Results 181 to 190 of about 1,627,756 (267)

Correction: Comprehensive analysis of bioinformatics and system biology reveals the association between Girdin and hepatocellular carcinoma. [PDF]

PLoS One
PLOS One Staff.
europepmc   +1 more source

A Novel Self‐Regulated, Non‐Directional Magnetic Thermos‐Brachytherapy 125I Seed Enhances Anticancer Efficacy by Rescuing Immune Escape

Advanced Science, EarlyView.
This work constructs magnetic nanoparticles (MNPs) and incorporates them with silver rods coated with 125I to form a novel composite seed, which exhibits direction‐independent and self‐regulated heating efficiency, as well as the capacity of preventing MNPs leakage and enabling repeated hyperthermia.
Bin Xu, Ye‐Ming Wu, Yi‐Fei Cheng, Lei Dong, Shuai‐Wen Ding, Sheng‐Rong Chen, Bin‐Da Chen, Ren‐Peng Yang, Wei‐Hua Zhang, Ya‐Jie Wang, Wei‐Pu Mao, Fan Shi, Zhi‐Cheng Jin, Jian‐Jian Chen, En‐Qi Qiao, Yu‐Qing Wang, Jin‐Ze Li, Peng Zeng, Cheng‐Wei Wu, Wei Zhang, Jin‐Bing Xie, Jian Lu, Gao‐Jun Teng   +22 more
wiley   +1 more source

Zinc Alleviates Gut Barrier Dysfunction by Promoting the Methylation of AKT

Advanced Science, EarlyView.
Zinc activates the ZNG1‐METAP1 complex to elevate intracellular SAM levels, which promotes PRMT5‐mediated symmetrical dimethylation of AKT at R391 and R15. This epigenetic modification facilitates AKT membrane translocation and mTORC2 activation, thereby enhancing epithelial proliferation and gut barrier integrity.
Chuanjiang Cai, Yining Zheng, Bo Sun, Guoyan Wang, Pengfei Li, Huijun Geng, Rongnuo Li, Miaomiao Zhu, Yuanyuan Zhu, Dingping Feng, Lei Chen, Guiyan Chu, Lu Deng, Shiyan Qiao   +13 more
wiley   +1 more source

Association between glycemic control and hepatocellular carcinoma risk in people with type 2 diabetes, stratified by chronic hepatitis B or C infection. [PDF]

Therap Adv Gastroenterol
Chen IW, Huang CH, Liu PH, Lin CW, Hung SY, Huang YY.   +5 more
europepmc   +1 more source

SNORA58 Facilitates Radioresistance via Suppressing JNK1‐Mediated Ferroptosis in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
In ESCC patients, SNORA58 exhibits heterogeneous expression patterns. Its aberrant overexpression stabilizes CTCF by inhibiting ubiquitin‐mediated degradation, leading to the attenuation of JNK1‐mediated ferroptosis induced by radiotherapy through disruption of intracellular iron homeostasis, and ultimately contributes to radioresistance ...
Yinli Zheng, Fangyi Liu, Yuhua Huang, Yanfen Feng, Xia Yang, Jinjun Wu, Xin Yang, Xuanhao Lin, Lives Jiang, Tingting Zeng, Yan Li, Xinyuan Guan, Yuanyuan Wang, Chunyan Chen, Jingping Yun   +14 more
wiley   +1 more source

Correction : Glutathiones' life in multi-cancers: especially their potential micropetides in liver hepatocellular carcinoma. [PDF]

Discov Oncol
Ma D, Wu Z, Zhang M, Mao J, Xu W, Jiang L, Wang Z.   +6 more
europepmc   +1 more source

Clathrin Light Chain B Drives Hepatocellular Carcinoma Progression Through Dual Mechanisms: Small Extracellular Vesicle‐Mediated Angiogenesis and the NF‐κB–PCLAF Signaling Axis

Advanced Science, EarlyView.
Clathrin Light Chain B (CLTB) drives hepatocellular carcinoma progression through dual pathways: intracellularly, it activates the NF‐κB–PCLAF axis to enhance small extracellular vesicle (sEV) uptake and tumor proliferation; extracellularly, CLTB‐enriched sEVs bind SH3KBP1 to inhibit its degradation, inducing angiogenesis and vascular leakage ...
Xiaoke Sun, Junchen Guo, Ning Zhao, Guanghua Cui, Yun Bai, Meijuan Ding, Yi Xu, Yu Yang   +7 more
wiley   +1 more source

Stereotactic radiotherapy with Gamma Master System^® for palliation of hepatocellular carcinoma in patients with liver cirrhosis. [PDF]

Radiat Oncol
Qiu B, Fang F, Zhen P, Wang J.
europepmc   +1 more source

Insights into the Mechanisms of Immune‐Checkpoint Inhibitors Gained from Spatiotemporal Dynamics of the Tumor Microenvironment

Advanced Science, EarlyView.
This review summarizes recent advances in the spatiotemporal dynamics of the tumor microenvironment (TME). It highlights the roles of diverse immune and stromal cell populations, spatial architecture of the TME, as well as the gut and tumor microbiota in influencing responses to immune checkpoint inhibitors (ICIs), by integrating insights from single ...
Yuanyuan Zhang, Zhihua Liu
wiley   +1 more source

Prediction of Lung Cancer Metastasis Risk Based on Single‐Cell Metabolic Profiling of Circulating Tumor Cells

Advanced Science, EarlyView.
A self‐developed CTC sorting and capture platform enabled single‐cell metabolomics of patient/animal CTCs, revealing brain/bone metastasis‐specific metabolic signatures. A classification model developed from these signatures predicted lung cancer metastasis risk, outperforming traditional markers and total CTC counts (AUCs:89 brain = 0.74; bone = 0.92).
Yang Xu, Xuesen Hu, Yuan Yuan, Wenwen Liu, Jian Wang, Chunhui Yang, Xianzhe Shi, Wangshu Qin, Liliang Wen, Manqing Lin, Yinuo Jin, Wei Wang, Chunxiu Hu, Guowang Xu, Qi Wang   +14 more
wiley   +1 more source