Results 11 to 20 of about 34,758 (354)

DNA adducts as link between in vitro and in vivo carcinogenicity – A case study with benzo[a]pyrene

Current Research in Toxicology, 2023
To reduce the need for animal tests, in vitro assays are often used as alternative methods. To derive toxic doses for higher tier organisms from in vitro assay results, quantitative in vitro-in vivo extrapolation (qIVIVE) based on physiological-based ...
Martin Gerhards, Alexander Böhme, Kristin Schubert, Bernhard Kodritsch, Nadin Ulrich   +4 more
doaj   +1 more source

Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS/JEMS

Genes and Environment, 2021
Background Conflicting results between bacterial mutagenicity tests (the Ames test) and mammalian carcinogenicity tests might be due to species differences in metabolism, genome structure, and DNA repair systems. Mutagenicity assays using human cells are
Manabu Yasui, Takayuki Fukuda, Akiko Ukai, Jiro Maniwa, Tadashi Imamura, Tsuneo Hashizume, Haruna Yamamoto, Kaori Shibuya, Kazunori Narumi, Yohei Fujiishi, Emiko Okada, Saori Fujishima, Mika Yamamoto, Naoko Otani, Maki Nakamura, Ryoichi Nishimura, Maya Ueda, Masayuki Mishima, Kaori Matsuzaki, Akira Takeiri, Kenji Tanaka, Yuki Okada, Munehiro Nakagawa, Shuichi Hamada, Akihiko Kajikawa, Hiroshi Honda, Jun Adachi, Kentaro Misaki, Kumiko Ogawa, Masamitsu Honma   +29 more
doaj   +1 more source

TESTS FOR CARCINOGENICITY OF ASBESTOS* [PDF]

Annals of the New York Academy of Sciences, 1965
W E, Smith, L, Miller, R E, Elsasser, D D, Hubert   +3 more
openaire   +3 more sources

Carcinogenicity and testicular toxicity of 2-bromopropane in a 26-week inhalation study using the rasH2 mouse model

Scientific Reports, 2023
2-Bromopropane (2-BP) is a colorless liquid at room temperature and is used in closed systems in factories, mainly as an intermediate for medicines, pesticides, and other chemicals. However, the carcinogenicity of 2-BP is still unknown.
Yuko Goto, Arata Saito, Kenji Takanobu, Hideki Senoh, Misae Saito, Yumi Umeda, Shotaro Yamano   +6 more
doaj   +1 more source

Bacterial Reverse Mutation Test of Verbenalin

Journal of Pharmacopuncture, 2022
Objectives: Verbenalin is a compound found in herbs such as Cornus officinalis and Verbena officinalis. This study investigated whether verbenalin is safe by analyzing its mutagenicity.
Hye Jeong Shin, Yi Gun Lim, Ji Su Ha, Gabsik Yang, Tae Han Yook   +4 more
doaj   +1 more source

A Novel Strategy to Predict Carcinogenicity of Antiparasitics Based on a Combination of DNA Lesions and Bacterial Mutagenicity Tests

Frontiers in Public Health, 2017
Genotoxicity and carcinogenicity testing of pharmaceuticals prior to commercialization is requested by regulatory agencies. The bacterial mutagenicity test was considered having the highest accuracy of carcinogenic prediction.
Qianying Liu, Zhixin Lei, Feng Zhu, Awais Ihsan, Xu Wang, Zonghui Yuan, Zonghui Yuan, Zonghui Yuan   +7 more
doaj   +1 more source

A comparison of the results from intra-pleural and intra-peritoneal studies with those from inhalation and intratracheal tests for the assessment of pulmonary responses to inhalable dusts and fibres. [PDF]

, 2016
The aim of this paper is to compare results from inhalation studies with those from intraperitoneal and intrapleural tests, where available, for a number of fibrous and particulate test materials.
Bevan, Ruth, Drummond, Gail, Harrison, Paul   +2 more
core   +2 more sources

A comprehensive analysis of the animal carcinogenicity data for glyphosate from chronic exposure rodent carcinogenicity studies

Environmental Health, 2020
Since the introduction of glyphosate-tolerant genetically-modified plants, the global use of glyphosate has increased dramatically making it the most widely used pesticide on the planet. There is considerable controversy concerning the carcinogenicity of
Christopher J. Portier
doaj   +1 more source

Low doses of ochratoxin A induce micronucleus formation and delay DNA repair in human lymphocytes [PDF]

, 2014
The contamination of food commodities by fungal toxins has attracted great interest because many of these mycotoxins are responsible for different diseases, including cancer and other chronic illnesses. Ochratoxin A (OTA) is a mycotoxin naturally present
Barrón-Vivanco, Briscia S., Benitez-Trinidad, alma B., González Arias, Cyndia A., Marín Sillué, Sònia, Medina-Díaz, Irma M., Ramos Girona, Antonio J., Robledo-Marenco, Lourdes, Rojas-García, A. E., Sanchís Almenar, Vicente, Sordo, Montserrat   +9 more
core   +2 more sources

The Assessment of the Biocompatibility of Dental Alloys and Alloys for Dental Amalgam. Part Second

Česká Stomatologie a Praktické Zubní Lékařství, 2014
Background: The second part of the literature review on the biocompatibility of dental alloys is focused to their possible sensibilizing effects, mutagenicity and carcinogenicity and the methods of their testing.
Z. Broukal, V. Fialová, J. Novotný
doaj   +1 more source