Results 1 to 10 of about 36,995 (262)

A signature-agnostic test for differences between tumor mutation spectra reveals carcinogen and ancestry effects [PDF]

Communications Biology
Despite dozens of tools to identify mutational signatures in cancer samples, there is not an established metric for quantifying whether signature exposures differ significantly between two heterogeneous groups of samples.
Samuel F. M. Hart, Nicolas Alcala, Alison F. Feder, Kelley Harris   +3 more
doaj   +2 more sources

Environmental carcinogens often exacerbate endogenous mutagenic processes to enhance tumor promotion [PDF]

Cell Reports
Summary: Environmental exposures significantly influence cancer risk, but their mutational impact remains unclear. We perform whole-exome sequencing of hepatocellular carcinomas (HCCs) from B6C3F1/N mice that arise spontaneously with age (2 years old) or
Miaofei Xu, Jianying Li, Yun-Chung Hsiao, Ramesh C. Kovi, Jian-Liang Li, Leszek J. Klimczak, Laura Riva, David Adams, Pierre R. Bushel, B. Alex Merrick, Dmitry Gordenin, John R. Bucher, Robert C. Sills, Arun R. Pandiri   +13 more
doaj   +2 more sources

Paving the Way to Elucidate Hg's Role in Tumorigenesis [PDF]

Advanced Science
Tumorigenesis can be induced by diverse environmental carcinogens, with mercury (Hg)—a global pollutant that accumulates in humans throughout life, crosses the blood‐brain and placental barriers, and is poorly excreted—classified as a Group 2B carcinogen;
Shouying Li, Rong Zhong, Zhenyang Yu, Hualing Fu, Jin Chen, Jia Wei, Ningwei Zhao, Le Qu, Tiantian Li, Wenli Tang, Huan Zhong   +10 more
doaj   +2 more sources

Chemopreventive roles of medicinal foods against environmental carcinogens-induced cancers [PDF]

World Cancer Research Journal, 2021
Objective: Cancer remains the major cause of death globally apart from cardiovascular diseases. Behavioural and dietary risks could trigger up to 70% of new cancer cases in the next 20 years based on speculations.
J. Teibo, O. Akinfe, A. Olagunju, F. Olorunfemi, T. Teibo, O. Olaoba, K. Ayinde, A. Babalola   +7 more
doaj   +1 more source

Release of PAH from Secondary Products Made from End-of-Life Tire Recyclates into 20% Aqueous Ethanol as Assessment of Human Dermal Absorption

Recycling, 2022
Compliance with the legal limits set at the European level for the content of polycyclic aromatic hydrocarbons (PAH), which are harmful to human health and the environment, is of central importance for the recycling of rubber, particularly end-of-life ...
Stefan Hoyer, Lothar Kroll, Benny Fischer, Kai Pisulla, Albrecht Seidel   +4 more
doaj   +1 more source

A tiered approach to prioritizing registered pesticides for potential cancer hazard evaluations: implications for decision making

Environmental Health, 2021
Background Over 800 pesticides are registered for use in the United States. Human studies indicate concern that some pesticides currently in use in large quantities may also pose a carcinogenic hazard.
Pamela J. Schwingl, Ruth M. Lunn, Suril S. Mehta   +2 more
doaj   +1 more source

Environmental carcinogens disproportionally mutate genes implicated in neurodevelopmental disorders

Frontiers in Neuroscience, 2023
IntroductionDe novo mutations contribute to a large proportion of sporadic psychiatric and developmental disorders, yet the potential role of environmental carcinogens as drivers of causal de novo mutations in neurodevelopmental disorders is poorly ...
Brennan H. Baker, Shaoyi Zhang, Jeremy M. Simon, Sarah M. McLarnan, Wendy K. Chung, Brandon L. Pearson   +5 more
doaj   +1 more source

An approach to estimating the environmental burden of cancer from known and probable carcinogens: application to Ontario, Canada

BMC Public Health, 2020
Background Quantifying the potential cancer cases associated with environmental carcinogen exposure can help inform efforts to improve population health.
Susan Lavinia Greco, Elaina MacIntyre, Stephanie Young, Hunter Warden, Christopher Drudge, JinHee Kim, Elisa Candido, Paul Demers, Ray Copes   +8 more
doaj   +1 more source

Predictors of Multiple Primary Malignancies: Literature Review

Креативная хирургия и онкология, 2023
The present paper considers the predictors of multiple primary malignancies. The multiple primary malignancies are often induced by genetic predisposition and familial cancer syndromes, environmental carcinogens and bad habits (e.g.
A. V. Sultanbaev, K. V. Menshikov, Sh. I. Musin, A. A. Izmailov, I. A. Menshikova, N. I. Sultanbaeva   +5 more
doaj   +1 more source

The Mutagenic Impact of Environmental Exposures in Human Cells and Cancer: Imprints Through Time

Frontiers in Genetics, 2021
During life, the DNA of our cells is continuously exposed to external damaging processes. Despite the activity of various repair mechanisms, DNA damage eventually results in the accumulation of mutations in the genomes of our cells.
Axel Rosendahl Huber, Axel Rosendahl Huber, Arne Van Hoeck, Arne Van Hoeck, Ruben Van Boxtel, Ruben Van Boxtel   +5 more
doaj   +1 more source