Results 151 to 160 of about 213,511 (352)

Metabolic Regulation of Epithelial to Mesenchymal Transition: Implications for Endocrine Cancer [PDF]

, 2019
York University ...
Bhattacharya, Debasmita, Scimè, Anthony
core   +1 more source

A Novel method for IDC Prediction in Breast Cancer Histopathology images using Deep Residual Neural Networks [PDF]

arXiv, 2019
Invasive ductal carcinoma (IDC), which is also sometimes known as the infiltrating ductal carcinoma, is the most regular form of breast cancer. It accounts for about 80% of all breast cancers. According to the American Cancer Society, more than 180,000 women in the United States are diagnosed with invasive breast cancer each year.
arxiv  

CCN1 Enhances Tumor Immunosuppression through Collagen‐Mediated Chemokine Secretion in Pancreatic Cancer

Advanced Science, EarlyView.
CCN1 modulates the tumor microenvironment in pancreatic cancer by promoting collagen‐dependent chemokine production, thereby facilitating immune evasion. Deletion of CCN1 not only suppresses tumor growth but also enhances immune cell infiltration and increases tumor sensitivity to both chemotherapy and immunotherapy.
Hongjie Fan, Huzi Zhao, Lili Gao, Yucheng Dong, Pei Zhang, Pengfei Yu, Yunfei Ji, Zhe‐Sheng Chen, Xinmiao Liang, Yang Chen   +9 more
wiley   +1 more source

Pseudotumor pancreático

Revista do Colégio Brasileiro de Cirurgiões
The decrease in morbidity and mortality of pancreaticoduodenectomy in reference centers has increased the incidence of benign histopathologic diagnosis in cases where a pre-operative diagnosis of pancreatic ductal carcinoma was expected (9,2%).
Augusto Paulino Netto
doaj   +1 more source

Is there a place for surgery in oligometastatic ductal carcinoma of the pancreatic head?

Almanac of Clinical Medicine
Background: New chemotherapy regimens (gemcitabine / nab-paclitaxel, FOLFIRINOX) have improved overall survival rates in ductal carcinoma, which has renewed the interest in surgical treatment for isolated liver metastases. Aim: To identify the role of surgery in ductal carcinoma of the pancreatic head with liver oligometastases.
Vasiliy I. Egorov, Aleksey G. Kotelnikov, Yury I. Patyutko, Danil V. Podluzhny, Alexandr N. Polyakov, Nikolai E. Kudashkin, Albert N. Daminov   +6 more
openaire   +2 more sources

CXCL6 Reshapes Lipid Metabolism and Induces Neutrophil Extracellular Trap Formation in Cholangiocarcinoma Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
CXCL6's function in cholangiocarcinoma is underexplored. Here it is discovered that CXCL6 is upregulated in cholangiocarcinoma tissues and promotes proliferation and metastasis of it. CXCL6 functions through the CXCR1/2‐JAK‐STAT/PI3K axis and reshaping tumor lipid metabolism.
Tian He, Zi‐Yi Wang, Bin Xu, Cheng‐Jie Zhong, Lu‐Na Wang, Huan‐Chen Shi, Zi‐Yue Yang, Shi‐Qi Zhou, Hui Li, Bo Hu, Xiao‐Dong Zhu, Ying‐Hao Shen, Jian Zhou, Jia Fan, Hui‐Chuan Sun, Cheng Huang   +15 more
wiley   +1 more source

Exploiting inflammation for therapeutic gain in pancreatic cancer [PDF]

, 2013
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy associated with <5% 5-year survival, in which standard chemotherapeutics have limited benefit.
A Fukuda, A Li, A Neesse, A Ochi, A Ochi, A Sica, A Vincent, A Yamasaki, AB Lowenfels, AD Rhim, AF Hezel, B Farrow, BF El-Rayes, C Guerra, C J McKay, C R Carter, C W Steele, CE Clark, D Melisi, DA Tuveson, DD Von Hoff, DI Gabrilovich, E Rozenblum, FR Balkwill, G Kloppel, GL Beatty, GM DeNicola, H Funahashi, H Ijichi, J P Morton, JA Rivera, Jea Ling, JH Egberts, JP Neoptolemos, JR Infante, KE Lee, KK Frese, KP Olive, KT Liby, LJ Bayne, M Lesina, MA Jacobetz, N B Jamieson, N Hiraoka, O J Sansom, OJ Finn, PP Provenzano, RB Corcoran, RH Hruban, RO Dillman, S Acharyya, S Baumgart, S Chakraborty, S Koido, S Kusmartsev, SF Sener, T Hagemann, T R J Evans, XL Tan, Y Pylayeva-Gupta, ZG Fridlender   +60 more
core   +1 more source

CNN-based Survival Model for Pancreatic Ductal Adenocarcinoma in Medical Imaging [PDF]

arXiv, 2019
Cox proportional hazard model (CPH) is commonly used in clinical research for survival analysis. In quantitative medical imaging (radiomics) studies, CPH plays an important role in feature reduction and modeling. However, the underlying linear assumption of CPH model limits the prognostic performance.
arxiv  

C1q+ Macrophage–Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
In the TME of NPC, C1q secreted by C1q+ TAMs interacted with GPR17 to activate PI3K/AKT signaling through strengthening GPR17 coupling PI3K and increasing calcium levels in tumor cells. The activated PI3K/AKT signaling further induces DNA hypermethylation to promote the malignancy and stemness of tumor cells.
Yunzhi Liu, Cuicui Huang, Min Luo, Wenfu Lu, Baifeng Zhang, Lu Bai, Shuyue Zheng, Yanan Tan, Shanshan Li, Huali Wang, Lanqi Gong, Xinyuan Guan   +11 more
wiley   +1 more source

Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells

BMC Cancer, 2019
Background Despite its relatively low incidence, pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer deaths because of the aggressive growth/metastasis of the tumor, the lack of early symptoms, and the poor treatment options.
Jesse Bakke, William C. Wright, Anthony E. Zamora, Peter Oladimeji, Jeremy Chase Crawford, Christopher T. Brewer, Robert J. Autry, William E. Evans, Paul G. Thomas, Taosheng Chen   +9 more
doaj   +1 more source