Results 111 to 120 of about 220,392 (312)

Combining Spatial Multi‐Omics Data to Decipher Spatial Domains and Elucidate Cell Heterogeneity Based on Self‐Supervised Graph Learning

Advanced Science, EarlyView.
A self‐supervised multi‐view graph fusion framework integrates spatial multi‐omics, excelling in domain identification and denoising. It reconstructs spatial pseudo‐expression, jointly analyzes multi‐omics data, infers RNA velocity, predicts spatial omics features from single‐cell multi‐omics, and detects spatially dark genes and transcription factors,
Yuejing Lu, Rui Qiao, Ying Li, Junhong Li, Nuoya Yue, Jing Ge, Jiao Wang, Luonan Chen, Peiluan Li   +8 more
wiley   +1 more source

Preoperative breast magnetic resonance imaging and contralateral breast cancer occurrence among older women with ductal carcinoma in situ

, 2016
Shi‐Yi Wang, Jessica B. Long, Brigid K. Killelea, Suzanne B. Evans, Kenneth B. Roberts, Andrea Silber, Cary P. Gross   +6 more
openalex   +2 more sources

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Tissue Fixation Conditions for p16 Immunohistochemistry and Human Papillomavirus RNA In Situ Hybridization in Oropharyngeal Squamous Cell Carcinoma

, 2019
James S. Lewis, Shira B. Barnett, Kyle Mannion, Mitra Mehrad   +3 more
openalex   +2 more sources

Invasive Micropapillary Carcinoma in Axillary Ectopic Breast and Synchronous Ductal Carcinoma In Situ in the Contralateral Breast [PDF]

, 2017
Seung Won Oh, Hyo Soon Lim, Ji Shin Lee, Sung Min Moon, Min Ho Park   +4 more
openalex   +1 more source

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

The loss of expression of the tumor suppressor NES1 gene in biopsy-proven ductal carcinoma in situ predicts for invasive carcinoma at definitive surgery [PDF]

, 2002
Michael J. Yunes, D.E. Wazer, Linda Bornstein, Stephen P. Naber, Vimla Band   +4 more
openalex   +1 more source

Data from Analysis of the Transcriptome: Regulation of Cancer Stemness in Breast Ductal Carcinoma <i>In Situ</i> by Vitamin D Compounds

, 2023
Naing Lin Shan, Audrey Minden, Philip Furmanski, Min Ji Bak, Cai Li, Roman Wernyj, Davit Sargsyan, David Cheng, Renyi Wu, Hsiao‐Chen Dina Kuo, Shanyi Li, Mingzhu Fang, Hubert Maehr, Ah‐Ng Tony Kong, Nanjoo Suh   +14 more
openalex   +1 more source

A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression [PDF]

, 2023
Stefan J. Hutten, Roebi de Bruijn, Catrin Lutz, Madelon Badoux, Timo Eijkman, Chao Xue, Marta Ciwinska, Michael Sheinman, Hendrik A. Messal, Andrea Herencia-Ropero, Petra Kristel, Lennart Mulder, Rens van der Waal, Joyce Sanders, Mathilde M. Almekinders, Alba Llop‐Guevara, Helen Davies, Matthijs J. van Haren, Nathaniel I. Martin, Fariba Behbod, Serena Nik‐Zainal, Violeta Serra, Jacco van Rheenen, Esther H. Lips, Lodewyk F.A. Wessels, Jelle Wesseling, Colinda L. G. J. Scheele, Jos Jonkers   +27 more
openalex   +1 more source

Synergistic Probe Combining Lysosome Anchoring and Tumor Defense System Targeting for Precise Tumor Visualization

Advanced Science, EarlyView.
A new generation of high‐precision fluorescent probes based on the lysosomal characteristics in tumor metabolic reprogramming and overexpressed tumor markers. The probe (CN‐D‐GGT) selectively label cancer cells in co‐culture systems and distinguish tumor lesions from inflamedand normal tissues in vivo, enabling precise tumor imaging.
Yang Shen, Jiawei Li, Ruixi Yi, Ling Shi, Wei Li, Sulai Liu, Lin Yuan   +6 more
wiley   +1 more source