Results 41 to 50 of about 33,845 (314)

Ochratoxin A: In Utero Exposure in Mice Induces Adducts in Testicular DNA [PDF]

, 2010
Ochratoxin A (OTA) is a nephrotoxin and carcinogen that is associated with Balkan endemic nephropathy and urinary tract tumors. OTA crosses the placenta and causes adducts in the liver and kidney DNA of newborns.
Jamie E. Jennings-Gee, Mariana Tozlovanu, Richard Manderville, Mark Steven Miller, Annie Pfohl-Leszkowicz, Gary G. Schwartz, O’Brien, Pfohl-Leszkowicz, Reddy, Krogh, Stoev, Chernozemsky, Pfohl-Leszkowicz, Castegnaro, Huyghe, Schwartz, Ueta, Raymond, Mantle, Mantle, Pfohl-Leszkowicz, Petkova-Bocharova, Petkova-Bocharova, Satoh, Manderville, Faucet, Gillman, Molinié, Nguyen, Petkova-Bocharova, Faucet-Marquis, Frenette, Pfohl-Leszkowicz, Mantle, Pfohl-Leszkowicz, Pinelli, El Adlouni, Petkova-Bocharova, Pfohl-Leszkowicz, Verma, Kamataki, Gustafsson, Atanasova, Pfohl-Leszkowicz, Pfohl-Leszkowicz, Pfohl-Leszkowicz, Dimitrov, Møller, Bay, Bose, Solti, Patil, Lei   +52 more
core   +3 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

In vivo mutagenicity assessment of orally treated tert-butyl hydroperoxide in the liver and glandular stomach of MutaMouse

Genes and Environment, 2023
Background tert-Butyl hydroperoxide (TBHP; CAS 75–91-2), a hydroperoxide, is mainly used as a polymerization initiator to produce polyethylene, polyvinyl chloride, and unsaturated polyester.
Yasumasa Murata, Kenichiro Suzuki, Yoshiyuki Shigeta, Takako Iso, Nozomu Hirose, Takaaki Umano, Katsuyoshi Horibata, Kei-ichi Sugiyama, Akihiko Hirose, Kenichi Masumura, Mariko Matsumoto   +10 more
doaj   +1 more source

Novel Tailoring of Ternary ZnS‐MXene‐TiO2 Nanocomposite Heterojunction and Its Tunable Electrochemical Properties With Enhanced Photocatalytic Degradation

Advanced Engineering Materials, EarlyView.
ZnS‐MXene‐TiO2 nanocomposite heterojunction for photocatalytic decomposition of this methylene blue dye (MB) greatly improves light absorption, charge separation, and active site area. Two‐dimensional MXene forms nanocomposites by easily combining them with 0D (quantum dots), 1D (tube and wire), 2D (plane and sheet), and 3D (particle and lamellar ...
Latiful Kabir, Dohyun Kim, Minho Song, Jae Doc Na, Young Jun Joo, Kwang Youn Cho, Karna Wijaya, Won‐Chun Oh   +7 more
wiley   +1 more source

Cellular Immune Response Induced by DNA Immunization of Mice with Drug Resistant Integrases of HIV-1 Clade A Offers Partial Protection against Growth and Metastatic Activity of Integrase-Expressing Adenocarcinoma Cells

Microorganisms, 2021
Therapeutic DNA-vaccination against drug-resistant HIV-1 may hinder emergence and spread of drug-resistant HIV-1, allowing for longer successful antiretroviral treatment (ART) up-to relief of ART.
Maria Isaguliants, Olga Krotova, Stefan Petkov, Juris Jansons, Ekaterina Bayurova, Dzeina Mezale, Ilze Fridrihsone, Athina Kilpelainen, Philip Podschwadt, Yulia Agapkina, Olga Smirnova, Linda Kostic, Mina Saleem, Oleg Latyshev, Olesja Eliseeva, Anastasia Malkova, Tatiana Gorodnicheva, Britta Wahren, Ilya Gordeychuk, Elizaveta Starodubova, Anastasia Latanova   +20 more
doaj   +1 more source

Significant Subgraph Mining with Multiple Testing Correction [PDF]

, 2015
The problem of finding itemsets that are statistically significantly enriched in a class of transactions is complicated by the need to correct for multiple hypothesis testing.
Borgwardt, Karsten M., Kasenburg, Niklas, López, Felipe Llinares, Sugiyama, Mahito   +3 more
core   +1 more source

Direct Metal Deposition of Graphene–Ti28Nb35.4Zr Matrix Composites With Enhanced Mechanical, Corrosion, and Biocompatibility Properties for Bone Implants

Advanced Engineering Materials, EarlyView.
Graphene nanoplatelet (0.1 wt.%) reinforcement significantly enhances the performance of β Ti‐28Nb‐35.4Zr alloy. Grain refinement, reduced water contact angle, and improved surface characteristics promote osteoblast adhesion and complete surface coverage after 7 days.
Khurram Munir, Jixing Lin, Yuncang Li, Li Zhu, Paul F. A. Wright, Cuie Wen   +5 more
wiley   +1 more source

Characteristics of Medical Products Comprising Human Cells, Genes, or Tissues Developed in Japan and the European Union Compared via Public Assessment Reports

Frontiers in Bioengineering and Biotechnology, 2020
Medical products comprising human cells, genes, and tissues have been developed for clinical applications worldwide, and their developmental environment has been established.
Ryosuke Kurauchi, Ryosuke Kurauchi, Hiroi Kasai, Tatsuya Ito   +3 more
doaj   +1 more source

Developmental neurotoxicity induced by glutaraldehyde in neuron/astrocyte co-cultured cells and zebrafish

Ecotoxicology and Environmental Safety, 2022
The genotoxicity, development toxicity, carcinogenicity, and acute or chronic toxic effects of glutaraldehyde (GA), particularly during occupational exposure through its use as a fixative, disinfectant, and preservative, are well-documented but its ...
Ha-Na Oh, Donggon Yoo, Seungmin Park, Sangwoo Lee, Woo-Keun Kim   +4 more
doaj   +1 more source

An Ensemble Model of QSAR Tools for Regulatory Risk Assessment [PDF]

, 2016
Quantitative structure activity relationships (QSARs) are theoretical models that relate a quantitative measure of chemical structure to a physical property or a biological effect.
Merrill, Stephen, Povinelli, Richard J., Pradeep, Prachi, White, Shannon   +3 more
core   +4 more sources