Results 61 to 70 of about 280,367 (274)
Advanced Science, EarlyView.Identifying biomarkers associated with PTC, particularly those related to PTMC progression, is crucial for precise risk stratification and treatment planning. This study utilized single‐cell RNA sequencing on 19 surgical tissue specimens, confirmed PROS1/MERTK axis as a critical component of the cellular microenvironment and a key regulatory mechanism ...
Wenqian Zhang +11 more
wiley +1 more source
SPINDOC binds PARP1 to facilitate PARylation
Nature Communications, 2021 SPINDOC is known to interact with Spindlin1 (SPIN1), a histone code effector protein. Here, the authors show that SPINDOC is distributed between two distinct protein complexes, one comprising SPIN1 and the other one with PARP1.
Fen Yang +8 more
doaj +1 more source
Advanced Science, EarlyView.The bottom‐up strategy based on multiomics data is used for the SynCom design, and it successfully inhibited F. nucleatum growth and achieved stable colonization in vivo. In addition, it promoted tryptophan metabolism and secondary bile acid conversion, reduced lipid accumulation, relieved microbiome disorder, decreased inflammatory reaction, and ...
Zhongkun Zhou +11 more
wiley +1 more source
Does telomere elongation in cloned organisms lead to a longer lifespan if cancer is considered ? [PDF]
arXiv, 2004 ... By additionally considering a two-mutation model for carcinogenesis and indefinite proliferation by the activation of telomerase, we demonstrate that the risk of dying doe to cancer can outweigh the positive effect of longer telomeres on the longevity.
arxiv
Advanced Science, EarlyView.Based on IP‐MS analysis, BAG2 is confirmed to be essential for ubiquitination and protein homeostasis regulation of STING in cervical cancer. BAG2 inhibits the ubiquitination and degradation of STING by forming a complex with STUB1, thereby activating the type I IFN signaling pathway and inhibiting the development of cervical cancer.
Shijie Yao +6 more
wiley +1 more source
Environment International, 2020 Fine particulate matter (PM2.5) has been verified to augmented the incidence of pneumonia, asthma, pulmonary fibrosis, and other pulmonary diseases. Airway inflammation is the pathological basis of the respiratory system, and understanding the molecular ...
Yangyang Jia +10 more
doaj
De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens
Nature Communications, 2019 Tiling-sgRNA designs allow the in situ evaluation of protein domain functions. Here the authors present ProTiler - a computational method to predict CRISPR knockout hyper-sensitive regions, revealing previously unannotated domains.
Wei He +11 more
doaj +1 more source
Telomere loss limits the rate of human epithelial tumor formation [PDF]
arXiv, 2005 Most human carcinomas exhibit telomere abnormalities early in the carcinogenesis process suggesting that crisis caused by telomere shortening may be a necessary event leading to human carcinomas. Epidemiological records of the age at which each patient in a population develops carcinoma are known as age-incidence data; these provide a quantitative ...
arxiv
Advanced Science, EarlyView.The study identifies a novel circular RNA derived from the TP53 gene (circTP53), which is upregulated in HNSCC and correlates with poor patient prognosis. It demonstrates that circTP53 promotes HNSCC progression by interacting with USP10, stabilizing both proteins, enhancing deubiquitination of p53, and thereby influencing tumor growth, with its ...
Yin Wang +11 more
wiley +1 more source
A Theoretical Model of Chaotic Attractor in Tumor Growth and Metastasis [PDF]
arXiv, 2008 This paper proposes a novel chaotic reaction-diffusion model of cellular tumor growth and metastasis. The model is based on the multiscale diffusion cancer-invasion model (MDCM) and formulated by introducing strong nonlinear coupling into the MDCM. The new model exhibits temporal chaotic behavior (which resembles the classical Lorenz strange attractor)
arxiv