Results 51 to 60 of about 3,494 (200)

Pharmacokinetics, Safety, and Efficacy of Intravitreal Digoxin in Preclinical Models for Retinoblastoma [PDF]

, 2015
PURPOSE:To assess in vitro cytotoxic activity and antiangiogenic effect, ocular and systemic disposition, and toxicity of digoxin in rabbits after intravitreal injection as a potential candidate for retinoblastoma treatment.METHODS:A panel of two ...
Abramson, David, Arana, Eloisa, Buitrago, Emiliano, Chantada, Guillermo Luis, Croxatto, Juan Oscar, del Sole, Maria Jose, Djaballah, Hakim, Francis, Jasmine, Laurent, Viviana Eunice, Mena, Hebe Agustina, Negrotto, Soledad, Schaiquevich, Paula Susana, Sgroi, Mariana, Winter, Ursula Andrea   +13 more
core   +2 more sources

Optimizing Growth Conditions for Digoxin Production in Digitalis lanata Ehrh

World Journal of Traditional Chinese Medicine, 2016
Objective: Digoxin is a therapeutic cardenolide widely used to treat various heart conditions such as atrial flutter, atrial fibrillation and heart failure in both Western as well as Chinese medicine. Digoxin is extracted from cultivated Digitalis lanata
Herman A. van Wietmarschen, Hansjörg Hagels, Ron Peters, Jolanda Heistek, Jan van der Greef, Mei Wang   +5 more
doaj   +1 more source

Chemical cues that attract cannibalistic cane toad (Rhinella marina) larvae to vulnerable embryos

Scientific Reports, 2021
Chemical cues produced by late-stage embryos of the cane toad (Rhinella marina) attract older conspecific larvae, which are highly cannibalistic and can consume an entire clutch.
Michael R. Crossland, Angela A. Salim, Robert J. Capon, Richard Shine   +3 more
doaj   +1 more source

Applications of Chitosan, an Eco‐Friendly Biopolymer in Agricultural Systems, Herbal Products, and Functional Foods: A Review

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
Chitosan is highlighted for its industrial applications include food processing and preservation, pharmaceuticals, agriculture systems, and environmental protection. ABSTRACT Chitin, the natural biopolymer of the world next to cellulose, is a modified biodegradable polysaccharide.
Saeedeh Karimlar, Abdollah Ghasemi Pirbalouti, Zahra Teymuori, Maryam Moslehishad, Zohreh Hamidi‐Esfahani   +4 more
wiley   +1 more source

Molecular docking analysis of Carica papaya Linn constituents as antiviral agent [PDF]

, 2017
Carica papaya (papaya) fruits are available throughout the world and it is well accepted as food or as a quasi-drug. Aqueous papaya leaves extract have been used as treatment for dengue fever. This prompted us to carry out the docking study on these nine
Lam, Kok Wai, Mohd Esa, Norhaizan, Narayanaswamy, Radhakrishnan   +2 more
core  

Complex engineering of Solanum alkaloids structural diversity in Nicotiana benthamiana

Plant Biotechnology Journal, Volume 24, Issue 1, Page 328-345, January 2026.
Summary Transient expression in Nicotiana benthamiana offers a powerful and versatile platform for rapid production of complex specialized metabolites. Steroidal glycoalkaloids (SGAs) and steroidal saponins produced by members of the Solanaceae family are known for their diverse structures and activities including antimicrobial, anticancer, antiviral ...
Sachin A. Gharat, Adam Jozwiak, Ilana Rogachev, Elinor A. Sharon, Sagit Meir, Ashok P. Giri, Asaph Aharoni   +6 more
wiley   +1 more source

Evolutionarily stable defence and signalling of that defence [PDF]

, 2006
We examine the evolution and maintenance of defence and conspicuousness in prey species using a game theoretic model. In contrast to previous works, predators can raise as well as lower their attack probabilities as a consequence of encountering ...
Adler, Björkman, Bowers, Bowers, Brodie, Camara, Cohen, Dobler, Endler, G.D. Ruxton, Gamberale-Stille, Grill, Harvey, Irie, Iwasa, Karban, Kearsley, Leimar, M. Broom, M.P. Speed, Mallet, Merilaita, Pearce, Roper, Rowell-Rahier, Ruxton, Servedio, Sherratt, Shudo, Shudo, Shudo, Speed, Speed, Summers, VanDam, Wallace, Yachi, Zalucki   +37 more
core   +2 more sources

Duckweeds: Model organisms for research on plant sterols and steroids

Plant Biology, Volume 28, Issue 1, Page 18-30, January 2026.
Duckweeds (Lemnaceae), the fastest‐growing angiosperms and promising vegan protein source, offer a powerful model to address key questions in plant physiology. This article highlights their potential for dissecting the biosynthesis and function of phytosterols, sterol conjugates, brassinosteroids, and specialized steroidal metabolites, such as ...
J. Klein, K.‐J. Appenroth, K. S. Sree
wiley   +1 more source

Polyphagous insect Olepa sps. feeding on cardenolide rich Calotropis gigantea (L.) leaves and detoxification mechanism involving GST

Heliyon, 2022
Cardenolides, a group of cardiac glycosides are potent inhibitors of Na+/K+ ATPase pump in mammals, animals including insects. Some insects can circumvent the toxicity of cardenolides by mechanisms like target site resistance and metabolic resistance ...
Krishnamanikumar Premachandran, Thanga Suja Srinivasan   +1 more
doaj   +1 more source

Natural Products as Potential Resource Library for Control of Major Swine Enteric Viruses

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Major swine enteric viruses (SEVs), including porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), transmissible gastroenteritis virus (TGEV), swine acute diarrhea syndrome coronavirus (SADS‐CoV), and porcine rotavirus (PoRV), cause severe gastrointestinal diseases in pigs, leading to huge economic losses to the swine industry ...
Jialu Zhang, Yuqian Liu, Shuying Ren, Zhouyuan Wang, Yunxia Li, Lianci Peng, Rendong Fang, Jianchao Wei   +7 more
wiley   +1 more source