Results 271 to 280 of about 374,979 (291)

Mother and child environmental carcinogens exposure history: a tool to bridge environmental health and clinical sciences

Jaqueline Calderón, Lizet Jarquin Yañez, Jessica Campos Moroyoqui   +2 more
openalex   +1 more source

HIF2A as a prognostic and clinical therapeutic target in ovarian clear cell carcinoma

International Journal of Cancer, EarlyView.
What's New? Ovarian clear cell carcinoma is highly associated with hypoxia. Hypoxia‐inducible factor 2A (HIF2A) is a key regulator of hypoxic responses, but its role in ovarian clear cell carcinoma remains unclear. This study demonstrated the unfavorable prognostic significance of HIF2A expression in ovarian clear cell carcinoma.
Mengxin Jiang, Ken Yamaguchi, Kohei Hamada, Yuko Hosoe, Yuka Mise, Sachiko Kitamura, Zhihong Liu, Hairong Wei, Zhenhai Gao, Mana Taki, Koji Yamanoi, Ryusuke Murakami, Rin Mizuno, Taito Miyamoto, Junzo Hamanishi, Masaki Mandai   +15 more
wiley   +1 more source

PharmaceuticalNitrosamines: A Comprehensive Reviewof Health Risks, Detection, Mitigation Strategies Supplemented withCYP450 Interactions as Molecular Simulations for Mechanistic Insightinto Carcinogenicity

Kardile Punam Kashinath (21787467), Md Samim Sardar (21787470), Subhadeep Roy (1274595), Anoop Kumar (44), Santanu Kaity (1755532)   +4 more
openalex   +1 more source

Global Burden of Hematologic Malignancies From 1990 to 2021 With Projections to 2030: A Systematic Analysis for the Global Burden of Disease Study 2021

iNew Medicine, EarlyView.
ABSTRACT This study aimed to comprehensively analyze the epidemiological trends and global burden of hematologic malignancies (HM) from 1990 to 2021 and to project trends up to the year 2030. Using data from the Global Burden of Disease (GBD) Study 2021, we analyzed the age‐standardized rates (ASRs) and the trends of HM from 1990 to 2021. Decomposition
Ziyuan Shen, Linyu Huang, Xing Xing, Danting Zhang, Guoqi Cai, Wei Sang   +5 more
wiley   +1 more source

The key characteristics concept. [PDF]

Curr Opin Toxicol
Smith MT.
europepmc   +1 more source

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

Compensation for Patients with Work-Related Lung Cancers: Value of Specialised Occupational Disease Consultations to Reduce Under-Recognition. [PDF]

Int J Environ Res Public Health
Roux C, Fafin-Lefevre M, Morello R, Boullard L, Clin B.   +4 more
europepmc   +1 more source

Chinese pan‐cancer patient genomic characteristics: A comprehensive analysis based on the National Cancer Center–Clinical Diagnostics Knowledgebase real‐world clinical sequencing cohort

Interdisciplinary Medicine, EarlyView.
We assembled National Cancer Center–Clinical Diagnostics Knowledgebase, a clinical genomic knowledgebase of 6935 tumors with matched normal samples, revealing key somatic alterations and actionable variants (70.2% of the cohort). Enrichment of certain different gene mutations was observed between Chinese and American populations, along with a strong ...
Hongrui Li, Shun Wang, Guowei Zhao, Jiangtao Li, Xin Li, Bingning Wang, Yi Zhang, Mengfei Yao, Lei Guo, Jianming Ying, Wenbin Li   +10 more
wiley   +1 more source

Methodological Pitfalls Undermine Industrial Emission-related Lung Cancer Risk Assessment. [PDF]

Am J Respir Crit Care Med
Zhou D, Wang H, Zhu X.
europepmc   +1 more source

Use of the TIPS Technique as a Possible Method of Acute Inhalation Toxicity Assessment

Journal of Applied Toxicology, EarlyView.
ABSTRACT Acute inhalation toxicity studies provide crucial information regarding short‐term exposure to volatile chemicals and help to ensure the safe handling and use of these chemicals. However, acute inhalation toxicity assessment requires specialized equipment, and most animal facilities are not able to carry out such studies.
Dina Mourad Saleh, Omnia Hosny Mohamed Ahmed, David B. Alexander, William T. Alexander, Kumiko Ogawa, Min Gi, Aya Naiki‐Ito, Salwa Abdallah, Hiroyuki Tsuda   +8 more
wiley   +1 more source