Results 181 to 190 of about 454,519 (294)

Autophagy Related 5 Promotes Mitochondrial Fission and Inflammation via HSP90‐HIF‐1α‐Mediated Glycolysis in Kidney Fibrosis

Advanced Science, EarlyView.
When the normal kidney is subjected to injurious stimuli, it can lead to persistent activation of ATG5. The activation of ATG5 promotes HSP90‐HIF‐1α interaction, resulting in stabilization of HIF‐1α and subsequent activation of glycolysis. Consequently, this process contributes to mitochondrial fission and inflammation, ultimately culminating in kidney
Yan Hu, Jinqing Li, Hui Chen, Yingfeng Shi, Xiaoyan Ma, Yi Wang, Xialin Li, Qin Zhong, Yishu Wang, Daofang Jiang, Shougang Zhuang, Na Liu   +11 more
wiley   +1 more source

A Novel tRF, HCETSR, Derived From tRNA‐Glu/TTC, Inhibits HCC Malignancy by Regulating the SPBTN1‐catenin Complex Axis

Advanced Science, EarlyView.
HCETSR, derived from tRNA‐Glu/TTC, binds to SPTBN1, promoting the dissociation of SPTBN1 from the catenin complex and facilitating the translocation of the catenin complex from the cell membrane to the nucleus. Meanwhile, HCETSR reduces proteasomal degradation of β‐catenin and synthesis of nascent β‐catenin.
Tao Rui, Kangbei Zhu, Zonglei Mao, Jiaping Wu, Yi Pan, Qianwei Ye, Cong Chen, Aizhai Xiang, Jufeng Guo, Ning Tang, Jing Zhang, Shusen Zheng, Jian Liu, Xiao Xu   +13 more
wiley   +1 more source

RAB3B Dictates mTORC1/S6 Signaling in Chordoma and Predicts Response to mTORC1‐Targeted Therapy

Advanced Science, EarlyView.
RAB3B is unveiled as a prominent oncogenic regulator in chordoma, which can block the DUSP12‐mediated dephosphorylation of p‐S6 (S235/236). The combination of RAB3B and p‐S6 indicates a good prognostic value and predicts mTORC1 inhibitors response for chordoma patients.
Jianxuan Gao, Jiali Jin, Runzhi Huang, Siqiao Wang, Sihui Song, Yu Zhang, Yongai Li, Jun Lin, Zhengyan Chang, Zongqiang Huang, Wei Sun, Huabin Yin, Dianwen Song, Jianru Xiao, Ping Wang, Tong Meng   +15 more
wiley   +1 more source

Cobalt Single‐Atom Intercalation in Molybdenum Disulfide Enhances Piezocatalytic and Enzyodynamic Activities for Advanced Cancer Therapeutics

Advanced Science, EarlyView.
The single‐atom doped molybdenum disulfide piezocatalyst markedly enhances both piezoelectric and enzyme‐mimicking activities, accelerating glutathione depletion. It induces mitochondrial dysfunction and cell cycle arrest, ultimately driving apoptosis while inactivating glutathione peroxidase 4 to initiate ferroptosis.
Haomiao Bai, Sujun Ding, Yanfei Dai, Jiefu Liu, Huangjing Chen, Wei Feng, Dehong Yu, Yu Chen, Xuejun Ni   +8 more
wiley   +1 more source

Prevalence and management of proteinuria associated with vascular endothelial growth factor receptor-targeted tyrosine kinase inhibitor treatment in advanced renal cell carcinoma, hepatocellular carcinoma, and thyroid cancer. [PDF]

Int J Urol
Kato T, Mizuno R, Miyake H.
europepmc   +1 more source

MISP Suppresses Ferroptosis via MST1/2 Kinases to Facilitate YAP Activation in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
This study explores the role of Mitotic Spindle Positioning (MISP) as a key inhibitor of ferroptosis in non‐small cell lung cancer (NSCLC). MISP upregulation in NSCLC tissues leads to ferroptosis resistance, promoting cell proliferation. Mechanistically, MISP suppresses Hippo signaling via MST1/2 kinases, activating YAP and enhancing SLC7A11 expression,
Fuquan Zhang, Bingtao Huang, Yiming Xu, Guohong Cao, Mingjing Shen, Changmin Liu, Judong Luo   +6 more
wiley   +1 more source

A Chemotherapy Response-Related Gene Signature and DNAJC8 as Key Mediators of Hepatocellular Carcinoma Progression and Drug Resistance. [PDF]

J Hepatocell Carcinoma
Ye Y, Zeng Y, Huang S, Zhu C, Wang Q.
europepmc   +1 more source

LIMA1 O‐GlcNAcylation Promotes Hepatic Lipid Deposition through Inducing β‐catenin‐Regulated FASn Expression in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
Early diagnosis and treatment of metabolic dysfunction‐associated steatotic liver disease (MASLD) remains a significant challenge. This study indicates that serum sEV LIMA1 may serve as a noninvasive biomarker for MASH. The HCF1/OGT complex induces O‐GlcNAcylation of the LIMA1 protein, and subsequently promotes lipid accumulation in hepatocytes by ...
Fuji Yang, Yifei Chen, Guojun Zheng, Kefeng Gu, Lin Fan, Tingfen Li, Ling Zhu, Yongmin Yan   +7 more
wiley   +1 more source

ISG15 Enhances the Activity of γ‐Glutamate Cysteine Ligase to Suppress Apoptosis in High Fat Diet‐Promoted Hepatocellular Carcinoma

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC) cells under high‐fat environment constrain harmful reactive oxygen species (ROS) by enhancing glutathione synthesis though upregulating interferon stimulated gene 15 (ISG15). In this process, upregulated high mobility group A1 (HMGA1) enhances ISG15 transcription, upregulated ISG15 subsequently noncovalently binds with ...
Xinran Liu, Qiujin Ma, Zhao Jia, Yihao Zhou, Churong Zou, Yushuo Xiao, Yuchen Chen, Chuyao Ma, Liangliang Song, Jing Yang, Chen Wang, Huidie Xu, Hong Chen, Jiajian Shi, Junqiu Yue, Yu Sun, Desheng Hu, Robert B Petersen, Yangkai Li, Anlin Peng, Kun Huang, Ling Zheng   +21 more
wiley   +1 more source

MicroRNA‐433‐3p enhances chemosensitivity of glioma to cisplatin by downregulating NR5A2

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
miR‐433‐3p mediated the ability of NR5A2 to regulate the malignant behavior of glioma cells Abstract Objective We attempted to investigate influence of microRNA‐433‐3p on malignant progression of glioma and identify its molecular mechanism, thus laying groundwork for glioma management.
Jun Li, Jingshun Gu, Juntong Wang, Aiwu You, Yuyan Zhang, Guomin Rao, Shuang Li, Xuehua Ge, Kun Zhang, Dongchun Wang   +9 more
wiley   +1 more source