Results 141 to 150 of about 454,519 (294)

Frailty and surgical outcomes in gastrointestinal cancer: Integration of geriatric assessment and prehabilitation into surgical practice for vulnerable patients

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 27-41, January 2023., 2023
Accumulating evidence demonstrates that the integration of preoperative geriatric assessment and prehabilitation for frail patients into clinical practice may improve perioperative and long‐term outcomes in patients with gastrointestinal cancer. We proposed an example for the integration of older patients‐specific care into treatment strategies for ...
Kosuke Mima, Shigeki Nakagawa, Tatsunori Miyata, Yo‐ichi Yamashita, Hideo Baba   +4 more
wiley   +1 more source

GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy

Advanced Science, EarlyView.
A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang, Runhua Zhou, Chengchao Xu, Lingyun Dai, Rui Hou, Liuhai Zheng, Chunjin Fu, Guangwei Shi, Jingwei Wang, Yang Li, Jinpeng Cen, Xiaolong Xu, Le Yu, Yilei Li, Jigang Wang, Qingfeng Du, Zhijie Li   +16 more
wiley   +1 more source

Tumor budding may be a promising prognostic indicator in intrahepatic cholangiocarcinoma: A multicenter retrospective study

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 138-146, January 2023., 2023
High tumor budding is a new candidate for an additional determinant of the T category in staging ICC. An LCSGJ staging system containing an additional evaluation of tumor budding may lead to improved staging accuracy. Abstract Purpose This retrospective study evaluated our hypothesis that high tumor budding (≥10 buds) may help determine the appropriate
Hisashi Kosaka, Mitsuaki Ishida, Masaki Ueno, Koji Komeda, Daisuke Hokutou, Hiroya Iida, Fumitoshi Hirokawa, Kosuke Matsui, Mitsugu Sekimoto, Masaki Kaibori   +9 more
wiley   +1 more source

Organelle-Partitioned Sugar–Rhodamine Diad for In Vivo Tumor Imaging

ACS Omega, 2020
Enkang Zhang, Chaozhang Yu, Hui Tang, Yuntong Li, Dongliang Zuo, Rongshui Yang, Chao Ma, Jiayin Miao, Pingguo Liu, Xinhui Su   +9 more
doaj   +1 more source

CCDC167 promotes hepatocellular carcinoma cell proliferation and is associated with the immune microenvironment of hepatocellular carcinoma

Arabian Journal of Chemistry
Coiled-coil domain-containing (CCDC)family proteins play an important role in tumour progression, however, the role of CCDC167 in hepatocellular carcinoma remains unclear.
Qianwen Wang, Wenhua Li, Junxia Lu, Bin Zhao, Yuqing Geng, Xiangwei Wu, Xueling Chen   +6 more
doaj  

Autophagy-related long non-coding RNA MIR210HG plays a therapeutic role in hepatocellular carcinoma

Discover Oncology
Objective This study aimed to investigate the role of the autophagy-related long noncoding RNA (lncRNA) MIR210HG in hepatocellular carcinoma and its potential as a therapeutic target.
Chaoqun Zhang, Dianxing Sun, Huifang Zhou, Chao Liu, Jie Ruan, Jiwen Kang, Ying Xie   +6 more
doaj   +1 more source

Construction and evaluation of optimal diagnostic tests with application to hepatocellular carcinoma diagnosis [PDF]

arXiv
Accurate diagnostic tests are crucial to ensure effective treatment, screening, and surveillance of diseases. However, the limited accuracy of individual biomarkers often hinders comprehensive screening. The heterogeneity of many diseases, particularly cancer, calls for the use of several biomarkers together into a composite diagnostic test.
arxiv  

FGF2 Mediated USP42‐PPARγ Axis Activation Ameliorates Liver Oxidative Damage and Promotes Regeneration

Advanced Science, EarlyView.
USP42 is identified as a novel DUB of PPARγ in hepatocytes. USP42 mediated PPARγ deubiquitylation determines its transcriptional preference on proliferative and redox balance genes. USP42 knockdown exacerbates liver damage and delays regeneration. FGF2 is the upstream signal that initiates and activates the USP42‐PPARγ axis.
Nanfei Yang, Qiang Tian, Zhenli Lei, Shuxin Wang, Nan Cheng, Zhen Wang, Xianqin Jiang, Xuqun Zheng, Wenjing Xu, Minyan Ye, Longwei Zhao, Meiyun Wen, Jianlou Niu, Weijian Sun, Pingping Shen, Zhifeng Huang, Xiaokun Li   +16 more
wiley   +1 more source

Clinical outcomes of single incision laparoscopic surgery for colorectal cancer: A propensity score‐matched analysis between well‐experienced and novice surgeons

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 102-109, January 2023., 2023
SILS is a technically challenging procedure for novice surgeons. We evaluate the clinical outcomes of SILS for colorectal cancer performed by novice surgeons. SILS was safely performed by novice surgeons under the guidance of well‐experienced surgeons, and could provide satisfactory oncological outcomes. Abstract Background Single incision laparoscopic
Mitsuyoshi Tei, Yozo Suzuki, Masahisa Ohtsuka, Kazuya Iwamoto, Atsushi Naito, Mitsunobu Imasato, Tsunekazu Mizushima, Hiroki Akamatsu   +7 more
wiley   +1 more source

A rare presentation of hepatocellular carcinoma in non-cirrhotic liver

The Pan African Medical Journal, 2017
Hepatocellular carcinoma is the most frequent type of liver malignancy. Most cases of hepatocellular carcinoma are secondary to either viral hepatitis (hepatitis B, C) or alcoholic cirrhosis.
Lamia Kabbage, Meryem El kouhen, Ahmed Taghy, Kaoutar Znati, Nawal Kabbaj   +4 more
doaj   +1 more source