Results 161 to 170 of about 213,511 (352)

Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential. [PDF]

, 2015
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. The aggressiveness and therapeutic recalcitrance of this malignancy has been attributed to multiple factors including the influence of an active desmoplastic stroma.
Balaji, Uthra, Freinkman, Elizaveta, Knudsen, Erik S., McCue, Peter, Witkiewicz, Agnieszka K.   +4 more
core   +2 more sources

Precision‐Guided Stealth Missiles in Biomedicine: Biological Carrier‐Mediated Nanomedicine Hitchhiking Strategy

Advanced Science, EarlyView.
Diagram illustrating the binding methods of NPs and biological barriers. The biological carrier‐mediated nanomedicine hitchhiking strategy (BCM‐NHS) utilizes two distinct techniques: the surface‐based “Backpack” method, which relies on ligand‐receptor binding, covalent conjugation, and non‐covalent binding, and the encapsulated “Trojan horse” approach,
Yuyan Zhou, Xinyue Wang, Deyu Zhang, Hanxiao Cui, Xiaorong Tian, Wei Du, Zhenghui Yang, Dongling Wan, Zhiwei Qiu, Chao Liu, Zhicheng Yang, Lizhihong Zhang, Qiusheng Yang, Xuefeng Xu, Wenhao Li, Dong Wang, Haojie Huang, Wencheng Wu   +17 more
wiley   +1 more source

How grim is pancreatic cancer?

Oncology Reviews, 2016
Pancreatic ductal carcinoma continues to be the most lethal malignancy with rising incidence. It is the fourth most common cause of cancer death in the western world due to its low treatment success rate.
Elroy Patrick Weledji, George Enoworock, Martin Mokake, Motaze Sinju   +3 more
doaj   +1 more source

Regulation of pancreatic cancer aggressiveness by stromal stiffening [PDF]

, 2016
No abstract ...
A Neesse, AD Rhim, BC Özdemir, H Laklai, I Barbieri, JJ Lee, JK Mouw, JM Bailey, Michael F Olson, Nicola Rath, P Bailey, SR Hingorani, SR Hingorani, V Sanz-Moreno   +13 more
core   +1 more source

Role of circulating exosomal biomarkers and their diagnostic accuracy in pancreatic cancer

JGH Open, Volume 7, Issue 1, Page 30-39, January 2023., 2023
This systematic review aims to evaluate the current literature involving pancreatic cancer patient groups in search of highly accurate exosomal biomarkers. We reviewed 9 studies which involved 565 participants (331 PC and 234 controls). The mRNA panel (ARG1, CD63, CK18, Erbb3, GAPDH, H3F3A, KRAS, and ODC1) and GPC1 reported the highest performing ...
Menazir Sha, Basir Kunduzi, Saied Froghi, Alberto Quaglia, Brian Davidson, Giuseppe K Fusai   +5 more
wiley   +1 more source

Multi-Cancer Computational Analysis Reveals Metastasis-Associated Variant of Desmoplastic Reaction Involving INHBA and THBS2 [PDF]

, 2010
Despite extensive research, the details of the metastasis-associated biological mechanisms are largely unknown. Here, we analyze data from multiple cancers using a novel computational method identifying sets of genes whose coordinated overexpression ...
Dimitris Anastassiou, Hoon Kim, John Watkinson, Vinay Varadan   +3 more
core   +1 more source

Absence of an embryonic stem cell DNA methylation signature in human cancer. [PDF]

, 2019
BackgroundDifferentiated cells that arise from stem cells in early development contain DNA methylation features that provide a memory trace of their fetal cell origin (FCO). The FCO signature was developed to estimate the proportion of cells in a mixture
Christensen, Brock C, Kelsey, Karl T, Koestler, Devin C, Salas, Lucas A, Wiencke, John K, Zhang, Ze   +5 more
core  

Updated risk prediction model for pancreaticoduodenectomy using data from the National Clinical Database in Japan

Annals of Gastroenterological Surgery, EarlyView.
The calibration plots of the updated risk models for the endpoints were analyzed in each cohort. The predicted probability of each endpoint matched the observed probability in the development and validation cohorts. Abstract Aim Risk prediction models for mortality, severe postoperative complications, and postoperative pancreatic fistula in patients ...
Masamichi Mizuma, Hideki Endo, Hiroyuki Yamamoto, Mitsuhiro Shimura, Masahiro Iseki, Michiaki Unno, Taro Oshikiri, Yoshihiro Kakeji, Ken Shirabe   +8 more
wiley   +1 more source

Combined effect of frailty and sarcopenia on postoperative complications in older adults undergoing curative surgery for hepato‐biliary‐pancreatic cancer

Annals of Gastroenterological Surgery, EarlyView.
A multivariable logistic regression model was performed using covariates that were significant in the bivariable analyses, including bile duct cancer, longer operative times, and greater blood loss. Prefrail or frail status combined with sarcopenia remained significant in this model (OR 4.74; 95% CI, 1.10–20.29; p = 0.04).
Norifumi Harimoto, Keishi Sugimachi, Tomohiro F. Nishijima, Tomino Takahiro, Tomonari Shimagaki, Yohei Mano, Emi Onishi, Masahiko Sugiyama, Yasue Kimura, Masaru Morita   +9 more
wiley   +1 more source

Survival benefit of adjuvant therapy completion with early initiation for patients with pancreatic ductal adenocarcinoma

Annals of Gastroenterological Surgery, EarlyView.
Adjuvant completion with early initiation may contribute to the improved survival of patients with pancreatic ductal adenocarcinoma. Abstract Aim To evaluate the prognostic effect of initiation timing and completion of adjuvant therapy in patients with pancreatic ductal adenocarcinoma.
Kenjiro Okada, Kenichiro Uemura, Tatsuaki Sumiyoshi, Ryuta Shintakuya, Kenta Baba, Takumi Harada, Yasutaka Ishii, Shiro Oka, Yoshiaki Murakami, Shinya Takahashi   +9 more
wiley   +1 more source