Results 131 to 140 of about 950,403 (244)

Further Insights Into the Mechanisms of Lymph Node Metastasis

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Metastasis of malignant tumors arising from epithelial organs to sentinel lymph nodes has important implications for prognosis, staging, and therapeutic decision‐making. Recent insights into anatomic pathways, pathogenesis, molecular interactions, and genetic factors have encouraged scientists and clinicians to develop drugs that target ...
S. David Nathanson, Meghan J. O'Melia, Kelly C. Rosso, Ian S. Wood, Drishti Lall, Jenny T. Bui   +5 more
wiley   +1 more source

Real-World Outcomes of Tyrosine Kinase Inhibitor–Based Therapy in Advanced Thyroid Carcinoma: A Single-Center Retrospective Study

Cerrahpaşa Medical Journal
Objective: Advanced thyroid carcinoma includes biologically distinct subtypes with variable clinical behavior, and the outcomes of targeted therapy in routine practice may differ from those reported in clinical trials.
Seda Jeral Evinç, Zeliha Birsin, Selin Cebeci, Ebru Çiçek, Süheyla Atak, Süleyman Sami Güzel, Nebi Serkan Demirci, Özkan Alan   +7 more
doaj   +1 more source

Genomic Alterations in Pulmonary Carcinoid Tumors: A Targeted Analysis of Gene Rearrangements and Oncogenic Mutations

Cancer Medicine, Volume 15, Issue 11, November 2026.
This study applied RNA‐based next‐generation sequencing to one of the largest cohorts of pulmonary carcinoid tumors analyzed to date and revealed rare yet potentially actionable gene rearrangements and variants, including alterations in ALK, BRAF, and EGFR.
Jenni Niinimäki, Soili Kytölä, Ari Ristimäki, Johanna Arola, Tiina Vesterinen   +4 more
wiley   +1 more source

[Medullary carcinoma of the thyroid. A report of 4 clinical cases and a review of the literature]

, 1997
Medullary thyroid carcinoma is an uncommon neoplasia among other differentiated carcinomas or the thyroid gland. We have retrospectively analysed four new cases of medullary thyroid carcinoma and a careful review or the literature on the subject has been
Arturi, A, Spina, C, Barone Adesi, T L, Russo, F, Gentileschi, P, Rulli, F, Forlini, A   +6 more
core   +1 more source

Potential Association of BRCA Mutation and Lymphocytic Lobulitis

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Lymphocytic lobulitis (LL) is a rare fibroinflammatory breast lesion historically associated with long‐standing Type 1 diabetes mellitus and autoimmune conditions. Recent evidence suggests possible links between LL and hereditary breast cancer syndromes, particularly BRCA mutations. We present the case of a BRCA1 mutation carrier who developed
Parul Garg, Sena Park, Femi E. Ayeni, Senarath Edirimanne   +3 more
wiley   +1 more source

Preoperative cytologic diagnosis of medullary carcinoma of the thyroid [La diagnosi citologica preoperatoria nel carcinoma midollare della tiroide.]

, 1989
Preoperative cytologic diagnosis of medullary carcinoma of the thyroid [La diagnosi citologica preoperatoria nel carcinoma midollare della tiroide.
Russo, Fadda G, Capelli, Rabitti, Coronetta, F., R.M., Minimo, C., A.   +9 more
core  

Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability

, 2016
Introduction: Colorectal medullary carcinoma (MC) is a rare subtype of poorly differentiated adenocarcinoma (PDA) with unclear prognostic significance.
Alejandro Padilla-Rosciano, Erika B. Ruiz-García, Ángel Herrera-Gómez, Miguel A. Gómez-Álvarez, Leonardo S. Lino-Silva, Rosa A. Salcedo-Hernández, José M. Aguilar-Romero, Horacio N. López-Basave, German Calderillo-Ruiz, Jorge A. Domínguez-Rodríguez, Abelardo Meneses-García   +10 more
core   +1 more source

Regulatory T Cells in Health and Disease

MedComm, Volume 7, Issue 11, November 2026.
Regulatory T cells (Tregs) arise through distinct developmental pathways and adapt to specialized tissue niches to maintain immune tolerance, barrier integrity, and metabolic homeostasis. In disease, Tregs undergo context‐dependent changes, ranging from functional insufficiency and lineage instability in autoimmune, inflammatory, cardiovascular, and ...
Mingyi Li, Si Zhang, Tangchun Wu, Tingting Tang, Xiang Cheng   +4 more
wiley   +1 more source

SURMOUNT‐REAL UK: A Pragmatic Randomized Clinical Trial to Assess the Effectiveness of Tirzepatide in Adults With Obesity

Obesity, Volume 34, Issue 11, Page 2051-2060, November 2026.
ABSTRACT Objective SURMOUNT‐REAL UK will evaluate the effectiveness of tirzepatide when offered in addition to standard‐of‐care (SoC) in adults with Class I obesity (BMI ≥ 30 and ≤ 34.9 kg/m2) and without diabetes in a UK primary care setting. Methods A 5‐year, phase 4, multicenter, open‐label, pragmatic randomized clinical trial is enabled through ...
Martin K. Rutter, Julie Mount, J. Martin Gibson, Joanne Webb, Cheryl Marler, Catherine Reed, Mugdha Gore, Wenyu Ye, Elisa Gomez Valderas, John Wilding, Naveed Sattar, Melanie J. Davies, Kamlesh Khunti, Richard Haynes, Rachel L. Batterham   +14 more
wiley   +1 more source

Medullary-like hepatocellular carcinoma

, 2018
Hepatocellular carcinoma (HCC) is the most frequent primary hepatic cancer. Pathological features can define the biological behavior and prognosis. Medullary-like HCC is a very rare variant that has been described only twice in literature. In the present
Laura Rubbia Brandt, Ruben Carlo Balzarotti Canger, Jessica Barizzi, Mario Alerci, Marco Varini, Majno, Pietro, Cristaudi, Alessandra, Rubbia-Brandt, Laura, Raffaele Rosso, Pietro Majno, Alessandra Cristaudi, Balzarotti Canger, Ruben Carlo, Barizzi, Jessica, Rosso, Raffaele, Alerci, Mario, Varini, Marco, Barizzi J, Majno P, Rubbia Brandt L, Varini M, Alerci M, Balzarotti Canger RC, Cristaudi A, Rosso R   +23 more
core   +1 more source