Results 61 to 70 of about 2,051,186 (321)

A single-cell atlas of the multicellular ecosystem of primary and metastatic hepatocellular carcinoma

Nature Communications, 2022
Hepatocellular carcinoma (HCC) represents a paradigm of the relation between tumor microenvironment (TME) and tumor development. Here, we generate a single-cell atlas of the multicellular ecosystem of HCC from four tissue sites. We show the enrichment of
Yiming Lu, Aiqing Yang, Cheng Quan, Yingwei Pan, Haoyun Zhang, Yuanfeng Li, Chengming Gao, Hao Lu, Xueting Wang, Pengbo Cao, Hongxia Chen, Shi-xin Lu, Gangqiao Zhou   +12 more
semanticscholar   +1 more source

Spatially resolved visualization of reprogrammed metabolism in hepatocellular carcinoma by mass spectrometry imaging

Cancer Cell International, 2023
Background Metabolic reprogramming refers to tumor-associated metabolic alterations during tumorigenesis and has been regarded as one of the most important features of cancer.
Bangzhen Ma, Yang Zhang, Jiwei Ma, Xinguo Chen, Chenglong Sun, Chengkun Qin   +5 more
doaj   +1 more source

Impact of remnant vital tissue after locoregional treatment and liver transplant in hepatocellular cancer patients. A multicentre cohort study [PDF]

, 2018
The role of pathological findings after locoregional treatments as predictors of hepatocellular cancer recurrence after liver transplantation has been poorly addressed.
Angelico, Mario, Angelico, Roberta, Carvalheiro, Amanda, Iesari, Samuele, Komuta, Mina, Lai, Quirino, Lerut, Jan, Manzia, Tommaso M., Montalti, Roberto, Nicolini, Daniele, Orlacchio, Antonio, Palmieri, Giampiero, Perera, M. Thamara P. R., Quaranta, Claudia, Scarpelli, Marina, Shah, Tahir, Tisone, Giuseppe, Vivarelli, Marco   +17 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

miR-100 Suppresses the Proliferation, Invasion, and Migration of Hepatocellular Carcinoma Cells via Targeting CXCR7

Journal of Immunology Research, 2021
This study is to elucidate the functions of miR-100 in hepatocellular carcinoma progression and to explore the underlying mechanisms. Expression levels of miR-100 in normal-cancer hepatocellular carcinoma tissues were measured using quantitative real ...
Yiman Ge, Jia Shu, Gang Shi, Fuguo Yan, Yejing Li, Hangliang Ding   +5 more
doaj   +1 more source

Radioembolization in the setting of liver transplantation. Great expectations or hard times? [PDF]

, 2018
Trans-arterial radio-embolization (TARE) with yttrium-90 represents one of the most efficacious approaches for the treatment of selected patients with advanced hepatocellular cancer (HCC) (1).
Lai, Quirino, Mennini, Gianluca
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

METTL21A promotes hepatocellular carcinoma progression via methylating and stabilizing BAG3

npj Precision Oncology
Protein methyltransferases regulate diverse physiological and pathological processes through histone and non-histone substrate methylation. While the role of histone methyltransferases in tumorigenesis is well-established, the contribution of non-histone
Ping Zhan, Yizhe Cheng, Yingcan Wu, Jing Lu, Jing Wen, Xiaoqin Chi, Changhong Luo, Yiwei Peng, Xijun Chen, Fuqiang Wang, Zhenyu Yin, Chengrong Xie   +11 more
doaj   +1 more source

Hepatocellular carcinoma and multidrug resistance: Past, present and new challenges for therapy improvement [PDF]

, 2015
Hepatocellular carcinoma (HCC) is the most common malignancy of the liver and the third cause of cancer death worldwide. Chronic hepatitis due to HBV and HCV infection are two major risk factors for HCC worldwide.
Cuestas, María Luján, Mathet, Veronica Lidia, Oubiña, Jose Raul   +2 more
core   +1 more source

Molecular pathogenesis and systemic therapies for hepatocellular carcinoma

Nature Cancer, 2022
Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers. The poor outcome associated with HCC is dramatically changing due to the advent of effective systemic therapies.
J. Llovet, Roser Pinyol, R. Kelley, A. El-Khoueiry, H. Reeves, X. Wang, G. Gores, A. Villanueva   +7 more
semanticscholar   +1 more source