Results 261 to 270 of about 2,980,265 (315)
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Carcinogenicity testing of drugs
1985The dramatic advances in medicine in the last fifty years have stemmed in large part from extensive research to discover new effective medications for controlling and treating many types of diseases that afflict mankind. In the development of new drugs, an increasingly important aspect is to predict and assess any adverse effects that the products ...
G M, Williams, J H, Weisburger
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Australasian Journal of Dermatology, 1969
Summary A carcinogen in the form of whole tobacco smoke condensate was applied to the skin of a group of human subjects most of whom had suffered from bronchogenic carcinoma. One week later the epidermal density was estimated on the area exposed to the carcinogen and compared with, the density of unexposed epidermis in the same subject.
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Summary A carcinogen in the form of whole tobacco smoke condensate was applied to the skin of a group of human subjects most of whom had suffered from bronchogenic carcinoma. One week later the epidermal density was estimated on the area exposed to the carcinogen and compared with, the density of unexposed epidermis in the same subject.
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The peritoneal cell carcinogenicity test
Mutation Research Letters, 1986The peritoneal cell carcinogenicity test, which is a new short-term in vivo-in vitro transformation test invented by Nashed (1981), was evaluated in the present report. The experimental design and materials used were as close as possible to those used by Nashed (1981).
Nielsen, Jesper B., Andersen, Ole
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2013
In vitro and short-term in vivo test systems for identifying chemicals with carcinogenic potential are described. Unlike other toxicity endpoints typically measured, cancer is the cumulative effect of a series of molecular, cellular, and tissue changes proceeding sequentially.
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In vitro and short-term in vivo test systems for identifying chemicals with carcinogenic potential are described. Unlike other toxicity endpoints typically measured, cancer is the cumulative effect of a series of molecular, cellular, and tissue changes proceeding sequentially.
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Carcinogen testing fact and fallacy
Cancer, 1988In the absence of human information on the carcinogenicity of chemical substances, one must rely primarily on information from long-term animal testing. Although far from perfect, animal studies seem to be reasonable predictors of the human experience, both qualitatively and quantitatively.
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1985
Epidemiological evidence strongly suggests that environmental factors are a major cause of cancer.1,2 Although some of these factors are self-imposed (e.g. cigarette smoking) there are many other unintentional routes of carcinogen uptake, such as the diet, and by exposure to both natural and synthetic chemicals present in our environment (e.g ...
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Epidemiological evidence strongly suggests that environmental factors are a major cause of cancer.1,2 Although some of these factors are self-imposed (e.g. cigarette smoking) there are many other unintentional routes of carcinogen uptake, such as the diet, and by exposure to both natural and synthetic chemicals present in our environment (e.g ...
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Bacterial systems for carcinogenicity testing
Mutation Research/Reviews in Genetic Toxicology, 1981During the past 30 years, bacterial test systems have been extensively refined in their ability to detect not only mutagenic agents but, in many cases, carcinogenic ones as well. Since many carcinogens are known to be activated within the mammalian body, major improvements in bacterial test systems were made when representative parts of mammalian ...
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Carcinogenicity Testing of Antitumor Agents
Toxicologic Pathology, 1985Carcinogenicity testing of antitumor agents in animal bioassays has been proposed because of the potential for carcinogenicity of this class of agents and the expectation that such testing may indicate prospectively the target organs of any related human oncogenesis. The literature reveals the anticipated confirmations in animals of the carcinogenicity
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Issues in Carcinogenicity Testing: Dose Selection
Toxicological Sciences, 1985Dose selection in testing chemicals for possible carcinogenicity in rodents continues to be an area of scientific debate. In this paper the definition of "maximum tolerated dose" (MTD) is considered, and the advantages and disadvantages of using MTDs are given.
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Carcinogen Testing & Public Information
The Hastings Center Report, 1980Editor's note: In August 1979, the Hastings Center Report published an article by Barry Bloom, "News about Carcinogens: What's Fit to Print?" In it, Professor Bloom raised many questions about the National Cancer Institute's policy of testing and publishing information on possible carcinogens.
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