Results 51 to 60 of about 213,511 (352)

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular-fibrosis and tumor progression

Nature Network Boston, 2016
Fibrosis compromises pancreatic ductal carcinoma (PDAC) treatment and contributes to patient mortality, yet antistromal therapies are controversial. We found that human PDACs with impaired epithelial transforming growth factor-β (TGF-β) signaling have ...
Hanane Laklai, Y. Miroshnikova, Michael W. Pickup, E. Collisson, Grace E. Kim, Alexander S Barrett, Ryan C. Hill, J. Lakins, D. Schlaepfer, J. Mouw, Valerie S. LeBleu, Nilotpal Roy, S. Novitskiy, J. Johansen, V. Poli, R. Kalluri, C. Iacobuzio-Donahue, L. Wood, M. Hebrok, K. Hansen, H. Moses, V. Weaver   +21 more
semanticscholar   +1 more source

Role of Fibroblast Growth Factor Receptor 2 in Pancreatic Cancer: Potential Target for New Therapeutic Approach? [PDF]

, 2015
Fibroblast growth factors and their receptors play a key role in cell proliferation, migration and differentiation. Fibroblast growth factor receptor 2 (FGFR2) is involved in carcinogenesis and its altered expression has been shown in several tumors ...
Angeloni, Antonio, Ceccarelli, Simona, Vescarelli, Enrica   +2 more
core   +1 more source

Gluing GAP to RAS Mutants: A New Approach to an Old Problem in Cancer Drug Development [PDF]

arXiv, 2023
Mutated genes may lead to cancer development in numerous tissues. While more than 600 cancer-causing genes are known today, some of the most widespread mutations are connected to the RAS gene: RAS mutations are found in approximately 25% of all human tumors.
arxiv  

A case of pancreatic ductal adenocarcinoma with marked infiltration with IgG4-positive cells

Journal of Cytology, 2013
A 75-year-old man was diagnosed as having pancreatic ductal carcinoma containing remarkable lymphocytic and plasma cell infiltration, as revealed by the cytological examination of endoscopic ultrasound guided fine-needle aspiration (EUS-FNA) specimen ...
M Yoneda, H Inada, K Kanayama, T Shiraishi   +3 more
doaj   +1 more source

Pictorial Review of Rare Pancreatic Tumors and Tumor-Like Lesions

대한영상의학회지, 2020
Various types of tumors and tumor-like lesions may affect the pancreas. Among them, pancreatic ductal adenocarcinoma is the most common and is generally referred to as “pancreatic cancer.” Recently, the detection rates of rare pancreatic tumors and ...
Seung Jae Lee, Sang Soo Shin, Suk Hee Heo, Yong Yeon Jeong   +3 more
doaj   +1 more source

Activity of Mesothelin-Specific Chimeric Antigen Receptor T Cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial.

Gastroenterology, 2018
Pancreatic ductal adenocarcinoma (PDAC) is resistant to T-cell-mediated immunotherapy. We engineered T cells to transiently express a messenger RNA encoding a chimeric antigen receptor (CAR) specific for mesothelin, a protein that is overexpressed by ...
G. Beatty, M. O'Hara, S. Lacey, D. Torigian, Farzana Nazimuddin, Fang Chen, I. Kulikovskaya, M. Soulen, M. McGarvey, A. Nelson, W. Gladney, B. Levine, J. Melenhorst, G. Plesa, C. June   +14 more
semanticscholar   +1 more source

Anaplastic carcinoma of the pancreas diagnosed by endoscopic ultrasound-guided fine-needle aspiration: a case report and review of the literature

Journal of Medical Case Reports, 2018
Background Anaplastic carcinoma of the pancreas is a rare pancreatic neoplasm with a poor prognosis. It is classified as a variant of ductal adenocarcinoma, but the clinical features and treatment of it remain unknown because of its rarity and ...
Kohei Oka, Ken Inoue, Satoshi Sugino, Taishi Harada, Toshifumi Tsuji, Shingo Nakashima, Takayuki Katayama, Takashi Okuda, Syuichi Kin, Akihiro Nagata, Toshiyuki Komaki, Keizo Kagawa   +11 more
doaj   +1 more source

IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival [PDF]

, 2014
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant desmoplastic reaction driven by pancreatic stellate cells (PSCs) that contributes to tumor progression.
Al-Assar, Osama, Brunner, Thomas B., Carter, Ross C., Carvalho-Gaspar, Manuela, D'Ugo, Stefano, Griffiths, Kristin L., Jamieson, Nigel B., Janssen, Klaus-Peter, Lim, Su Yin, Lunardi, Serena, McKay, Colin J., Muschel, Ruth J., Sansom, Owen J., Silva, Michael A., Spoletini, Gabriele, Yameen, Sabira   +15 more
core   +2 more sources

The role of radiotherapy in multimodal treatment of pancreatic carcinoma

Radiation Oncology, 2010
Pancreatic ductal carcinoma is one of the most lethal malignancies, but in recent years a number of positive developments have occurred in the management of pancreatic carcinoma.
Scott-Brown Martin, Brunner Thomas B
doaj   +1 more source

MicroRNA co-expression networks exhibit increased complexity in pancreatic ductal compared to Vater’s papilla adenocarcinoma [PDF]

, 2017
iRNA expression abnormalities in adenocarcinoma arising from pancreatic ductal system (PDAC) and Vater’s papilla (PVAC) could be associated with distinctive pathologic features and clinical cancer behaviours.
Andriulli, Angelo, Biagini, Tommaso, Capocefalo, Daniele, Carella, Massimo, Copetti, Massimiliano, De Bonis, Antonio, Di Sebastiano, Pierluigi, Francesco Di Mola, Fabio, Fusilli, Caterina, Maiello, Evaristo, Mastrodonato, Nicola, Mazza, Tommaso, Pazienza, Valerio, Piepoli, Ada, Tavano, Francesca   +14 more
core   +1 more source