Results 91 to 100 of about 217,987 (265)

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

Clinical Risk Factors for Cutaneous Squamous Cell Carcinoma in Patients with Actinic Keratosis or Cutaneous Squamous Cell Carcinoma in Situ: A Retrospective Double-cohort Study

Acta Dermato-Venereologica
Actinic keratosis and cutaneous squamous cell carcinoma in situ are precancerous forms of cutaneous squamous cell carcinoma. In this single-centre retrospective study, patients with histopathologically confirmed actinic keratosis (n = 121) or cutaneous ...
Jaakko S. Knuutila, Olli Kaijala, Salla Lehto, Tero Vahlberg, Liisa Nissinen, Veli-Matti Kähäri, Pilvi Riihilä   +6 more
doaj   +1 more source

Sonogenetic Control of Engineered Probiotics for the Treatment of MASH by Modulating the Gut‐Liver Axis

Advanced Science, EarlyView.
Researchers developed an engineered probiotic encapsulated in an inulin hydrogel, enabling ultrasound‐triggered intestinal delivery of IL‐22. In MASH model mice, this system remodeled gut microbiota, strengthened the intestinal barrier and reduced portal LPS and hepatic IL‐6.
Chunya Ji, Yan Fang, Shen Zhang, Weichen Xu, Wenyun Guo, Jing Chen, Mingrui Zhu, Congjian Wen, Siming Chen, Yuli Zhu, Huixiong Xu, Haohao Yin   +11 more
wiley   +1 more source

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Magnetic Thermal Ablation Combined with Temporally Coordinated CpG Immunotherapy Promotes cDC1‐Dependent Immune Priming in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Novel PLA@Fe3O4 magnetic microspheres were developed for transarterial magnetic hyperthermia ablation (MTA) of hepatocellular carcinoma. While destroying local tumors and inducing immunogenic cell death (ICD), MTA combined with early CpG adjuvant administration significantly promotes cDC1‐dependent immune priming. This synergistic mechanism effectively
Jiakun Yang, Nailin Yang, Shuangshuang Ji, Siping Meng, Di Wang, Wenjun Liang, Xuming Bai, Yong Jin, Xingwei Sun   +8 more
wiley   +1 more source

Complications after medullary thyroid carcinoma surgery: multicentre study of the SQRTPA and EUROCRINE® databases

BJS (British Journal of Surgery), EarlyView., 2020
This study investigated postoperative complications after surgery for medullary thyroid carcinoma (MTC) in Europe. Hypoparathyroidism, recurrent laryngeal nerve palsy and bleeding requiring reoperation occurred in 170 (26·2 per cent), 62 (13·7 per cent) and 17 (2·6 per cent) patients respectively.
D.‐J. van Beek, M. Almquist, A. O. Bergenfelz, T. J. Musholt, E. Nordenström, on behalf of the EUROCRINE® Council, M. Almquist, M. Barczynski, L. Brunaud, T. Clerici, M. H. Hansen, M. Iacobone, Ö. Makay, F. F. Palazzo, N. Muñoz‐Pérez, M. Raffaelli, P. Riss, S. van Slycke, M. R. Vriens   +18 more
wiley   +1 more source

Immunohistochemical profile of high-grade ductal carcinoma in situ of the breast

Clinics, 2013
OBJECTIVE: To determine the frequency of the immunohistochemical profiles of a series of high-grade ductal carcinoma in situ of the breast. METHODS: One hundred and twenty-one cases of high-grade ductal carcinoma in situ, pure or associated with invasive
Amanda Arantes Perez, Rafael Malagoli Rocha, Débora Balabram, Átila da Silva Souza, Helenice Gobbi   +4 more
doaj  

Exploring the interaction mechanisms between cervical carcinoma in situ and antibody-mediated immune responses through Mendelian randomization analysis

Discover Oncology
Objective This study aims to investigate the causal relationship between cervical carcinoma in situ and antibody-mediated immune responses, providing a scientific basis for the prevention and treatment of cervical carcinoma in situ.
Junfei Li, Lihuang He, Qun He, Kaihong Xie, Hui Xie   +4 more
doaj   +1 more source

Multi‐Target Wireless Localization of Miniaturized Magneto–Oscillatory Trackers in Soft Biological Tissues

Advanced Science, EarlyView.
Miniaturized, frequency‐encoded magneto–oscillatory trackers enable wireless localization of multiple targets without prior knowledge of their positions or orientations. The method achieves accurate localization over clinically relevant distances and measures local viscoelasticity via the oscillatory responses.
Liyuan Tan, Jyothi Kumari Mariyanna, Meng Zhang, Alexander Kutscher, Ann‐Sophia Müller, Felix Fischer, Tian Qiu   +6 more
wiley   +1 more source