Results 241 to 250 of about 310,687 (304)

Role of P450 enzymes of the Cyp2abfgs gene subfamilies in tobacco smoke-induced lung tumorigenesis in mice. [PDF]

Carcinogenesis
Tran LM, Edwards PC, Yang W, Zhang QY, Han W, Kovalchuk N, Ding L, Wu X, Fan X, Arredondo A, Merluza RJA, Besselsen DG, Reader JR, Van Winkle LS, Ding X.   +14 more
europepmc   +1 more source

Mode‐of‐Action and Human Relevance Assessment for Diisononyl Phthalate‐Induced Liver Tumors in Rodents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger, Melissa M. Heintz, Laurie C. Haws, Chad M. Thompson   +3 more
wiley   +1 more source

Environmental Impact Assessment of Using Waste Tires as an Alternative Fuel in a Cement Clinker Production Plant in China: A Case Study. [PDF]

Materials (Basel)
Li W, Wu J, Mao Q, Xu C.
europepmc   +1 more source

Biochemical and Molecular Insights Into Monocrotaline‐Induced Hepatotoxicity: An Experimental Mouse Study

Journal of Applied Toxicology, EarlyView.
ABSTRACT Monocrotaline (MCT), a plant‐derived pyrrolizidine alkaloid, is well known for its hepatotoxic effects. However, full elucidation of the mechanisms underlying MCT‐induced hepatotoxicity, as well as the development of reliable biomarkers for early detection and monitoring, requires an integrated evaluation of biochemical, molecular, and ...
Ali Şenol, Alparslan Kadir Devrim, Miyase Çinar, Mahmut Sözmen, Fatma Betül Akça   +4 more
wiley   +1 more source

Air Pollution Quinones Impair Intestinal Barrier Integrity and Endoplasmic Reticulum in Differentiated Caco‐2 Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Particulate matter (PM) is a major global health threat, linked to millions of deaths annually. Beyond inhalation, PM components reach the gastrointestinal tract through the mucociliary escalator or contaminated food and water. Among PM's organic fraction, redox‐active quinones such as 1,2‐naphthoquinone (NQ) and 9,10‐phenanthrenequinone (PQ ...
Franco Cervellati, Giulia Trinchera, Alice Casoni, Alessandra Pecorelli, Mascia Benedusi, Maria Chiara Pietrogrande, Giuseppe Valacchi   +6 more
wiley   +1 more source

CarD-T: an automated pipeline for the nomination and analysis of potential human carcinogens. [PDF]

Carcinogenesis
O'Neill J, Reddy GA, Dhillon N, Tripathi O, Alexandrov L, Katira P.   +5 more
europepmc   +1 more source

A Comprehensive Study to Compare Different Compound Representations for Predicting Carcinogenicity In Vivo

Journal of Applied Toxicology, EarlyView.
ABSTRACT Carcinogenicity evaluation is a critical component of chemical risk assessment, yet traditional in vivo testing remains time consuming, costly, and ethically challenging. Computational approaches based on machine learning offer promising alternatives, but the relative contributions of different molecular representation strategies for ...
Iuri Barbosa Pereira, Rogerio Salvini, Eloisa Dutra Caldas   +2 more
wiley   +1 more source

Ancestry informative genetic variants associated with tobacco metabolic and detoxification capacity measured by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) among smokers. [PDF]

Arch Toxicol
Lanade O, He Z, Zhou Y, Blackman E, Gibbs D, Harrison S, Devarajan K, Andrake M, Dunbrack RL, Nkogbu G, Wagh A, Slifker M, Erkmen C, Patterson F, Satti A, Lawson-Myers HD, Roberts R, Mitchell D, Liu JC, Erblich J, Ragin C.   +20 more
europepmc   +1 more source

From Chlorophyll to Micro Biome: Wheatgrass's Role in Gut Health-A Comprehensive Review. [PDF]

Int J Prev Med
Alva R, Shenoy D, Shetty V.
europepmc   +1 more source

A signature-agnostic test for differences between tumor mutation spectra reveals carcinogen and ancestry effects. [PDF]

Commun Biol
Hart SFM, Alcala N, Feder AF, Harris K.
europepmc   +1 more source