Results 241 to 250 of about 372,123 (339)

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl, J. Christopher Corton, Henghong Li, Jiri Aubrecht, Scott S. Auerbach, Florian Caiment, Tatyana Y. Doktorova, Yurika Fujita, Danyel Jennen, Naoki Koyama, Matthew J. Meier, Roman Mezencev, Leslie Recio, Takayoshi Suzuki, Carole L. Yauk   +14 more
wiley   +1 more source

A Review of the Most Frequent Compounds, Metals, and Compound and Metal Mixtures Found at U.S. Superfund Sites and Their Carcinogenic Potential. [PDF]

Chem Res Toxicol
Dunnick JK, Schmitt CP, Dixon D.
europepmc   +1 more source

Mechanistic studies on the molecular toxicology of the carcinogen PhIP: the role of microRNAs

, 2016
Michail-Dimitrios Papaioannou
openalex   +2 more sources

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li, Jiri Aubrecht, Tatyana Y. Doktorova, Danyel Jennen, J. Christopher Corton, Roland Froetschl, Roman Mezencev, Carole L. Yauk   +7 more
wiley   +1 more source

Carcinogenicity of vinyl acetate: evidence from multiple data streams. [PDF]

Environ Health
Li K, Ricker K, Tsai FC, Cheng V, Osborne G, Guha N, Elmore S, Alvarado-Cruz I, Sandy MS, Sun M.   +9 more
europepmc   +1 more source

Sustainable polypropylene chair: A life cycle assessment and cost analysis of industrial production

Environmental Progress &Sustainable Energy, EarlyView.
Abstract Due to their multiple properties, including flexibility, lightness, and strength, thermoplastics are an essential material in the development of processes at both industrial and domestic levels. However, thermoplastics are often derived from polymers synthesized using non‐renewable petroleum resources. This has environmental consequences.
Lucrezia Maggi, Alberto Pietro Damiano Baltrocchi, Marco Carnevale Miino, Elena Cristina Rada, Vincenzo Torretta   +4 more
wiley   +1 more source

Molecular mechanisms of air pollution-induced carcinogenesis and the emerging role of microplastics. [PDF]

Hum Genomics
Vu J, Nadeau K, Kasowski M.
europepmc   +1 more source

Supplementary Fig 2 from Ubiquitin ligases Siah1a/2 control alveolar macrophage functions to limit carcinogen-induced lung adenocarcinoma

Marzia Scortegagna, Yuanning Du, Linda M. Bradley, Kun Wang, Alfredo Molinolo, Eytan Ruppin, Rabi Murad, Ze’ev A. Ronai   +7 more
openalex   +1 more source

Teething on Toxins: In Search of Regulatory Solutions for Toys and Cosmetics [PDF]

, 2009
Rawlins, Rachael
core   +1 more source

A multi‐level approach for multi‐objective optimization in process eco‐design

Environmental Progress &Sustainable Energy, EarlyView.
Abstract This work addresses a central challenge in process eco‐design: how to efficiently integrate environmental and economic criteria—often conflicting—into early design stages while managing the high dimensionality of Life Cycle Assessment (LCA) indicators.
Luis Fernando Morales‐Mendoza, Catherine Azzaro‐Pantel, Ingrid Eileen Ortega‐Gutiérrez, Iris Abril Martínez‐Salazar   +3 more
wiley   +1 more source