Results 211 to 220 of about 113,709 (339)

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Pentoxazone (Second Edition) (Pesticides). [PDF]

Food Saf (Tokyo)
Food Safety Commission of Japan.
europepmc   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Why rat oral cavity tumors should not be the basis of quantitative cancer risk assessment for oral exposure to hexavalent chromium. [PDF]

Toxicol Sci
Proctor D, Jiang X, Reichert H, Thompson C.   +3 more
europepmc   +1 more source

Locating High Affinity Binding Sites of the Carcinogen 4-Nitroquinoline-1-Oxide on PhiX174 DNA Using Restriction Enzyme Activity Assays

, 2016
Jessie Limonta
openalex   +1 more source

Lung carcinogenicity by whole body inhalation exposure to Anatase-type Nano-titanium Dioxide in rats

Tatsuya Kasai, Shigeyuki Hirai, Yuske Furukawa, Kyouhei Misumi, Tomoki Takeda, Yuko Goto‐Koshino, Kenji Takanobu, Kengo Yoneyama, Shotaro Yamano, Hideki Senoh, Yumi Umeda   +10 more
openalex   +2 more sources

(Study of the mechanism of carcinogenesis by carcinogens which are negative in the Ames test). Progress report, December 1, 1977--April 1, 1978. [Hormone metabolism, rats, chickens]

, 1978
Ernest Borek
openalex   +2 more sources

Evaluation of the standard battery of in vitro genotoxicity tests to predict in vivo genotoxicity through mathematical modeling: A report from the 8th International Workshop on Genotoxicity Testing

Environmental and Molecular Mutagenesis, EarlyView.
Abstract In human health risk assessment of chemicals and pharmaceuticals, identification of genotoxicity hazard usually starts with a standard battery of in vitro genotoxicity tests, which is needed to cover all genotoxicity endpoints. The individual tests included in the battery are not designed to pick up all endpoints.
Mirjam Luijten, Jan van Benthem, Takeshi Morita, Raffaella Corvi, Patricia A. Escobar, Yurika Fujita, Jennifer Hemmerich, Naveed Honarvar, David Kirkland, Naoki Koyama, David P. Lovell, Miriam Mathea, Andrew Williams, Stephen Dertinger, Stefan Pfuhler, Jeroen L. A. Pennings   +15 more
wiley   +1 more source

Oncotransformation in Bhas 42 Cell Transformation Assay by Typical Non-Genotoxic Carcinogens, PFOA and PFOS, and Time-Course Transcriptome Analysis. [PDF]

Biomolecules
Ohmori K.
europepmc   +1 more source

Carcinogenicity Prediction of Schiff Base Ligand in Male Mice

, 2019
Kamel Mokhnache, Soraya Madoui, Noureddine Charef   +2 more
openalex   +1 more source