Results 11 to 20 of about 34,330 (305)

New Short Term Prediction Method for Chemical Carcinogenicity by Hepatic Transcript Profiling following 28-Day Toxicity Tests in Rats

open access: yesCancer Informatics, 2011
We have previously shown the hepatic gene expression profiles of carcinogens in 28-day toxicity tests were clustered into three major groups (Group-1 to 3).
Hiroshi Matsumoto   +9 more
doaj   +2 more sources

Carcinogenicity and testicular toxicity of 2-bromopropane in a 26-week inhalation study using the rasH2 mouse model

open access: yesScientific Reports, 2023
2-Bromopropane (2-BP) is a colorless liquid at room temperature and is used in closed systems in factories, mainly as an intermediate for medicines, pesticides, and other chemicals. However, the carcinogenicity of 2-BP is still unknown.
Yuko Goto   +6 more
doaj   +1 more source

Bacterial Reverse Mutation Test of Verbenalin

open access: yesJournal of Pharmacopuncture, 2022
Objectives: Verbenalin is a compound found in herbs such as Cornus officinalis and Verbena officinalis. This study investigated whether verbenalin is safe by analyzing its mutagenicity.
Hye Jeong Shin   +4 more
doaj   +1 more source

A Novel Strategy to Predict Carcinogenicity of Antiparasitics Based on a Combination of DNA Lesions and Bacterial Mutagenicity Tests

open access: yesFrontiers in Public Health, 2017
Genotoxicity and carcinogenicity testing of pharmaceuticals prior to commercialization is requested by regulatory agencies. The bacterial mutagenicity test was considered having the highest accuracy of carcinogenic prediction.
Qianying Liu   +7 more
doaj   +1 more source

A comparison of the results from intra-pleural and intra-peritoneal studies with those from inhalation and intratracheal tests for the assessment of pulmonary responses to inhalable dusts and fibres. [PDF]

open access: yes, 2016
The aim of this paper is to compare results from inhalation studies with those from intraperitoneal and intrapleural tests, where available, for a number of fibrous and particulate test materials.
Bevan, Ruth   +2 more
core   +2 more sources

A comprehensive analysis of the animal carcinogenicity data for glyphosate from chronic exposure rodent carcinogenicity studies

open access: yesEnvironmental Health, 2020
Since the introduction of glyphosate-tolerant genetically-modified plants, the global use of glyphosate has increased dramatically making it the most widely used pesticide on the planet. There is considerable controversy concerning the carcinogenicity of
Christopher J. Portier
doaj   +1 more source

Low doses of ochratoxin A induce micronucleus formation and delay DNA repair in human lymphocytes [PDF]

open access: yes, 2014
The contamination of food commodities by fungal toxins has attracted great interest because many of these mycotoxins are responsible for different diseases, including cancer and other chronic illnesses. Ochratoxin A (OTA) is a mycotoxin naturally present
Barrón-Vivanco, Briscia S.   +9 more
core   +2 more sources

The Assessment of the Biocompatibility of Dental Alloys and Alloys for Dental Amalgam. Part Second

open access: yesČeská Stomatologie a Praktické Zubní Lékařství, 2014
Background: The second part of the literature review on the biocompatibility of dental alloys is focused to their possible sensibilizing effects, mutagenicity and carcinogenicity and the methods of their testing.
Z. Broukal, V. Fialová, J. Novotný
doaj   +1 more source

Safety assessment of the substance phosphorous acid, mixed 2,4-bis(1,1-dimethylpropyl)phenyl and 4-(1,1-dimethylpropyl)phenyl triesters for use in food contact materials [PDF]

open access: yes, 2017
Publisher ...
Barthélémy, Eric   +24 more
core   +3 more sources

Permitted daily exposure for diisopropyl ether as a residual solvent in pharmaceuticals [PDF]

open access: yes, 2018
Solvents can be used in the manufacture of medicinal products provided their residual levels in the final product comply with the acceptable limits based on safety data.
Evandri, Maria Grazia, Romanelli, Luca
core   +1 more source

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