Diagnostic Utility of TTF-1 and P40 Immunohistochemical Markers for Subtyping of Non-Small Cell Lung Carcinoma [PDF]
Background : Lung cancer is the leading cause of cancer-related mortality over worldwide. Although the pathological diagnosis of lung carcinoma is limited as only small specimen available for diagnosis, the availability of targeted therapies has created ...
Anjana Arya+4 more
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Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer [PDF]
Background Squamous cell lung carcinomas account for approximately 25% of new lung carcinoma cases and 40,000 deaths per year in the United States. Although there are multiple genomically targeted therapies for lung adenocarcinoma, none has yet been ...
A Bardelli+74 more
core +6 more sources
Non-small cell lung carcinoma in an adolescent manifested by acute paraplegia due to spinal metastases: a case report [PDF]
Introduction Bronchial carcinomas in childhood and adolescence are extremely rare; only individual cases have been reported previously. Case presentation We report on a 16-year-old Caucasian German boy with non-small cell lung carcinoma (squamous cell ...
AA Adjei+17 more
core +5 more sources
Life Threatening haemoptysis in primary lung cancer-signet ring cell carcinoma [PDF]
© 2020 The Author(s) Primary signet ring cell carcinoma of the lung is a rare non-small cell carcinoma of the lung with extremely aggressive features and poor prognosis.
Acharya, S.+4 more
core +4 more sources
The Comparative Pathology of Genetically Engineered Mouse Models for Neuroendocrine Carcinomas of the Lung [PDF]
Introduction: Because small-cell lung carcinomas (SCLC) are seldom resected, human materials for study are limited. Thus, genetically engineered mouse models (GEMMs) for SCLC and other high-grade lung neuroendocrine (NE) carcinomas are crucial for ...
Berns, Anton+11 more
core +3 more sources
A Case of Bowen’s Disease and Small-Cell Lung Carcinoma: Long-Term Consequences of Chronic Arsenic Exposure in Chinese Traditional Medicine [PDF]
Chronic arsenic toxicity occurs primarily through inadvertent ingestion of contaminated water and food or occupational exposure, but it can also occur through medicinal ingestion.
Castren K+8 more
core +2 more sources
Partial Response in an RRx-001-Primed Patient with Refractory Small-Cell Lung Cancer after a Third Introduction of Platinum Doublets. [PDF]
Small-cell lung cancer (SCLC), initially exquisitely sensitive to first-line cisplatin/etoposide, invariably relapses and acquires a multidrug chemoresistant phenotype that generally renders retreatment with first-line therapy both futile and ...
Brzezniak, Christina+7 more
core +3 more sources
Resection of multifocal non–small cell lung cancer when the bronchioloalveolar subtype is involved [PDF]
ObjectiveBronchioloalveolar lung cancer is commonly multifocal and can also present with other non–small cell types. The staging and treatment of multifocal non–small cell cancer are controversial.
Benfield, John R+6 more
core +1 more source
Overexpression of the non-coding SOX2OT variants 4 and 7 in lung tumors suggests an oncogenic role in lung cancer [PDF]
Despite the advances in cancer therapy, lung cancer still remains the most leading cause of cancer death worldwide. The long non-coding RNAs (lncRNAs) are recently introduced as novel regulators of human cancers. SOX2 overlapping transcript (SOX2OT) is a
Ghanei, M.+4 more
core +1 more source
TTF-1/p63-positive poorly differentiated NSCLC: A histogenetic hypothesis from the basal reserve cell of the terminal respiratory unit [PDF]
TTF-1 is expressed in the alveolar epithelium and in the basal cells of distal terminal bronchioles. It is considered the most sensitive and specific marker to define the adenocarcinoma arising from the terminal respiratory unit (TRU). TTF-1, CK7, CK5/6,
Barraco N.+8 more
core +1 more source