celastrol disrupts the GSH/GPX4 axis and promotes lipid peroxidation, while Pt(IV)‐associated PARP/PARylation signaling facilitates full‐length GSDME oligomerization.
Huirong Li, Wenxiang Feng, Le Xin, Wu Zhong, Zhuhuai Peng, Zhihong Ke, Wenbin Zhou, Yutong Wu, Ying Chen, Hongwei Wang, Jidong Liu, Jinjun Ye, Weihong Guo   +12 more
wiley   +1 more source

Bacillus Licheniformis‐Induced Cognitive Decline in Mice Linking Gut Microbiota Dysbiosis, Metabolic Perturbations, and Hippocampal Neuroinflammation

Advanced Science, EarlyView.
Chronic oral administration of specific probiotic strains triggers gut microbiota dysbiosis and systemic metabolic perturbations in mice. Multi‐omics profiling reveals subsequent hippocampal glial remodeling and neuroinflammation, which are linked to cognitive impairment.
Yibin Lin, Afeng Wang, Hongchang Zhou, Yuliang Sun, Yingying Guo, Keyu Chen, Junhong Sun, Tinliang Lin, Zhaochen Huang, Xinhua Qiang, Jie He, Jianlin Lou, Yunliang Yao, Shengwen Shao, Yongliang Pan, Xiang Wang   +15 more
wiley   +1 more source

Biological Resectability in Colorectal Liver Metastases: A Nomogram‐Based Continuous Risk Model to Define Borderline Disease

Annals of Gastroenterological Surgery, EarlyView.
KRAS mutation demonstrated a prognostic impact according to primary tumor sidedness, independent of tumor morphology, in patients undergoing hepatectomy for colorectal liver metastases. A nomogram integrating biological and clinicopathological factors was developed to provide continuous biological risk assessment.
Yuzo Umeda, Toshiharu Mitsuhashi, Tomokazu Fuji, Toru Kojima, Takeshi Koujima, Tatsuo Matsuda, Daisuke Satoh, Masaru Inagaki, Kosei Takagi, Toshiyoshi Fujiwara   +9 more
wiley   +1 more source

Integrating APCS Score With Dual Biomarker Testing (FIT + mSEPT9) for Precision Risk Stratification and Predictive Modeling in High‐Risk Populations for Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
Asia‐Pacific Colorectal Screening (APCS) risk stratification was combined with quantitative fecal immunochemical test (FIT) and plasma methylated Septin9 to identify advanced colorectal neoplasia in a high‐risk cohort. The integrated model showed high apparent discrimination, while internal validation indicated a modest and uncertain incremental ...
WeiKang Ye, Wei Xu, WenTing Yu, Xiuping Wan, Liu He, Maoning Liu, XinMing Lei   +6 more
wiley   +1 more source

Clinically Informed Intelligent Classification of Ovarian Cancer Cells by Label‐Free Holographic Imaging Flow Cytometry

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Quantitative phase maps of single cells recorded in flow cytometry modality feed a hierarchical architecture of machine learning models for the label‐free identification of subtypes of ovarian cancer. The employment of a priori clinical information improves the classification performance, thus emulating the clinical application of liquid biopsy during ...
Daniele Pirone, Beatrice Cavina, Daniele Gaetano Sirico, Martina Mugnano, Vittorio Bianco, Lisa Miccio, Anna Myriam Perrone, Anna Maria Porcelli, Giuseppe Gasparre, Ivana Kurelac, Pasquale Memmolo, Pietro Ferraro   +11 more
wiley   +1 more source

Developing a strain‐dependent susceptibility to hepatocellular carcinoma in a murine model based on histopathological evidence and genetic context

Animal Models and Experimental Medicine, EarlyView.
Using F1 (C57BL/6J/Smad4+/− X CC) mice, we found that partial loss of Smad4 promotes liver carcinogenesis in a strain‐dependent manner, highlighting the importance of genetic modifiers in tumor susceptibility. The use of Collaborative Cross mice provides a valuable platform for uncovering genotype‐specific cancer susceptibilities in preclinical ...
Osayd Zohud, Aysar Nashef, Imad Abu‐Elnaaj, Fuad A. Iraqi   +3 more
wiley   +1 more source