Results 31 to 40 of about 3,679,735 (330)

The mutational signature profile of known and suspected human carcinogens in mice

Nature Genetics, 2020
Epidemiological studies have identified many environmental agents that appear to significantly increase cancer risk in human populations. By analyzing tumor genomes from mice chronically exposed to 1 of 20 known or suspected human carcinogens, we reveal ...
L. Riva, A. Pandiri, Y. R. Li, A. Droop, J. Hewinson, M. Quail, V. Iyer, Rebecca Shepherd, R. Herbert, P. Campbell, R. Sills, L. Alexandrov, A. Balmain, D. Adams   +13 more
semanticscholar   +1 more source

A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells [PDF]

, 2017
Human exposure to carcinogens occurs via a plethora of environmental sources, with 70–90% of cancers caused by extrinsic factors. Aberrant phenotypes induced by such carcinogenic agents may provide universal biomarkers for cancer causation.
A Mitchell, AL Seager, Ann T. Doherty, Anna L. Seager, AR Molina de, C Casals-Casas, C Fumarola, D Avancini, D Breheny, D Gusenleitner, D Hanahan, D Hanahan, D Kirkland, D Kirkland, DJ Dix, DM Reif, DM Reif, DT Beranek, E Niki, E Willems, Eleanor C. Wilde, F Caiment, F Lang, G Robinson, GA Kerckaert, Gareth J. S. Jenkins, George E. Johnson, GM Williams, H Bartsch, I Rusyn, J Hukkanen, J Lukas, J McKim, J Sampson, James A. Tonkin, Jatin R. Verma, JC Caldwell, JH Tsai, JY Kim, K Brusehafer, K-H Kim, K-J Kwon, Katherine E. Chapman, Katja Brüsehafer, KW Bock, KZ Guyton, L Muller, L Stannard, Leanne M. Stannard, LF Stankowski, LG Hernandez, M Fenech, M Finnegan, M Kirsch-Volders, M. Rowan Brown, ME Long, MT Smith, NC Kleinstreuer, NR Council, NW Biggart, PC Chan, PJ Brooks, PK Mandal, Q Ke, R Benigni, R Herwig, RL Melnick, S Banin, S Grünert, S Knerr, S Llanos, S Wu, SC Tilton, SH Doak, Shareen H. Doak, SK Chakrabarti, T Bourcier, T Kruger, T Uehara, U Pinkernell, Ume-Kulsoom Shah, V Thybaud, W Lijinsky, Y Adeleye, Y Ioannou, Z Pincus   +85 more
core   +1 more source

The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis.

Carcinogenesis, 2015
The purpose of this review is to stimulate new ideas regarding low-dose environmental mixtures and carcinogens and their potential to promote invasion and metastasis.
J. Ochieng, G. Nangami, Olugbemiga Ogunkua, I. Miousse, Igor Koturbash, V. Odero-Marah, L. Mccawley, P. Nangia-Makker, N. Ahmed, Y. Luqmani, Zhenbang Chen, S. Papagerakis, Gregory T Wolf, Chenfang Dong, Binhua P. Zhou, Dustin G. Brown, A. Colacci, R. A. Hamid, C. Mondello, Jayadev Raju, E. Ryan, Jordan Woodrick, A. Scovassi, Neetu Singh, M. Vaccari, R. Roy, S. Forte, L. Memeo, H. Salem, A. Amedei, R. Al-Temaimi, F. Al-Mulla, William H. Bisson, Sakina E. Eltom   +33 more
semanticscholar   +1 more source

Nonmutagenic carcinogens induce intrachromosomal recombination in dividing yeast cells. [PDF]

, 1993
A large number of animal and human carcinogens without apparent genotoxic activity exist (nonmutagenic carcinogens) that are difficult or impossible to detect with the currently used short-term tests.
Schiestl, RH
core   +2 more sources

Unraveling Therapeutic Opportunities and the Diagnostic Potential of microRNAs for Human Lung Cancer

Pharmaceutics, 2023
Lung cancer is a major public health problem and a leading cause of cancer-related deaths worldwide. Despite advances in treatment options, the five-year survival rate for lung cancer patients remains low, emphasizing the urgent need for innovative ...
Osama Sweef, Elsayed Zaabout, Ahmed Bakheet, Mohamed Halawa, Ibrahim Gad, Mohamed Akela, Ehab Tousson, Ashraf Abdelghany, Saori Furuta   +8 more
doaj   +1 more source

Preventing hereditary cancers caused by opportunistic carcinogens [PDF]

, 2011
Objectives Previous studies reported inherited BRCA1/2 deficits appear to cause cancer by impairing normal protective responses to some carcinogens.
Bernard Friedenson
core   +2 more sources

Triple primary lung cancer: a case report

BMC Pulmonary Medicine, 2022
Background The risk of developing lung cancer is increased in smokers, patients with chronic obstructive pulmonary disease, individuals exposed to environmental carcinogens, and those with a history of lung cancer.
Hye Sook Choi, Ji-Youn Sung
doaj   +1 more source

Identifying occupational carcinogens: an update from the IARC Monographs

Occupational and Environmental Medicine, 2018
The recognition of occupational carcinogens is important for primary prevention, compensation and surveillance of exposed workers, as well as identifying causes of cancer in the general population.
D. Loomis, N. Guha, A. Hall, K. Straif
semanticscholar   +1 more source

Co-carcinogenesis: Human Papillomaviruses, Coal Tar Derivatives, and Squamous Cell Cervical Cancer

Frontiers in Microbiology, 2017
Cervical cancer (CC) is the fourth most common cancers among women worldwide. Human papillomaviruses (HPVs) play a major role in the etiology of CC, with several lines of epidemiologic and experimental evidence supporting a role for non-viral (co ...
Harry W. Haverkos, Gregory P. Haverkos, Michael O’Mara   +2 more
doaj   +1 more source

Changes in miR-124-1, miR-212, miR-132, miR-134, and miR-155 Expression Patterns after 7,12-Dimethylbenz(a)anthracene Treatment in CBA/Ca Mice

Cells, 2022
Specific gene and miRNA expression patterns are potential early biomarkers of harmful environmental carcinogen exposures. The aim of our research was to develop an assay panel by using several miRNAs for the rapid screening of potential carcinogens.
Andras Tomesz, Laszlo Szabo, Richard Molnar, Arpad Deutsch, Richard Darago, Bence L. Raposa, Nowrasteh Ghodratollah, Timea Varjas, Balazs Nemeth, Zsuzsanna Orsos, Eva Pozsgai, Jozsef L. Szentpeteri, Ferenc Budan, Istvan Kiss   +13 more
doaj   +1 more source