Results 81 to 90 of about 689,752 (349)

Clinical potential of necitumumab in non-small cell lung carcinoma

OncoTargets and Therapy, 2016
Despite significant progress, new therapeutic approaches for advanced non-small cell lung cancer (NSCLC) are highly needed, particularly for the treatment of patients with squamous cell carcinoma. The epidermal growth factor receptor (EGFR) is often overexpressed in NSCLC and represents a relevant target for specific treatments. Although EGFR mutations
Genova C., Hirsch F. R.
openaire   +5 more sources

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Classification of Histopathology Images of Lung Cancer Using Convolutional Neural Network (CNN) [PDF]

arXiv, 2021
Cancer is the uncontrollable cell division of abnormal cells inside the human body, which can spread to other body organs. It is one of the non-communicable diseases (NCDs) and NCDs accounts for 71% of total deaths worldwide whereas lung cancer is the second most diagnosed cancer after female breast cancer.
arxiv  

New and old biomarkers in the differential diagnosis of lung cancer: Pro-gastrin-releasing peptide in comparison with neuron-specific enolase, carcinoembryonic antigen, and CYFRA 21-1. [PDF]

, 2019
Background: Testing for circulating biomarkers in lung cancer is hampered by the insufficient specificity. We aimed to assess the relative diagnostic accuracy of pro-gastrin-releasing peptide (ProGRP) for the differential diagnosis of small cell lung ...
Cristian Mauro, Davide Radice, Domenico Galetta, Lorenzo Spaggiari, M. Teresa Sandri, Paola Lentati, Rita Passerini   +6 more
core   +1 more source

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Surgically resected sarcomatoid carcinoma of the lung: a nationwide retrospective study in 2010

BMC Cancer
Background Sarcomatoid carcinoma of the lung is a rare histological type of non-small cell lung cancer with a poor prognosis. We aimed to investigate the clinicopathological characteristics and prognostic factors of surgically resected sarcomatoid ...
Kaoru Kaseda, Keisuke Asakura, Yasushi Shintani, Jiro Okami, Shinichi Toyooka, Yukio Sato, Shun-Ichi Watanabe, Masayuki Chida, Hidemi Suzuki, Etsuo Miyaoka, Ichiro Yoshino, Hiroshi Date, The Japanese Joint Committee of Lung Cancer Registry   +12 more
doaj   +1 more source

Pulmonary pleomorphic carcinoma presenting as undifferentiated non-small cell carcinoma with giant cells: A case report and review of literature

Respiratory Medicine Case Reports, 2020
Pulmonary pleomorphic carcinoma (PPC) is a poorly differentiated non-small cell lung carcinoma, including squamous cell carcinoma, adenocarcinoma, or undifferentiated non-small cell lung carcinoma with at least 10% spindle and/or giant cells.
Jae-Han Jeong, Hong-Joo Seo, Sung-Ho Yoon, Ran Hong   +3 more
doaj  

Convolution Neural Networks for diagnosing colon and lung cancer histopathological images [PDF]

arXiv, 2020
Lung and Colon cancer are one of the leading causes of mortality and morbidity in adults. Histopathological diagnosis is one of the key components to discern cancer type. The aim of the present research is to propose a computer aided diagnosis system for diagnosing squamous cell carcinomas and adenocarcinomas of lung as well as adenocarcinomas of colon
arxiv  

Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small-cell lung cancer

Annals of Oncology, 2018
Background The composition of gut microbiota affects antitumor immune responses, preclinical and clinical outcome following immune checkpoint inhibitors (ICI) in cancer.
L. Derosa, L. Derosa, M. Hellmann, M. Hellmann, M. Spaziano, D. Halpenny, Marine Fidelle, Marine Fidelle, H. Rizvi, N. Long, A. Plodkowski, K. Arbour, J. Chaft, J. Chaft, J. Rouche, L. Zitvogel, G. Zalcman, L. Albiges, B. Escudier, B. Routy   +19 more
semanticscholar   +1 more source

Deep Learning for the Classification of Small-Cell and Non-Small-Cell Lung Cancer

Cancers, 2020
Reliable entity subtyping is paramount for therapy stratification in lung cancer. Morphological evaluation remains the basis for entity subtyping and directs the application of additional methods such as immunohistochemistry (IHC).
M. Kriegsmann, Christian Haag, Cleo-Aron Weis, Georg Steinbuss, A. Warth, C. Zgorzelski, T. Muley, H. Winter, M. Eichhorn, F. Eichhorn, J. Kriegsmann, P. Christopolous, Michael Thomas, M. Witzens‐Harig, P. Sinn, M. Winterfeld, C. Heussel, F. Herth, F. Klauschen, A. Stenzinger, K. Kriegsmann   +20 more
semanticscholar   +1 more source