Results 71 to 80 of about 200,878 (264)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Sebaceous carcinoma in situ as a concept and diagnostic entity

Dermatology Practical & Conceptual, 2017
Although carcinoma in situ has been accepted as a well-established concept and diagnostic category, for reasons unknown sebaceous carcinoma in situ has not been recognized yet in general pathology or dermatopathology.
Miglena K. Komforti, Masoud Asgari, Sheng Chen   +2 more
doaj  

Carcinoma in situ: revisão

Clinical and Biomedical Research, 2022
O carcinoma ductal in situ (CDIS) compreende um grupo de lesões biologicamente e morfologicamente heterogêneo. A sua incidência vem crescendo principalmente devido aos programas de rastreamento por mamografia, o que contribuiu para o aumento do seu ...
Jorge V. Biazús, Fernando Schuh
doaj  

Carcinoma in situ: revisão

Clinical and Biomedical Research, 2017
O carcinoma ductal in situ (CDIS) compreende um grupo de lesões biologicamente e morfologicamente heterogêneo. A sua incidência vem crescendo principalmente devido aos programas de rastreamento por mamografia, o que contribuiu para o aumento do seu diagnóstico entre pacientes assintomáticas. O achado mais freqüente é de microcalcificações.
Biazús, Jorge Villanova, Schuh, Fernando   +1 more
openaire   +2 more sources

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Importance of microcalcifications in mammographic differentiation of the invasive ductal breast cancer and of the ductal carcinoma in situ [PDF]

Medicinski Podmladak, 2017
Introduction: Microcalcifications represent a significant and reliable sign of the presence of the malignant breast lesion. Aim: The aim of the paper is to radiologically evaluate the type and distribution of suspicious microcalcifications, in patients ...
Šarac Vanja, Nadrljanski Mirjan
doaj  

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Evaluation of survivin immunoexpression in the differentiation of high- and low-grade breast ductal carcinoma in situ

Einstein (São Paulo)
Objective To evaluate the expression of survivin protein in low- and high-grade ductal carcinoma in situ. Methods Breast tissue fragments obtained by incisional biopsy and surgical procedures of 37 women with ductal carcinoma in situ of the breast were ...
Milca Cezar Chade, Sebastião Piato, Maria Antonieta Longo Galvão, José Mendes Aldrighi, Rômulo Negrini, Evandro Falaci Mateus, Enio Martins Medeiros   +6 more
doaj   +1 more source

Evaluation of expression of p16INK4a & Survivin in squamous neoplasm of cervix- A 3 years study [PDF]

Perspectives In Medical Research, 2017
Objective: To explore the expression of p16INK4a(p16) & survivin in cervical intraepithelial neoplasm (CIN) & cervical squamous neoplasm. Materials & Methods: A 3years study was undertaken in MGM Hospital, Warangal, all the cervical & hysterectomy ...
S. Lokesh Rao Magar1 , G.Vandana2 , Sobha Devi3 , H.Sandhya Rani4 , Sandhya Anil5
doaj  

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source