Results 171 to 180 of about 89,882 (308)

Spatial Location of SPP1+TAMs and Mutually Exclusive Subsets Based on Single‐Cell and Transcriptome Data

Cancer Science, EarlyView.
This study indicates that SPP1, as an important regulator of tumor progression, is upregulated in various tumors and has been associated with a poor prognosis. SPP1+M2 has a unique spatial location at the forefront of tumor invasion and metastasis, thereby promoting tumor progression. MARCO+M2, which forms a mutually exclusive relationship with SPP1+M2,
Xuan Luo, JianGuo Xu, ZhiYuan Wang, XiaoFang Wang, YangHao Wang, Yu Zhang, FangFang Li, Hui Fang, XiaoYun Huang, MuYe Li, XiaoJuan Liu, JiHong Tang, PeiYang Fan, GuoJing Zhao, YongWen He, Li Bian   +15 more
wiley   +1 more source

An Unexpected Manifestation of Non-islet Cell Tumor Hypoglycemia in Pancreatic Ductal Adenocarcinoma. [PDF]

Cureus
Alomar T, Kaur J, Horani M, Alomar S, Syoufi I.   +4 more
europepmc   +1 more source

Carbonic Anhydrase 12 as a Novel Prognostic Biomarker and Therapeutic Target for High‐Risk Follicular Thyroid Carcinoma

Cancer Science, EarlyView.
In this study, we identified a novel biomarker, carbonic anhydrase 12 (CA12), to better distinguish high‐risk follicular thyroid carcinoma (FTC). High CA12 expression is associated with poor prognosis and CA12 promotes tumor cell growth and invasion. This study suggests that CA12 is not only an independent predictor of disease‐free survival but also a ...
Masashi Tanida, Tsuyoshi Takashima, Shinichiro Tahara, Masaharu Kohara, Haruka Kanai, Masami Suzuki, Motoyuki Suzuki, Mitsuyoshi Hirokawa, Ayana Suzuki, Shinya Sato, Daisuke Okuzaki, Satoshi Nojima, Takahiro Matsui, Hidenori Inohara, Eiichi Morii   +14 more
wiley   +1 more source

A Transcriptomic Analysis of Cancer‐Stromal Interactome in Lung Cancer Xenograft Models

Cancer Science, EarlyView.
We conducted a comprehensive analysis of the lung cancer interactome to identify key ligand–receptor pairs involved in the aggressiveness of lung adenocarcinoma. Tumor necrosis factor superfamily member 12 and its receptor tumor necrosis factor receptor superfamily member 12A signaling axis may be potential candidates for therapeutic intervention for ...
Yuriko Takayama‐Isagawa, Daisuke Komura, Takayuki Isagawa, Yusuke Amano, Atsushi Kihara, Tamaki Miura, Taichiro Yoshimoto, Hiroyoshi Tsubochi, Kazutaka Fujita, Koichi Hagiwara, Makoto Maemondo, Tetsuo Ushiku, Shumpei Ishikawa, Noriyoshi Fukushima, Kentaro Inamura, Daisuke Matsubara, Toshiro Niki   +16 more
wiley   +1 more source

Prognostic value of miR-21 in colorectal cancer, pancreatic ductal adenocarcinoma, and esophageal squamous cell carcinoma: updated systematic review and meta-analysis. [PDF]

Oncologist
Huang J, He Q, Wang J, Zhai C.
europepmc   +1 more source

A YAP/TAZ–CDC6 Axis Initiates and Maintains Malignant Transformation

Cancer Science, EarlyView.
This study demonstrates that constitutive activation of YAP or TAZ is sufficient to induce and maintain malignant transformation in fibroblasts, identifying them as essential oncogenic drivers. Transcriptomic and functional analyses revealed CDC6 as a critical downstream effector of YAP/TAZ, with elevated expression linked to tumorigenesis across ...
David Nduru, Yudai Ohta, Akihiro Nita, Mayumi Niimura, Samson Ngurari, Toshiro Moroishi   +5 more
wiley   +1 more source

A Cystic Variant of Acinar Cell Carcinoma of the Pancreas with Repeated Bleeding from a Pseudoaneurysm: A Case Report. [PDF]

Surg Case Rep
Morishima K, Endo K, Sasanuma H, Sakuma Y, Fukushima N, Yamaguchi H, Sata N.   +6 more
europepmc   +1 more source

Single‐Cell and Multiomic Analysis Reveals Neutrophil Heterogeneity and Prognostic Value in Cervical Lesions

Cancer Science, EarlyView.
This study is the first to identify a novel neutrophil subpopulation, N4, that is closely associated with the progression of cervical cancer. Characterized by high PLAU expression and specific interactions with tumor cells, N4 neutrophils were shown to promote tumor growth and immune modulation.
Ze Wang, Liang Zhuang, Shiyi Liu, Canhui Cao, Shimin Chen, Nan Yu, Xiaoyuan Huang, Tao Zhang   +7 more
wiley   +1 more source

A long non-coding RNA SCAMP1 induces pancreatic ductal adenocarcinoma progression through miR-106a-5p/AGK signaling. [PDF]

Clin Exp Med
Du X, Cai Y, Kuang P, Zeng M, Huang Y, Huang S.   +5 more
europepmc   +1 more source

LCN2‐ACOD1 Signalling Affects the Post‐Injury Regeneration of Skeletal Muscle Through Mediating Ferroptosis

Cell Proliferation, EarlyView.
LCN2 mediates the suppression of C2C12 myoblast proliferation and myotube formation via erastin‐induced ferroptosis. Mechanistically, the LCN2‐ACOD1 axis regulates skeletal muscle growth via mitochondria‐associated ferroptosis, providing a theoretical basis for the prevention and therapy of muscle‐related diseases.
Xiaojing Hao, Hongwei Shi, Di Wu, Rui Liang, Tong Zhao, Wen Sun, Yue Wang, Xiuju Yu, Xiaomao Luo, Yi Yan, Jiayin Lu, Haidong Wang, Juan Wang   +12 more
wiley   +1 more source