Results 111 to 120 of about 1,853,915 (311)

Asia–Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update

Hepatology International, 2017
There is great geographical variation in the distribution of hepatocellular carcinoma (HCC), with the majority of all cases worldwide found in the Asia–Pacific region, where HCC is one of the leading public health problems.
M. Omata, A. Cheng, N. Kokudo, M. Kudo, J. Lee, J. Jia, R. Tateishi, K. Han, Y. K. Chawla, S. Shiina, W. Jafri, D. Payawal, Takamasa Ohki, S. Ogasawara, Pei‐Jer Chen, C. Lesmana, L. Lesmana, R. Gani, S. Obi, A. Dokmeci, S. Sarin   +20 more
semanticscholar   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Ferritin level prospectively predicts hepatocarcinogenesis in patients with chronic hepatitis B virus infection [PDF]

, 2018
Previous studies have detected a higher level of ferritin in patients with hepatocellular carcinoma (HCC), but a potential causal association between serum ferritin level and hepatocarcinogenesis remains to be clarified.
Bian, Zhenyuan, Fang, Wan, Hann, Hie-Won, Tao, Kaishan, Wan, Shaogui, Wang, Chun, Wang, Yang, Ye, Zhong, Yin, Chun   +8 more
core   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Multimodality Treatment with Conventional Transcatheter Arterial Chemoembolization and Radiofrequency Ablation for Unresectable Hepatocellular Carcinoma [PDF]

, 2012
Background/Aims: To evaluate the efficacy of multimodality treatment consisting of conventional transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) in patients with non-resectable and non-ablatable hepatocellular carcinoma ...
Albrecht T, Bloomston M, Bosch FX, Bruix J, Bruix J, Buscarini E, Buscarini L, Buscarini L, C. Trumm, Camma C, Clasen S, Dupuy DE, El-Serag HB, F. Bamberg, F.T. Kolligs, Geschwind JF, Jemal A, Kagawa T, Kettenbach J, Kim JH, Kirikoshi H, Lencioni R, Lencioni R, Lencioni R, Lencioni RA, Lin SM, Lin SM, Livraghi T, Livraghi T, Llovet JM, Llovet JM, Lo CM, M. Rentsch, M.F. Reiser, Marelli L, Marrero JA, N. Ashoori, Oken MM, P. Paprottka, Parkin DM, Poon RT, Rossi S, Sherman M, Shiina S, T.F. Jakobs, Veltri A, Vetter D, Yamakado K, Zhang L   +48 more
core   +1 more source

SIRT3 functions as a tumor suppressor in hepatocellular carcinoma

Tumor Biology, 2017
Hepatocellular carcinoma is one of the leading causes for cancer-related mortality worldwide. SIRT3 may function as either oncogene or tumor suppressor in a panel of cancers; however, the role of SIRT3 in hepatocellular carcinoma remains unclear. In this
Xianchun Zeng, Nanzhu Wang, Hui Zhai, Rongpin Wang, Jiahong Wu, Wei Pu   +5 more
doaj   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Abnormal prothrombin (DES-y-Carboxy Prothrombin) in hepatocellular carcinoma [PDF]

, 1991
Des-γ-carboxy prothrombin (DCP), a protein induced by vitamin K absence or antagonist-II (PIVKA-II) was measured by an enzyme immunoassay (E-1023) using anti-DCP monoclonal antibody in 92 patients with various hepatobiliary diseases. Thirty-six of the 38
Carr, B, Iwaki, Y, Iwatsuki, S, Nakao, A, Starzl, E, Virji, A   +5 more
core  

Liver imaging reporting and data system: An expert consensus statement [PDF]

, 2017
The increasing incidence and high morbidity and mortality of hepatocellular carcinoma (HCC) have inspired the creation of the Liver Imaging Reporting and Data System (LI-RADS).
Agrons, Michelle M, Bashir, Mustafa R, Chernyak, Victoria, Do, Richard K, Elsayes, Khaled M, Fowler, Kathryn J, Kielar, Ania Z, Mitchell, Donald G, Sirlin, Claude B, Szklaruk, Janio, Tang, An   +10 more
core   +2 more sources