Results 41 to 50 of about 3,245,969 (343)

Sunitinib versus interferon alfa in metastatic renal-cell carcinoma.

New England Journal of Medicine, 2007
BACKGROUND Since sunitinib malate has shown activity in two uncontrolled studies in patients with metastatic renal-cell carcinoma, a comparison of the drug with interferon alfa in a phase 3 trial is warranted.
R. Motzer, Thomas E. Hutson, P. Tomczak, M. Michaelson, R. Bukowski, O. Rixe, S. Oudard, S. Négrier, C. Szczylik, Sindy T. Kim, I. Chen, P. Bycott, C. Baum, R. Figlin   +13 more
semanticscholar   +1 more source

Epidemiology of Hepatocellular Carcinoma

Hepatology, 2020
Liver cancer is a major contributor to the worldwide cancer burden. Incidence rates of this disease have increased in many countries in recent decades.
K. McGlynn, J. Petrick, H. El‐Serag
semanticscholar   +1 more source

Identifying high-risk candidates for prolonging progression-free survival in primary gastric carcinoma subject to “double invasion”: an analytical approach utilizing lasso-cox regression

BMC Cancer
Objective To identify high-risk gastric carcinoma patients with concurrent vascular and neural invasion (“double invasion”) who are at heightened risk of progression-free survival (PFS) decline, enabling personalized clinical management.
Liwei Wang, Yu Chang, Jinfeng Ma, Wenqing Qu, Yifan Li   +4 more
doaj   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Harnessing Machine Learning and Nomogram Models to Aid in Predicting Progression-Free Survival for Gastric Cancer Patients Post-Gastrectomy with Deficient Mismatch Repair(dMMR)

BMC Cancer
Objective To assess the effectiveness of a machine learning framework and nomogram in predicting progression-free survival (PFS) post-radical gastrectomy in patients with dMMR.
Yifan Li, JinFeng Ma, Wenhua Cheng
doaj   +1 more source

The Transcription Factor Creb is Involved in Sorafenib-Inhibited Renal Cancer Cell Proliferation, Migration and Invasion

Acta Pharmaceutica, 2018
Our previous reports showed that the cyclic-AMP-response element-binding protein (CREB) served as a proto-oncogene in the process of tumorigenesis and mediated the growth and metastatic activity of renal cancer cells.
Huang Shuaishuai, Cui Pinger, Lin Shuangxia, Yao Xuping, Wang Xue, Ren Yu, Weng Guobin   +6 more
doaj   +1 more source

TRIM21 inhibits irradiation-induced mitochondrial DNA release and impairs antitumour immunity in nasopharyngeal carcinoma tumour models

Nature Communications, 2023
The molecular mechanisms determining the response to radiotherapy remain incompletely understood. Here, the authors demonstrate that the E3 ubiquitin ligase and intracellular Fc receptor, TRIM21, impairs CD8+ T cell responses in nasopharyngeal carcinoma ...
Jun-Yan Li, Yin Zhao, Sha Gong, Miao-Miao Wang, Xu Liu, Qing-Mei He, Ying-Qin Li, Sheng-Yan Huang, Han Qiao, Xi-Rong Tan, Ming-Liang Ye, Xun-Hua Zhu, Shi-Wei He, Qian Li, Ye-Lin Liang, Kai-Lin Chen, Sai-Wei Huang, Qing-Jie Li, Jun Ma, Na Liu   +19 more
doaj   +1 more source

Sorafenib in advanced clear-cell renal-cell carcinoma.

New England Journal of Medicine, 2007
BACKGROUND We conducted a phase 3, randomized, double-blind, placebo-controlled trial of sorafenib, a multikinase inhibitor of tumor-cell proliferation and angiogenesis, in patients with advanced clear-cell renal-cell carcinoma.
B. Escudier, T. Eisen, W. Stadler, C. Szczylik, S. Oudard, M. Siebels, S. Négrier, C. Chevreau, E. Solska, A. Desai, F. Rolland, T. Demkow, Thomas E. Hutson, M. Gore, S. Freeman, B. Schwartz, M. Shan, R. Simantov, R. Bukowski   +18 more
semanticscholar   +1 more source

Thyroid Carcinoma, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.

The Journal of the National Comprehensive Cancer Network, 2022
Differentiated thyroid carcinomas is associated with an excellent prognosis. The treatment of choice for differentiated thyroid carcinoma is surgery, followed by radioactive iodine ablation (iodine-131) in select patients and thyroxine therapy in most ...
R. Haddad, Lindsay A. Bischoff, D. Ball, V. Bernet, E. Blomain, N. Busaidy, Michael Campbell, P. Dickson, Q. Duh, H. Ehya, W. Goldner, Theresa W Guo, M. Haymart, Shelby Holt, J. Hunt, A. Iagaru, F. Kandeel, D. Lamonica, S. Mandel, S. Markovina, B. Mciver, C. Raeburn, R. Rezaee, J. Ridge, M. Roth, R. Scheri, J. Shah, J. Sipos, R. Sippel, C. Sturgeon, Thomas Wang, L. Wirth, R. Wong, Michael W Yeh, Carly J Cassara, S. Darlow   +35 more
semanticscholar   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source