Results 211 to 220 of about 2,870,098 (295)

Occult Thyroid Carcinoma Localized to Three Cervical Lymph Nodes Without Primary Origin in the Thyroid Gland: A Case Report. [PDF]

Case Rep Endocrinol
Murayama D, Nishida Y, Hishikawa S, Hirano R, Hashizume T, Azuhata K, Shimojo H, Ito N, Mishima O.   +8 more
europepmc   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

Predicting Macrophage Spatial Localization from Single‐Cell Transcriptomes to Uncover Disease Mechanisms

Advanced Science, EarlyView.
This study presents a machine‐learning framework entitled MERLIN that infers the microanatomical localization of macrophages from single‐cell transcriptomic data in structured organs such as the kidney and brain. Applying this method to existing datasets from models of acute kidney injury and diabetic nephropathy uncovered spatially resolved insights ...
Junping Yin, Qi Mei, Hans‐Joachim Paust, Ning Song, Yu Zhao, Daniela Klaus, Melanie Eichler, Yijun Hua, Jie Qin, Weiting Cheng, Christina K. Weisheit, Veronika Lukacs‐Kornek, Isis Ludwig‐Portugall, Sibylle von Vietinghoff, Christian F. Krebs, Johanna Klughammer, Ulf Panzer, Christian Kurts, Jian Li   +18 more
wiley   +1 more source

An AI Approach to Differentiating Lung Squamous Cell Carcinoma From Metastases of Other Origins.

JAMA Netw Open
Evans MG, Ribeiro JR, Maney T, Helmstetter A, Johnson J, Karnezis AN, Bales C, Sledge GW, Spetzler D, Vanderwalde A, Oberley M, Halmos B, Borghaei H, Abdulla F, Bryant D, Hirsch FR, Ghani H.   +16 more
europepmc   +1 more source

High Efficacy of Chemoimmunotherapy in Advanced ALK-Rearranged Lung Squamous Cell Carcinoma: A Case Report. [PDF]

Cancer Manag Res
Niu Y, Ding B, Shi J, Yang Y, Zhao J, Wang D.   +5 more
europepmc   +1 more source

TRIM47 Regulates Energy Metabolism via Glycolytic Reprogramming to Drive Hepatocellular Carcinoma Progression and Represents an Efficient Therapeutic Target

Advanced Science, EarlyView.
This study identifies TRIM47 as a key driver of liver cancer progression by promoting glycolysis through ubiquitin‐mediated degradation of the gluconeogenic enzyme FBP1. TRIM47 enhances glucose uptake, lactate and ATP production, and tumor growth and metastasis.
Weijie Sun, Yihang Yuan, Qian Qiu, Kexuan Tan, Xutong Li, Haotian Li, Luyang Kang, Yuting Gu, Ziheng Zhang, Jiayu He, Jiali Li, Junjie Lin, Zihan Xie, Kexing Han, Jiabin Li, Yang Zhang, Ting Wu, Yufeng Gao   +17 more
wiley   +1 more source

RETRACTED: Wang et al. HSP70-eIF4G Interaction Promotes Protein Synthesis and Cell Proliferation in Hepatocellular Carcinoma. <i>Cancers</i> 2020, <i>12</i>, 3410. [PDF]

Cancers (Basel)
Wang M, Wei K, Qian B, Feiler S, Lemekhova A, Büchler MW, Hoffmann K.   +6 more
europepmc   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source