Results 81 to 90 of about 542,674 (361)

CircRNA0052011 modulates DNA damage and repair via FEN1 ubiquitination to mitigate polystyrene nanoplastics-induced genotoxicity in the lung

Environment International
Polystyrene nanoplastics (PS-NPs) are one type of environmental pollutants that can penetrate biological barriers and accumulate within cells due to their small particle size. This characteristic raises concerns about their potential respiratory toxicity.
Meiqi Lan, Chenghui Zhong, Xiaole Xu, Mengnan He, Lieyang Fan, Wenfeng Lu, Liqiu Qiu, Jingwen Fang, Jiajing Wang, Shaojuan Wang, Zhizun Deng, Yingxin Chen, Lan Qiu, Xinyu Chen, Yiguo Jiang, Yun Zhou   +15 more
doaj   +1 more source

Comparison of the somatic mutations between circulating tumor DNA and tissue DNA in Chinese patients with non-small cell lung cancer

The International Journal of Biological Markers, 2022
Background Non-invasive liquid biopsies of circulating tumor DNA (ctDNA) is a rapidly growing field in the research of non-small cell lung cancer (NSCLC).
Meng Zhang, Yi Feng, Changda Qu, Meizhu Meng, Wenmei Li, Meiying Ye, Sisi Li, Shaolei Li, Yuanyuan Ma, Nan Wu, Shuqin Jia   +10 more
doaj   +1 more source

Insulin Injections Promote the Growth of Aberrant Crypt Foci in the Colon of Rats [PDF]

, 1997
The main objective of the present study was to test the hypothesis that exogenous insulin would enhance colon carcinogenesis. Thirty-six female F344 rats, fed ad libitum a low fat rodent chow, received a single azoxymethane injection (20 mg/kg), and were
Corpet, Denis E., Jacquinet, Claire, Peiffer, Ginette, Taché, Sylviane   +3 more
core   +1 more source

Fos co-operation with PTEN loss elicits keratoacanthoma not carcinoma due to p53/p21^WAF-induced differentiation triggered by GSK3b inactivation and reduced AKT activity [PDF]

, 2008
To investigate gene synergism in multistage skin carcinogenesis, the RU486-inducible cre/lox system was employed to ablate PTEN function [K14.cre/D5PTENflx] in mouse epidermis expressing activated v-fos [HK1.fos].
Alexander, C.L., Chan, W-C., Greenhalgh, D.A., Quinn, J., Wu, H., Yao, D.   +5 more
core   +1 more source

The Gut Microbiota Metabolite Urolithin B Prevents Colorectal Carcinogenesis by Remodeling Microbiota and PD-L1/HLA-B [PDF]

, 2023
Lixue Wang, Jinlong Chen, Qijun Chen, Hui Song, Ziqian Wang, Xing Wen, Siyao Jin, Xueying Song, Hua Yang, Wenhua Zhao   +9 more
openalex   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system. [PDF]

, 2003
The Apc(Min/+) mouse model and the azoxymethane (AOM) rat model are the main animal models used to study the effect of dietary agents on colorectal cancer. We reviewed recently the potency of chemopreventive agents in the AOM rat model (D. E.
Corpet, Denis E., Pierre, Fabrice
core   +2 more sources

Inflammation, DNA-centered radicals, and oxidative genotoxicity: The role of HOCl produced by myeloperoxidase in carcinogenesis [PDF]

, 2009
Myeloid cells (macrophages and neutrophils) infiltrate and synthesize myeloperoxidase (MPO) in sites of inflammation, producing gentotoxicity. In RAW 264.7 macrophages, bacterial lipopolysaccharide (LPS) induces superoxide radical anion, nuclear ...
Dario C. Ramirez, Sandra E. Gomez-Mejiba, Zili Zhai   +2 more
core   +2 more sources

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens

Nature Communications, 2019
Tiling-sgRNA designs allow the in situ evaluation of protein domain functions. Here the authors present ProTiler - a computational method to predict CRISPR knockout hyper-sensitive regions, revealing previously unannotated domains.
Wei He, Liang Zhang, Oscar D. Villarreal, Rongjie Fu, Ella Bedford, Jingzhuang Dou, Anish Y. Patel, Mark T. Bedford, Xiaobing Shi, Taiping Chen, Blaine Bartholomew, Han Xu   +11 more
doaj   +1 more source