Results 31 to 40 of about 689,752 (349)

Five-Year Survival and Correlates Among Patients With Advanced Melanoma, Renal Cell Carcinoma, or Non–Small Cell Lung Cancer Treated With Nivolumab

JAMA Oncology, 2019
This secondary analysis of the phase 1 CA209-003 clinical trial assesses the 5-year survival and other related factors among patients with advanced melanoma, renal cell carcinoma, or non–small cell lung cancer receiving nivolumab.
S. Topalian, F. Hodi, J. Brahmer, S. Gettinger, David C. Smith, D. McDermott, J. Powderly, J. Sosman, J. Sosman, M. Atkins, M. Atkins, P. Leming, D. Spigel, S. Antonia, A. Drilon, J. Wolchok, R. Carvajal, R. Carvajal, M. McHenry, F. Hosein, C. Harbison, J. Grosso, M. Sznol   +22 more
semanticscholar   +1 more source

N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer

Molecular Cancer, 2021
Background An in-depth understanding of immune evasion mechanisms in tumors is crucial to overcome resistance and enable innovative advances in immunotherapy. Circular RNAs (circRNAs) have been implicated in cancer progression.
Zhenchuan Liu, Tingting Wang, Y. She, Kaiqin Wu, Shaorui Gu, Lei Li, C. Dong, Chang Chen, Yongxin Zhou   +8 more
semanticscholar   +1 more source

Influence of ABO blood group on susceptibility to different pathological types of lung cancer: a retrospective study

World Journal of Surgical Oncology, 2022
Purpose Current research has shown a link between ABO blood group and many diseases. The purpose of this study aimed to investigate the influence of the ABO blood group on the risk of developing different pathological types of lung cancer.
Haotian Yang, Xianjun Zeng, Yu Zhang, Weilai Tong, Geliang Yao, Chunyu Lan, Jiaming Liu, Zhili Liu, Nanshan Zhong   +8 more
doaj   +1 more source

Vascular invasion in non-small cell lung carcinoma. [PDF]

Journal of Clinical Pathology, 1992
To determine if there is any correlation between vascular invasion and prognosis in non-small cell carcinoma of the lung; and to look specifically at invasion of vascular channels by tumour cells.Eighty seven patients undergoing lobectomy or pneumonectomy for adenocarcinoma or squamous carcinoma were followed up for five years.
R. A. M. Lawson, Philip S. Hasleton, C Musgrove, T. E. Roberts, Ric Swindell   +4 more
openaire   +3 more sources

Long noncoding nature brain-derived neurotrophic factor antisense is associated with poor prognosis and functional regulation in non–small cell lung caner

Tumor Biology, 2017
In this study, we evaluated the prognostic potential and functional regulation of human nature antisense, brain-derived neurotrophic factor antisense, in non–small cell lung cancer.
MingJing Shen, Zhonghua Xu, Kanqiu Jiang, Weihua Xu, Yongbin Chen, ZhongHeng Xu   +5 more
doaj   +1 more source

Durable response to durvalumab‐based immunochemotherapy in small‐cell lung carcinoma transformation from EGFR‐mutant non–small cell lung cancer: A case report

Thoracic Cancer, 2022
Combined small‐cell lung carcinoma (C‐SCLC) is small‐cell lung carcinoma (SCLC) with added non–small‐cell morphology. We report a case of epidermal growth factor receptor (EGFR) mutation‐positive C‐SCLC in an 84‐year‐old patient with metastatic brain ...
Yu‐Chung Li
doaj   +1 more source

Tumor-derived exosomal miR-3157-3p promotes angiogenesis, vascular permeability and metastasis by targeting TIMP/KLF2 in non-small cell lung cancer

Cell Death and Disease, 2021
Metastasis is the main cause of death in patients with advanced lung cancer. The exosomes released by cancer cells create tumor microenvironment, and then accelerate tumor metastasis.
Zijian Ma, Ke Wei, Fengming Yang, Zizhang Guo, Chunfeng Pan, Yaozhou He, Jun Wang, Zhihua Li, Liang Chen, Yijiang Chen, Yang Xia   +10 more
semanticscholar   +1 more source

Immune-Related Gene Expression Profiling After PD-1 Blockade in Non-Small Cell Lung Carcinoma, Head and Neck Squamous Cell Carcinoma, and Melanoma.

Cancer Research, 2017
Antibody targeting of the immune checkpoint receptor PD1 produces therapeutic activity in a variety of solid tumors, but most patients exhibit partial or complete resistance to treatment for reasons that are unclear.
A. Prat, A. Navarro, L. Paré, N. Reguart, P. Galván, T. Pascual, Alex Martínez, P. Nuciforo, L. Comerma, L. Alós, N. Pardo, S. Cedres, C. Fan, J. Parker, L. Gaba, I. Victoria, N. Viñolas, A. Vivancos, A. Arance, E. Felip   +19 more
semanticscholar   +1 more source

Radiosensitization of non-small cell lung carcinoma by EGFR inhibition [PDF]

Nuclear Technology and Radiation Protection, 2014
Molecular targeted cancer therapy is a promising treatment strategy. Considering the central role of the epidermal growth factor receptor in cell proliferation and survival, there are indications that targeted agents like tyrosine kinase inhibitors, i. e., erlotinib, may enhance the antitumor treatment by radiation. The aim of this study is
Otilija Keta, Tanja Bulat, Lela Koricanac, Jelena Zakula, Giacomo Cuttone, Giuseppe Privitera, Ivan Petrovic, Aleksandra Ristic-Fira   +7 more
openaire   +4 more sources

The crosstalk between p38 and Akt signaling pathways orchestrates EMT by regulating SATB2 expression in NSCLC cells

Tumor Biology, 2017
Epithelial–mesenchymal transition is a crucial event for metastasis and could be mediated by several pathways such as phosphoinositide 3-kinase/Akt, mitogen-activated protein kinases, as well as many epigenetic regulators.
Hakan Kucuksayan, Hakan Akca
doaj   +1 more source