Results 91 to 100 of about 2,051,186 (321)

Overexpression of Cullin7 is associated with hepatocellular carcinoma progression and pathogenesis

BMC Cancer, 2017
Background Overexpression of Cullin7 is associated with some types of malignancies. However, the part of Cullin7 in hepatocellular carcinoma remains unclear. The aim of this study was to investigate the role of Cullin7 in pathogenesis and the progression
Jun An, Zhigang Zhang, Zhiyong Liu, Ruizhi Wang, Dayang Hui, Yi Jin   +5 more
doaj   +1 more source

Clinical features and diagnostic imaging of cholangiolocellular carcinoma compared with other primary liver cancers: a surgical perspective

Technology in Cancer Research & Treatment, 2020
Background and Objectives: Although cholangiolocellular carcinoma is considered a combined hepatocellular and cholangiocarcinoma, we feel that this classification is not appropriate.
Hiroyuki Takamura PhD, MD, Ryousuke Gabata MD, Yoshinao Obatake PhD, MD, Shinichi Nakanuma PhD, MD, Hironori Hayashi PhD, MD, Kazuto Kozaka PhD, MD, Motoko Sasaki PhD, MD, Mitsuyoshi Okazaki PhD, MD, Takahisa Yamaguchi PhD, MD, Hiroyuki Shimbashi PhD, MD, Shiro Terai PhD, MD, Koichi Okamoto PhD, MD, Isamu Makino PhD, MD, Jun Kinoshita PhD, MD, Keishi Nakamura PhD, MD, Tomoharu Miyashita PhD, MD, Hidehiro Tajima PhD, MD, Itasu Ninomiya PhD, MD, Sachio Fushida PhD, MD, Azusa Kitao PhD, MD, Masaaki Kitahara PhD, MD, Kuniaki Arai PhD, MD, Taro Yamashita PhD, MD, Tatsuya Yamashita PhD, MD, Hiroko Ikeda PhD, MD, Yasunori Satoh PhD, MD, Kenichi Harada PhD, MD, Syuichi Kaneko PhD, MD, Toshihumi Gabata PhD, MD, Tateo Kosaka PhD, MD, Tetsuo Ohta PhD, MD   +30 more
doaj   +1 more source

Enhanced expression of miR-889 forecasts an unfavorable prognosis and facilitates cell progression in hepatocellular carcinoma

Diagnostic Pathology, 2021
Background As a new type of molecular marker, microRNAs (miRNAs) can be used for early diagnosis and prognosis prediction of malignant tumors, and has broad clinical application prospects.
He Wang, Huiwen Wang, Wenyu Cui, Qiao Zhang, Jing Li, Qi Zhang   +5 more
doaj   +1 more source

Advances in immunotherapy for hepatocellular carcinoma

Nature reviews: Gastroenterology & hepatology, 2021
Hepatocellular carcinoma (HCC) is a prevalent disease with a progression that is modulated by the immune system. Systemic therapy is used in the advanced stage and until 2017 consisted only of antiangiogenic tyrosine kinase inhibitors (TKIs ...
B. Sangro, P. Sarobe, S. Hervás-Stubbs, I. Melero   +3 more
semanticscholar   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

The activation of the Notch signaling pathway by UBE2C promotes the proliferation and metastasis of hepatocellular carcinoma

Scientific Reports
UBE2C, a ubiquitin-conjugating enzyme, functions as an oncogene in different types of human cancers. Nonetheless, the exact influence of UBE2C on the development of HCC via regulation of ubiquitination remains uncertain.
Ping Zhan, Yuyan Lu, Jing Lu, Yizhe Cheng, Changhong Luo, Fan Yang, Wenqing Xi, Jinzhu Wang, Xuesong Cen, Fuqiang Wang, Chengrong Xie, Zhenyu Yin   +11 more
doaj   +1 more source

Protein arginine N-methyltransferase 1 promotes the proliferation and metastasis of hepatocellular carcinoma cells

Tumor Biology, 2017
Hepatocellular carcinoma is the most common subtype of liver cancer. Protein arginine N-methyltransferase 1 was shown to be upregulated in various cancers.
Qing Gou, ShuJiao He, ZeJian Zhou
doaj   +1 more source

N6-Methyladenosine RNA Methylation Regulators Have Clinical Prognostic Values in Hepatocellular Carcinoma

Frontiers in Genetics, 2020
Although it is widely accepted that N6-methyladenosine (m6A) RNA methylation plays critical roles in tumorigenesis and progression, the values of m6A modification are less known in hepatocellular carcinoma.
Wei Liu, Cuiqing Zhong, Deguan Lv, Mengjie Tang, Feng Xie   +4 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source