Results 101 to 110 of about 1,853,915 (311)

International trends in hepatocellular carcinoma incidence, 1978–2012

International Journal of Cancer, 2020
Primary liver cancer, the major histology of which is hepatocellular carcinoma (HCC), is the second leading cause of cancer death worldwide. We comprehensively examined recent international trends of primary liver cancer and HCC incidence using ...
J. Petrick, Andrea A. Florio, A. Znaor, David Ruggieri, M. Laversanne, Christian S. Alvarez, J. Ferlay, P. Valery, F. Bray, K. McGlynn   +9 more
semanticscholar   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Sugar Alcohols Have a Key Role in Pathogenesis of Chronic Liver Disease and Hepatocellular Carcinoma in Whole Blood and Liver Tissues. [PDF]

, 2020
The major risk factors for hepatocellular carcinoma (HCC) are hepatitis C and B viral infections that proceed to Chronic Liver Disease (CLD). Yet, the early diagnosis and treatment of HCC are challenging because the pathogenesis of HCC is not fully ...
El-Said, Hala, Elfert, Ashraf, Fiehn, Oliver, Helal, Marwa, Ismail, Israa T, Salama, Ibrahim   +5 more
core   +2 more sources

Diagnosis of hepatocellular carcinoma

Diagnostic and Interventional Imaging, 2014
More than 90% of cases of hepatocellular carcinoma occur on the background of chronic liver disease. Its diagnosis should therefore be based on six-month ultrasound screening, which should be started in these patients. The positive diagnosis of hepatocellular carcinoma is based on its vascularization examined on dynamic CT or MRI images after contrast ...
Cartier, Victoire, Aubé, Christophe
openaire   +5 more sources

Targeted therapy for hepatocellular carcinoma

Signal Transduction and Targeted Therapy, 2020
The last 3 years have seen the emergence of promising targeted therapies for the treatment of hepatocellular carcinoma (HCC). Sorafenib has been the mainstay of treatment for a decade and newer modalities were ineffective and did not confer any increased
Ao Huang, Xinrong Yang, W. Chung, A. Dennison, Jian Zhou   +4 more
semanticscholar   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Protein induced by vitamin K absence or antagonist-II (PIVKA-II) specifically increased in Italian hepatocellular carcinoma patients [PDF]

, 2016
OBJECTIVE: As a marker for Hepatocellular Carcinoma (HCC), Protein Induced by Vitamin K Absence II (PIVKA-II) seems to be superior to alpha fetoprotein (AFP).
Anastasi, Emanuela, Angeloni, Antonio, D'Ettorre, Gabriella, DE VITO, Corrado, Frati, Luigi, Gennarini, Giuseppina, Palombi, S, Viggiani, Valentina   +7 more
core   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression [PDF]

, 2017
Gastrointestinal cancer is a group of tumors that affect multiple sites of the digestive system, including the stomach, liver, colon and pancreas. These cancers are very aggressive and rapidly metastasize, thus identifying effective targets is crucial ...
Bacigalupo, Maria Lorena, Carabias, Pablo, Troncoso, María Fernanda   +2 more
core   +1 more source

Hook1 inhibits malignancy and epithelial–mesenchymal transition in hepatocellular carcinoma

Tumor Biology, 2017
Hook1 is a member of the hook family of coiled-coil proteins, which is recently found to be associated with malignant tumors. However, its biological function in hepatocellular carcinoma is yet unknown.
Xu Sun, Qi Zhang, Wei Chen, Qida Hu, Yu Lou, Qi-Han Fu, Jing-Ying Zhang, Yi-Wen Chen, Long-Yun Ye, Yi Wang, Shang-Zhi Xie, Li-Qiang Hu, Ting-Bo Liang, Xue-Li Bai   +13 more
doaj   +1 more source