Results 11 to 20 of about 1,627,756 (267)

RBCK1 promotes hepatocellular carcinoma metastasis and growth by stabilizing RNF31

Cell Death Discovery, 2022
RNF31 (HOIP), RBCK1 (HOIL-1L), and SHARPIN are subunits of the linear ubiquitin chain assembly complex. Their function and specific molecular mechanisms in hepatocellular carcinoma (HCC) have not been reported previously.
Xijun Chen, Qing Ye, Wenxiu Zhao, Xiaoqin Chi, Chengrong Xie, Xiaomin Wang   +5 more
doaj   +1 more source

β-Lapachone Selectively Kills Hepatocellular Carcinoma Cells by Targeting NQO1 to Induce Extensive DNA Damage and PARP1 Hyperactivation

Frontiers in Oncology, 2021
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death globally. Currently there is a lack of tumor-selective and efficacious therapies for hepatocellular carcinoma. β-Lapachone (ARQ761 in clinical form) selectively kill NADPH:
Wenxiu Zhao, Wenxiu Zhao, Lingxiang Jiang, Ting Fang, Fei Fang, Yingchun Liu, Ye Zhao, Yuting You, Hao Zhou, Xiaolin Su, Jiangwei Wang, Sheng Liu, Yaomin Chen, Jun Wan, Jun Wan, Xiumei Huang   +15 more
doaj   +1 more source

Long Noncoding RNA HCAL Facilitates the Growth and Metastasis of Hepatocellular Carcinoma by Acting as a ceRNA of LAPTM4B

Molecular Therapy: Nucleic Acids, 2017
Long noncoding RNAs (lncRNAs) are a new class of regulatory noncoding RNAs. Emerging evidences indicate that lncRNAs play a critical role in the development of hepatocellular carcinoma (HCC).
Cheng-Rong Xie, Fei Wang, Sheng Zhang, Fu-Qiang Wang, Sen Zheng, Zhao Li, Jie Lv, He-Qiang Qi, Qin-Liang Fang, Xiao-Min Wang, Zhen-Yu Yin   +10 more
doaj   +1 more source

Hepatocellular carcinoma

Journal of British Surgery, 1998
Abstract Background Hepatocellular carcinoma is one of the world's most common malignancies. The aims of the present paper are to review data on (1) epidemiology and screening programmes for the early detection of the tumour and (2) advances in the diagnostic imaging and management.
Akriviadis, E. A., Llovet, J. M., Efremidis, S. C., Shouval, D., Canelo, R., Ringe, B., Meyers, W. C.   +6 more
openaire   +5 more sources

Molecular pathogenesis and systemic therapies for hepatocellular carcinoma

Nature Cancer, 2022
Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers. The poor outcome associated with HCC is dramatically changing due to the advent of effective systemic therapies.
J. Llovet, R. Pinyol, R. Kelley, A. El-Khoueiry, H. Reeves, X. Wang, G. Gores, A. Villanueva   +7 more
semanticscholar   +1 more source

Fibrolamellar hepatocellular carcinoma treated with atezolizumab and bevacizumab: two case reports

Journal of Medical Case Reports, 2021
Background Fibrolamellar hepatocellular carcinoma is a unique tumor of the liver that differs from the classical hepatocellular carcinoma in diagnosis, behavior, and possibly treatment.
Ali AL Zahrani, Ali Alfakeeh
doaj   +1 more source

Risk prediction for dermatomyositis-associated hepatocellular carcinoma

BMC Bioinformatics, 2023
Objective To explore dermatomyositis signature genes as potential biomarkers of hepatocellular carcinoma and their associated molecular regulatory mechanisms.
Xusheng Zhang, Yongxin Ma, Kejun Liu, Long Chen, Lin Ding, Weihu Ma, Bendong Chen   +6 more
doaj   +1 more source

Emerging Therapies for Hepatocellular Carcinoma (HCC)

Cancers, 2022
Simple Summary Primary liver cancer, also known as Hepatocellular carcinoma (HCC), is considered to be a major global health challenge. Due to delays in diagnosis at early asymptomatic stages, HCC reaches a severe aggressive stage, thereby having a ...
Eesha Chakraborty, D. Sarkar
semanticscholar   +1 more source

Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases

Clinical Liver Disease, 2019
and Scope This guidance provides a data-supported approach to the diagnosis, staging, and treatment of patients diagnosed with hepatocellular carcinoma (HCC). A guidance document is different from a guideline.
J. Marrero, L. Kulik, C. Sirlin, A. Zhu, R. Finn, M. Abecassis, L. Roberts, J. Heimbach   +7 more
semanticscholar   +1 more source

ZNF561 antisense RNA 1 contributes to angiogenesis in hepatocellular carcinoma through upregulation of platelet-derived growth Factor-D

Chinese Journal of Physiology, 2022
Hepatocellular carcinoma is a common malignant tumor with high recurrence rate. Long non-coding RNA (lncRNA) ZNF561 antisense RNA 1 (ZNF561-AS1) functions as an oncogenic lncRNA to promote the tumorigenesis of colorectal cancer. The role of ZNF561-AS1 in
Jihu Zheng, Zijian Guo, Zhanchao Wen, Huikang Chen   +3 more
doaj   +1 more source