Results 21 to 30 of about 825,494 (348)

Partial Response in an RRx-001-Primed Patient with Refractory Small-Cell Lung Cancer after a Third Introduction of Platinum Doublets. [PDF]

, 2016
Small-cell lung cancer (SCLC), initially exquisitely sensitive to first-line cisplatin/etoposide, invariably relapses and acquires a multidrug chemoresistant phenotype that generally renders retreatment with first-line therapy both futile and ...
Brzezniak, Christina, Cabrales, Pedro, Caroen, Scott, Carter, Corey A, Degesys, Aiste, Oronsky, Bryan, Reid, Tony R, Scicinski, Jan   +7 more
core   +3 more sources

Influence of ABO blood group on susceptibility to different pathological types of lung cancer: a retrospective study

World Journal of Surgical Oncology, 2022
Purpose Current research has shown a link between ABO blood group and many diseases. The purpose of this study aimed to investigate the influence of the ABO blood group on the risk of developing different pathological types of lung cancer.
Haotian Yang, Xianjun Zeng, Yu Zhang, Weilai Tong, Geliang Yao, Chunyu Lan, Jiaming Liu, Zhili Liu, Nanshan Zhong   +8 more
doaj   +1 more source

Five-Year Survival and Correlates Among Patients With Advanced Melanoma, Renal Cell Carcinoma, or Non–Small Cell Lung Cancer Treated With Nivolumab

JAMA Oncology, 2019
This secondary analysis of the phase 1 CA209-003 clinical trial assesses the 5-year survival and other related factors among patients with advanced melanoma, renal cell carcinoma, or non–small cell lung cancer receiving nivolumab.
S. Topalian, F. Hodi, J. Brahmer, S. Gettinger, David C. Smith, D. McDermott, J. Powderly, J. Sosman, J. Sosman, M. Atkins, M. Atkins, P. Leming, D. Spigel, S. Antonia, A. Drilon, J. Wolchok, R. Carvajal, R. Carvajal, M. McHenry, F. Hosein, C. Harbison, J. Grosso, M. Sznol   +22 more
semanticscholar   +1 more source

Spatial Density and Distribution of Tumor-Associated Macrophages Predict Survival in Non–Small Cell Lung Carcinoma

Cancer Research, 2020
This study underlines the significance of the density, spatial distribution, and gene expression of TAM phenotypes as prognostic factors for overall survival in lung cancer.
Xiang Zheng, A. Weigert, S. Reu, S. Guenther, S. Mansouri, B. Bassaly, S. Gattenlöhner, F. Grimminger, Soni Savai Pullamsetti, W. Seeger, H. Winter, R. Savai   +11 more
semanticscholar   +1 more source

KRAS‐G12D mutation drives immune suppression and the primary resistance of anti‐PD‐1/PD‐L1 immunotherapy in non‐small cell lung cancer

Cancer Communications, 2022
Although immune checkpoint inhibitors (ICIs) against programmed cell death protein 1 (PD‐1) and its ligand PD‐L1 have demonstrated potency towards treating patients with non‐small cell lung carcinoma (NSCLC), the potential association between Kirsten rat
Chengming Liu, Sufei Zheng, Zhanyu Wang, Sihui Wang, Xinfeng Wang, Lu Yang, Haiyan Xu, Z. Cao, Xiaoli Feng, Q. Xue, Yan Wang, N. Sun, Jie He   +12 more
semanticscholar   +1 more source

The Comparative Pathology of Genetically Engineered Mouse Models for Neuroendocrine Carcinomas of the Lung [PDF]

, 2018
Introduction: Because small-cell lung carcinomas (SCLC) are seldom resected, human materials for study are limited. Thus, genetically engineered mouse models (GEMMs) for SCLC and other high-grade lung neuroendocrine (NE) carcinomas are crucial for ...
Berns, Anton, Brambilla, Elisabeth, Farago, Anna F., Gazdar, Adi F., Jacks, Tyler E., Johnson, Jane E., Linnoila, R. Ilona, MacPherson, David, McFadden, David Glenn, Sage, Julien, Savage, Trisha K., Travis, William D.   +11 more
core   +1 more source

N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer

Molecular Cancer, 2021
Background An in-depth understanding of immune evasion mechanisms in tumors is crucial to overcome resistance and enable innovative advances in immunotherapy. Circular RNAs (circRNAs) have been implicated in cancer progression.
Zhenchuan Liu, Tingting Wang, Y. She, Kaiqin Wu, Shaorui Gu, Lei Li, C. Dong, Chang Chen, Yongxin Zhou   +8 more
semanticscholar   +1 more source

Long noncoding nature brain-derived neurotrophic factor antisense is associated with poor prognosis and functional regulation in non–small cell lung caner

Tumor Biology, 2017
In this study, we evaluated the prognostic potential and functional regulation of human nature antisense, brain-derived neurotrophic factor antisense, in non–small cell lung cancer.
MingJing Shen, Zhonghua Xu, Kanqiu Jiang, Weihua Xu, Yongbin Chen, ZhongHeng Xu   +5 more
doaj   +1 more source

Durable response to durvalumab‐based immunochemotherapy in small‐cell lung carcinoma transformation from EGFR‐mutant non–small cell lung cancer: A case report

Thoracic Cancer, 2022
Combined small‐cell lung carcinoma (C‐SCLC) is small‐cell lung carcinoma (SCLC) with added non–small‐cell morphology. We report a case of epidermal growth factor receptor (EGFR) mutation‐positive C‐SCLC in an 84‐year‐old patient with metastatic brain ...
Yu‐Chung Li
doaj   +1 more source

Overexpression of the non-coding SOX2OT variants 4 and 7 in lung tumors suggests an oncogenic role in lung cancer [PDF]

, 2016
Despite the advances in cancer therapy, lung cancer still remains the most leading cause of cancer death worldwide. The long non-coding RNAs (lncRNAs) are recently introduced as novel regulators of human cancers. SOX2 overlapping transcript (SOX2OT) is a
Ghanei, M., Mowla, S.J., Saghaeian Jazi, M., Samaei, N.M., Shadmehr, M.B.   +4 more
core   +1 more source